Default mode network activity in bipolar disorder

Zovetti, Niccolò; Rossetti, Maria Gloria; Perlini, Cinzia; Maggioni, Eleonora; Bontempi, Pietro; Brambilla, Paolo

doi:10.1017/s2045796020000803

Cited by 60 publications

(32 citation statements)

References 42 publications

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“…As shown in Table 1, resting-state fMRI studies have revealed altered GS topography in several psychiatric and neurological disorders. Similar to abnormal brain regions in classic FC analysis (Kaiser et al, 2015;Li et al, 2018;Syan et al, 2018;Yan et al, 2019;Zovetti et al, 2020), altered GS topography is mainly located in higher-order association networks (such as the DMN, limbic affective network, frontoparietal network, and salience network), with a relatively small part in the sensorimotor network. However, there may be different pathological mechanisms indicated by GS topography and classic FC.…”

Section: Pathological Significance Of the Gs Topographymentioning

confidence: 80%

Global Signal Topography of the Human Brain: A Novel Framework of Functional Connectivity for Psychological and Pathological Investigations

Ouyang

Yang

et al. 2021

Front. Hum. Neurosci.

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The global signal (GS), which was once regarded as a nuisance of functional magnetic resonance imaging, has been proven to convey valuable neural information. This raised the following question: what is a GS represented in local brain regions? In order to answer this question, the GS topography was developed to measure the correlation between global and local signals. It was observed that the GS topography has an intrinsic structure characterized by higher GS correlation in sensory cortices and lower GS correlation in higher-order cortices. The GS topography could be modulated by individual factors, attention-demanding tasks, and conscious states. Furthermore, abnormal GS topography has been uncovered in patients with schizophrenia, major depressive disorder, bipolar disorder, and epilepsy. These findings provide a novel insight into understanding how the GS and local brain signals coactivate to organize information in the human brain under various brain states. Future directions were further discussed, including the local-global confusion embedded in the GS correlation, the integration of spatial information conveyed by the GS, and temporal information recruited by the connection analysis. Overall, a unified psychopathological framework is needed for understanding the GS topography.

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Section: Pathological Significance Of the Gs Topographymentioning

confidence: 80%

Global Signal Topography of the Human Brain: A Novel Framework of Functional Connectivity for Psychological and Pathological Investigations

Ouyang

Yang

et al. 2021

Front. Hum. Neurosci.

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“…The precuneus/PCC and mPFC are major hub nodes of the default-mode network (DMN), which is involved in multiple cognitive and affective functions such as emotional processing, self-referential mental activity, distraction and recollection of experiences, and possibly exerts a modulatory role during attention-requiring tasks (Raichle, 2015). Aberrant activity and connectivity within the DMN are well-documented in different mood states of BD (Syan et al, 2018; Vargas et al, 2013; Wang et al, 2020; Zovetti et al, 2020). For example, previous studies found that hypo-connectivity between the anterior and posterior DMN in manic BD patients might be related to an attention pattern that is excessively focused on external stimuli at the expense of internal reflection (Magioncalda et al, 2015; Wang et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Functional and structural brain differences in bipolar disorder: a multimodal meta-analysis of neuroimaging studies

et al. 2022

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Background Numerous studies of resting-state functional imaging and voxel-based morphometry (VBM) have revealed differences in specific brain regions of patients with bipolar disorder (BD), but the results have been inconsistent. Methods A whole-brain voxel-wise meta-analysis was conducted on resting-state functional imaging and VBM studies that compared differences between patients with BD and healthy controls using Seed-based d Mapping with Permutation of Subject Images software. Results A systematic literature search identified 51 functional imaging studies (1842 BD and 2190 controls) and 83 VBM studies (2790 BD and 3690 controls). Overall, patients with BD displayed increased resting-state functional activity in the left middle frontal gyrus, right inferior frontal gyrus (IFG) extending to the right insula, right superior frontal gyrus and bilateral striatum, as well as decreased resting-state functional activity in the left middle temporal gyrus extending to the left superior temporal gyrus and post-central gyrus, left cerebellum, and bilateral precuneus. The meta-analysis of VBM showed that patients with BD displayed decreased VBM in the right IFG extending to the right insula, temporal pole and superior temporal gyrus, left superior temporal gyrus extending to the left insula, temporal pole, and IFG, anterior cingulate cortex, left superior frontal gyrus (medial prefrontal cortex), left thalamus, and right fusiform gyrus. Conclusions The multimodal meta-analyses suggested that BD showed similar patterns of aberrant brain activity and structure in the insula extending to the temporal cortex, fronto-striatal-thalamic, and default-mode network regions, which provide useful insights for understanding the underlying pathophysiology of BD.

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“…Evidence for affective influences on DMN activity and its interaction with other networks comes from several observations (Buckner and DiNicola, 2019;Kaiser et al, 2015), but their functional significance remains unresolved. A down-regulation of within-DMN connectivity was reported in healthy participants during sad mood induction through self-generated memories (Harrison et al, 2008) or movies (Borchardt et al, 2018), while disturbances of DMN connectivity are observed in clinical mood disorders such as depression and bipolar disease (Rey et al, 2014;Zovetti et al, 2020). Dynamic shifts in the balance between DMN and SN are also thought to mediate adaptive responses to acute stressors, promoting higher vigilance and fear (Zhang et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Dynamic functional brain networks underlying the temporal inertia of negative emotions

Gaviria

Rey

Bolton

et al. 2021

Preprint

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Distributed brain areas are engaged both during and following the elicitation of emotional experiences. Previous studies suggest that transient emotions may cause a prolonged impact (or inertia) on brain states, with corresponding changes in subjective affect and mood. To investigate the functional dynamics and reciprocal interactions among brain networks underlying these effects, we quantified co-activation patterns (CAPs) by recording functional magnetic resonance imaging (fMRI) during sad movies and subsequent resting periods. CAPs overlapping with the visual (VIS), default mode (DMN), central executive (CEN), and frontoparietal control (FPCN) networks showed not only distinctive effects of negative emotion on their spatiotemporal expression in both movie and rest periods, but also different reciprocal relationships among them in transitions from movie to rest. While FPCN and DMN expression increased during and after negative movies, respectively, FPCN occurrences during the movie predicted lower DMN and higher CEN expression during subsequent rest after neutral movies, but this relationship was reversed after negative movies. Changes in FPCN and DMN activity correlated with more negative subjective affect. These findings provide new insights into the functional dynamics and interactions of intrinsic brain networks, highlighting a major role of FPCN in emotion elicitation processes with prolonged impact on DMN activity in subsequent rest, presumably involved in emotion regulation and restoration of homeostatic balance after negative events.

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Default mode network activity in bipolar disorder

Cited by 60 publications

References 42 publications

Global Signal Topography of the Human Brain: A Novel Framework of Functional Connectivity for Psychological and Pathological Investigations

Global Signal Topography of the Human Brain: A Novel Framework of Functional Connectivity for Psychological and Pathological Investigations

Functional and structural brain differences in bipolar disorder: a multimodal meta-analysis of neuroimaging studies

Dynamic functional brain networks underlying the temporal inertia of negative emotions

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