Defect of the Ventricular Septum

Selzer, Arthur

doi:10.1001/archinte.1949.00230050134007

Cited by 95 publications

(6 citation statements)

References 18 publications

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“…This is consistent with other studies where success rate ranged between 87-100% [12][13][14][15][16]. There was no mortality in our study which compares well with the surgical results in which it is between 0-3% [17][18][19][20]. In our study, the total complication rate was 19.5% (most of them minor) with majority of the patients having transient loss of peripheral pulses, hematoma etc.…”

Section: Discussionsupporting

confidence: 92%

Cardiac rhythm abnormalities after transcatheter device closure of perimembraneous ventricular septal defects in pediatric patients at intermediate term follow up

Shah

Thakkar

2016

Int J Pediatr Res

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Background: Transcatheter closure of perimembranous ventricular septal defects in pediatric patients poses special challenges owing to anatomical relationship between conduction system and perimembraneous ventricular septal defect. Aims: The study aims to assess and evaluate the conduction disturbances after transcatheter device closure of perimembranous ventricular septal defect using different occluders at mid-term follow-up. Methods: We studied 297 patients having PMVSD with clinical and/or echocardiographic evidence of a significant left-to-right shunt. All subjects underwent clinical examination, electrocardiogram (ECG), chest X-rays and transthoracic echocardiography before discharge and at 1, 6 and 12-months after the procedure and yearly thereafter. Platelet anti-aggregation therapy with aspirin 5 mg/kg/day orally and endocarditis prophylaxis was prescribed for six months. Results: The mean age of the patients was 8.64±3.14 years (range 3-17.2 years). Majority (86.2%) had no residual shunt at follow-up. Total rhythm disturbances were seen in about 6% (18/297) of patients with transient complete atrioventricular block (CAVB) occurring in 3 patients. There was no mortality in our study which compares well with the surgical results in which it is between 0-3 percent. Conclusions: This study showed that transcatheter closure of PMVSD using symmetric PMVSD occluders and duct occluders is a safe and effective alternative to surgery. Oversizing of devices should be minimized and low profile devices appropriate to specific morphology of VSD should be used. It has excellent results in experienced hands with minimum morbidity and almost no mortality.

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Section: Discussionsupporting

confidence: 92%

Cardiac rhythm abnormalities after transcatheter device closure of perimembraneous ventricular septal defects in pediatric patients at intermediate term follow up

Shah

Thakkar

2016

Int J Pediatr Res

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“…The electrocardiographic diagnosis of right ventricular hypertrophy was based on the criteria established by Sokolow and Lyon (1949), Goodwin (1952), andMilnor (1957). Right ventricular hypertrophy in the presence of right bundle-branch block was diagnosed if the electrocardiogram conformed to the criteria of Wilson et al (1954) and Barker and Valencia (1949).…”

Section: Methodsmentioning

confidence: 99%

“…Originally considered a benign lesion except for the threat of bacterial endocarditis, it is now considered a serious malformation with a relatively poor prognosis (Selzer, 1949;Downing and Goldberg, 1956;Brotmacher and Campbell, 1958) except for small defects with insignificant shunts. The classification of Taussig (1947) into high defects associated with symptoms and low defects with classical signs and few or no symptoms has been challenged (Selzer, 1949). Most defects are located in the membranous septum but the most important factors are the size of the defect and the pulmonary vascular resistance (Selzer, 1949;Wood et al, 1954;Mannheimer et al, 1957).…”

mentioning

confidence: 99%

“…The classification of Taussig (1947) into high defects associated with symptoms and low defects with classical signs and few or no symptoms has been challenged (Selzer, 1949). Most defects are located in the membranous septum but the most important factors are the size of the defect and the pulmonary vascular resistance (Selzer, 1949;Wood et al, 1954;Mannheimer et al, 1957). Thus, the development of pulmonary hypertension with cyanosis, hemoptysis, and death has been reported even with large muscular defects (Heath et al, 1956).…”

mentioning

confidence: 99%

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