SYNOPSIS
A study was undertaken of the relationship of the haemodynamic disturbance of ventricular septal defects to the growth of affected subjects. Stunting was observed, particularly with respect to weight, and occurred mainly but not exclusively in subjects with a large defect. Some subjects already exhibited stunting at birth with evidence of intrauterine growth retardation. By 3 to 12 months of age, the differences in growth between the subjects became marked. There was some improvement subsequently, related in part to improvement in the haemodynamic disturbance.
The pertinent literature is reviewed and the possible mechanisms of the multiple factors involved in the growth retardation are discussed.