Defective barrier function accompanied by structural changes of psoriatic stratum corneum

Takahashi, Hidetoshi; Tsuji, Hitomi; Minami-Hori, Masako; Miyauchi, Yuhei; Iizuka, Hajime

doi:10.1111/1346-8138.12393

Cited by 62 publications

(62 citation statements)

References 23 publications

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“…To test this hypothesis, we evaluated a subset of our subjects for alterations in skin barrier function by transepidermal water loss (TEWL) in response to treatment. We reasoned that if chlorhexidine were to alter the skin, making it more likely to bind free DNA, we should observe an increase in TEWL similar to that seen in patients with atopic dermatitis and other dermatologic conditions (29,30). Upon testing, however, we found no significant differences in TEWL when comparing treatments to each other, or to baseline controls at 1hr and 6hr post-treatment ( Fig.…”

Section: Treatment Depletes Skin Bacterial Community Membership and Rmentioning

confidence: 80%

Antiseptic Agents Elicit Short-Term, Personalized and Body Site-Specific Shifts in Resident Skin Bacterial Communities

SanMiguel

Meisel

Horwinski

et al. 2017

Preprint

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Despite critical functions in cutaneous health and disease, it is unclear how resident skin microbial communities are altered by topical antimicrobial interventions commonly used in personal and clinical settings. Here we show that acute exposure to antiseptic treatments elicits rapid but short-term depletion of microbial community diversity and membership. Thirteen subjects were enrolled in a longitudinal treatment study to analyze the effects of topical treatments (ethanol, povidone-iodine, chlorhexidine, water) on the skin microbiome at two skin sites of disparate microenvironment: forearm and back. Treatment effects were highly dependent on personalized and body site-specific colonization signatures, which concealed community dynamics at the population level when not accounted for in this analysis. The magnitude of disruption was influenced by the identity and abundance of particular bacterial inhabitants. Lowly abundant members of the skin microbiota were more likely to be displaced, and subsequently replaced by the most abundant taxa prior to treatment. Members of the skin commensal family Propionibactericeae were particularly resilient to treatment, suggesting a distinct competitive advantage in the face of disturbance. These results provide insight into the stability and resilience of the skin microbiome, while establishing the impact of topical antiseptic treatment on skin bacterial dynamics and community ecology.peer-reviewed)

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Section: Treatment Depletes Skin Bacterial Community Membership and Rmentioning

confidence: 80%

Antiseptic Agents Elicit Short-Term, Personalized and Body Site-Specific Shifts in Resident Skin Bacterial Communities

SanMiguel

Meisel

Horwinski

et al. 2017

Preprint

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“…Antibiotics can be used to combat inflammatory acne, while retinoids, such as isotretinoin, are effective ‘comedolytics’, which reduce the number of comedones, lower sebum secretion, and cause SG involution (Dahlhoff, Zouboulis & Schneider, ; Kosmadaki & Katsambas, ). Atrophic SGs and altered sebaceous lipid composition have also been observed in patients with psoriasis and atopic dermatitis (Prose, ; Wirth, Gloor & Stoika, ; Burton & Pye, ; Werner, Brenner & Böer, ; Takahashi et al ., ; van Smeden et al ., ; Liakou et al ., ; Rittié et al ., ), suggesting that SG dysfunction may contribute to other inflammatory skin diseases (Shi et al ., ).…”

Section: Relevance Of the Brain–sebaceous Gland Axis To Skin Physiolomentioning

confidence: 99%

Neuroendocrinology and neurobiology of sebaceous glands

et al. 2020

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The nervous system communicates with peripheral tissues through nerve fibres and the systemic release of hypothalamic and pituitary neurohormones. Communication between the nervous system and the largest human organ, skin, has traditionally received little attention. In particular, the neuro-regulation of sebaceous glands (SGs), a major skin appendage, is rarely considered. Yet, it is clear that the SG is under stringent pituitary control, and forms a fascinating, clinically relevant peripheral target organ in which to study the neuroendocrine and neural regulation of epithelia. Sebum, the major secretory product of the SG, is composed of a complex mixture of lipids resulting from the holocrine secretion of specialised epithelial cells (sebocytes). It is indicative of a role of the neuroendocrine system in SG function that excess circulating levels of growth hormone, thyroxine or prolactin result in increased sebum production (seborrhoea). Conversely, growth hormone deficiency, hypothyroidism, and adrenal insufficiency result in reduced sebum production and dry skin. Furthermore, the androgen sensitivity of SGs appears to be under neuroendocrine control, as hypophysectomy (removal of the pituitary) renders SGs largely insensitive to stimulation by testosterone, which is crucial for maintaining SG homeostasis. However, several neurohormones, such as adrenocorticotropic hormone and α-melanocyte-stimulating hormone, can stimulate sebum production independently of either the testes or the adrenal glands, further underscoring the importance of neuroendocrine control in SG biology. Moreover, sebocytes synthesise several neurohormones and express their receptors, suggestive of the presence of neuro-autocrine mechanisms of sebocyte modulation. Aside from the neuroendocrine system, it is conceivable that secretion of neuropeptides and neurotransmitters from cutaneous nerve endings may also act on sebocytes or their progenitors, given that the skin is richly innervated. However, to date, the neural controls of SG development and function remain poorly investigated and incompletely understood. Botulinum toxin-mediated or facial paresis-associated reduction of human sebum secretion suggests that cutaneous nerve-derived substances modulate lipid and inflammatory cytokine synthesis by sebocytes, possibly implicating the nervous system in acne pathogenesis. Additionally, evidence suggests that cutaneous denervation in mice alters the expression of key regulators of SG homeostasis. In this review, we examine the current evidence regarding neuroendocrine and neurobiological regulation of human SG function in physiology and pathology. We further call attention to this line of research as an instructive model for probing and therapeutically manipulating the mechanistic links between the nervous system and mammalian skin.

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“…Alteration of SC lipids composition leads to disrupted or impaired skin barrier functions and results in an increase in transepidermal water loss (TEWL)[11,19]. Increased TEWL has been observed in many skin diseases, such as atopic dermatitis (AD) and psoriasis[20–22]. The major classes of lipids found in the SC include ceramides (CERs), cholesterol (Chol), and free fatty acids (FFAs)[17,23,24].…”

Section: Skin and Epidermal Barriermentioning

confidence: 99%

Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans

Ganguli‐Indra

Indra

2016

Expert Review of Proteomics

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Introduction Lipidomics is the large-scale profiling and characterization of lipid species in a biological system using mass spectrometry. The skin barrier is mainly comprised of corneocytes and a lipid-enriched extracellular matrix. The major skin lipids are ceramides, cholesterol and free fatty acids. Lipid compositions are altered in inflammatory skin disorders with disrupted skin barrier such as atopic dermatitis (AD). Areas covered Here we discuss some of the recent applications of lipidomics in human skin biology and in inflammatory skin diseases such as AD, psoriasis and Netherton syndrome. We also review applications of lipidomics in human skin equivalent and in pre-clinical animal models of skin diseases to gain insight into the pathogenesis of the skin disease. Expert commentary Skin lipidomics analysis could be a fast, reliable and noninvasive tool to characterize the skin lipid profile and to monitor the progression of inflammatory skin diseases such as AD.

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Defective barrier function accompanied by structural changes of psoriatic stratum corneum

Cited by 62 publications

References 23 publications

Antiseptic Agents Elicit Short-Term, Personalized and Body Site-Specific Shifts in Resident Skin Bacterial Communities

Antiseptic Agents Elicit Short-Term, Personalized and Body Site-Specific Shifts in Resident Skin Bacterial Communities

Neuroendocrinology and neurobiology of sebaceous glands

Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans

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