2006
DOI: 10.1016/j.cellimm.2006.09.008
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Defective T cell receptor-mediated signal transduction in memory CD4 T lymphocytes exposed to superantigen or anti-T cell receptor antibodies

Abstract: Lymphocytes must promote protective immune responses while still maintaining self-tolerance. Stimulation through the T cell receptor (TCR) can lead to distinct responses in naive and memory CD4 T cells. Whereas peptide antigen stimulates both naive and memory T cells, soluble anti-CD3 antibodies and bacterial superantigens stimulate only naive T cells to proliferate and secrete cytokines. Further, superantigens, like staphylococcal enterotoxin B (SEB), cause memory T cells to become anergic while soluble anti-… Show more

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Cited by 18 publications
(37 citation statements)
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“…Surprisingly, we found that antigen-activated OT-II Tregs and non-Treg CD4+ T cells did not show detectable early ZAP-70 or PKC-θ phosphorylation, even at very early time points (Supplemental Figures 1 and 2). The finding that superantigen did not signal ZAP-70 activation is consistent with a single published report, which showed that superantigen stimulation did not induce significant ZAP-70 phosphorylation in memory T cells (Watson and Lee, 2006). The discovery that in vitro TCR stimulation by specific antigen does not induce significant early ZAP-70 and PKC-θ activation is novel and suggests that rapid ZAP-70 and PKC-θ activation may be more specific to direct CD3 complex stimulation.…”
Section: Discussionsupporting
confidence: 91%
“…Surprisingly, we found that antigen-activated OT-II Tregs and non-Treg CD4+ T cells did not show detectable early ZAP-70 or PKC-θ phosphorylation, even at very early time points (Supplemental Figures 1 and 2). The finding that superantigen did not signal ZAP-70 activation is consistent with a single published report, which showed that superantigen stimulation did not induce significant ZAP-70 phosphorylation in memory T cells (Watson and Lee, 2006). The discovery that in vitro TCR stimulation by specific antigen does not induce significant early ZAP-70 and PKC-θ activation is novel and suggests that rapid ZAP-70 and PKC-θ activation may be more specific to direct CD3 complex stimulation.…”
Section: Discussionsupporting
confidence: 91%
“…As we have mentioned, SA possesses several virulent, membrane and secreted factors such as protein A and enterotoxins, capable of inducing immune and inflammatory responses with additive or synergic effects [27] . Indeed, the enterotoxins commonly expressed by strains responsible for severe infections in AD [28] have a superantigen activity capable of stimulating a large population of T lymphocytes, with a massive liberation of cytokines involved in the inflammatory process [5,29] . Likewise, the incubation of human epithelial cells from the cornified layer with Staphylococcus protein A leads to nuclear translocation of NF-B and the production of pro-inflammatory cytokines such as tumor necrosis factor-␣ and chemokines such as IL-8, without inducing the expression of antimicrobial peptides (hBD2 and LL-37) [30] .…”
Section: Discussionmentioning
confidence: 99%
“…The low anti-CD3 concentration we used could in part explain our observation because Ahmed et al (45), using the same anti-CD3 dosage, did not demonstrate Zap70 capping. In addition, the immune status of the cells, i.e., Th1 vs Th2 (46) or naive vs memory cells (47), also influences membrane reorganization of signaling complexes.…”
Section: Discussionmentioning
confidence: 99%