Defectos eritrocíticos y densidad de la parasitemia en pacientes con malaria por Plasmodium falciparum en Buenaventura, Colombia

Moyano, Martha; Méndez, Fabián

doi:10.1590/s1020-49892005000600005

Cited by 19 publications

(10 citation statements)

References 22 publications

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“…However, in Ecuador, G6PDd prevalence was higher in provinces that were non-endemic for malaria, compared to endemic provinces, suggesting an ecological association between G6PDd and some degree of protection against P. falciparum [109]. Colombian individuals with a complete G6PD deficiency had a lower density of P. falciparum parasitaemia than persons without this condition [110]. In Colombia, the mean G6PD activity was lower, and G6PDd was more prevalent among men without P. vivax malaria than in those presenting with the disease [111].…”

Section: Resultsmentioning

confidence: 99%

Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

Monteiro

Franca

Queiroz

et al. 2014

Malar J

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BackgroundAlthough G6PDd individuals are generally asymptomatic throughout their life, the clinical burden of this genetic condition includes a range of haematological conditions, including acute haemolytic anaemia (AHA), neonatal jaundice (NNJ) and chronic non-sphaerocytic anaemia (CNSA). In Latin America (LA), the huge knowledge gap regarding G6PDd is related to the scarce understanding of the burden of clinical manifestation underlying G6PDd carriage. The aim of this work was to study the clinical significance of G6PDd in LA and the Caribbean region through a systematic review.MethodsA systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Only original research was included. All study designs were included, as long as any clinical information was present. Studies were eligible for inclusion if they reported clinical information from populations living in LA or Caribbean countries or about migrants from these countries living in countries outside this continent.ResultsThe Medline search generated 487 papers, and the LILACS search identified 140 papers. After applying the inclusion criteria, 100 original papers with any clinical information on G6PDd in LA were retrieved. Additionally, 16 articles were included after reading the references from these papers. These 116 articles reported data from 18 LA and Caribbean countries. The major clinical manifestations reported from LA countries were those related to AHA, namely drug-induced haemolysis. Most of the published works regarding drug-induced haemolysis in LA referred to haemolytic crises in P. vivax malaria patients during the course of the treatment with primaquine (PQ). Favism, infection-induced haemolysis, NNJ and CNSA appear to play only a minor public health role in this continent.ConclusionHaemolysis in patients using PQ seems to be the major clinical manifestation of G6PDd in LA and contributes to the morbidity of P. vivax infection in this continent, although the low number of reported cases, which could be linked to under-reporting of complications. These results support the need for better strategies to diagnose and manage G6PDd in malaria field conditions. Additionally, Malaria Control Programmes in LA should not overlook this condition in their national guidelines.

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Section: Resultsmentioning

confidence: 99%

Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

Monteiro

Franca

Queiroz

et al. 2014

Malar J

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“…Previous reports of G6PDd prevalence in Colombia varied (as discussed for Brazil above) depending on the region and/or specific population assessed: higher on the coasts (12% in Buenaventura (Pacific coast) for 242 individuals [138], 14.8% in 508 individuals in Turbo (Atlantic coast) [139]), lower in the capital Bogotá (3.1% in a mestizo population) [140]. A report from 1968 that used a G6PD activity test based on discoloration of brilliant cresyl blue to survey 500 Colombian males in different sub groups based on race classification at the time found 1.2–2.5% G6PDd in white and urban groups, 13.5 and 22.2% respectively in two different groups of African descent, and interestingly, no G6PDd in indigenous people (n = 45) [141].…”

Section: Challenges For Malaria Elimination In the Regionmentioning

confidence: 99%

Malaria in Brazil, Colombia, Peru and Venezuela: current challenges in malaria control and elimination

Recht

Siqueira

Monteiro

et al. 2017

Malar J

232

244

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In spite of significant progress towards malaria control and elimination achieved in South America in the 2000s, this mosquito-transmitted tropical disease remains an important public health concern in the region. Most malaria cases in South America come from Amazon rain forest areas in northern countries, where more than half of malaria is caused by Plasmodium vivax, while Plasmodium falciparum malaria incidence has decreased in recent years. This review discusses current malaria data, policies and challenges in four South American Amazon countries: Brazil, Colombia, Peru and the Bolivarian Republic of Venezuela. Challenges to continuing efforts to further decrease malaria incidence in this region include: a significant increase in malaria cases in recent years in Venezuela, evidence of submicroscopic and asymptomatic infections, peri-urban malaria, gold mining-related malaria, malaria in pregnancy, glucose-6-phosphate dehydrogenase (G6PD) deficiency and primaquine use, and possible under-detection of Plasmodium malariae. Some of these challenges underscore the need to implement appropriate tools and procedures in specific regions, such as a field-compatible molecular malaria test, a P. malariae-specific test, malaria diagnosis and appropriate treatment as part of regular antenatal care visits, G6PD test before primaquine administration for P. vivax cases (with weekly primaquine regimen for G6PD deficient individuals), single low dose of primaquine for P. falciparum malaria in Colombia, and national and regional efforts to contain malaria spread in Venezuela urgently needed especially in mining areas. Joint efforts and commitment towards malaria control and elimination should be strategized based on examples of successful regional malaria fighting initiatives, such as PAMAFRO and RAVREDA/AMI.

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“…The region has two main transmission foci: one in the northern area, that includes the departments of Choco and Valle, and another in the southern area, that includes 10 coastal municipalities in Nariño and three in the department of Cauca. In the northern region, the population is mainly of African descent and has a high prevalence of haemoglobinopathies and Duffy-negative phenotypes and is thus refractory to P. vivax infection (MS 1997, Mendez & Moyano 2005). This phenomenon results in a larger proportion of P. falciparum cases and a concomitantly higher risk of complicated malaria and mortality.…”

Section: The Pacific Coastmentioning

confidence: 99%

Epidemiology and control of malaria in Colombia

Padilla

Uribe

Araújo³

et al. 2011

Mem. Inst. Oswaldo Cruz

123

119

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Malaria is currently one of the most serious public health problems in Colombia with an endemic/epidemic transmission pattern that has maintained endemic levels and an average of 105,000 annual clinical cases being reported over the last five years. Plasmodium vivax accounts for approximately 70% of reported cases with the remainder attributed almost exclusively to Plasmodium falciparum. A limited number of severe and complicated cases have resulted in mortality, which is a downward trend that has been maintained over the last few years. More than 90% of the malaria cases in Colombia are confined to 70 municipalities (about 7% of the total municipalities of Colombia), with high predominance (85%) in rural areas. The purpose of this paper is to review the progress of malaria-eradication activities and control measures over the past century within the eco-epidemiologic context of malaria transmission together with official consolidated morbidity and mortality reports. This review may contribute to the formulation of new antimalarial strategies and policies intended to achieve malaria elimination/eradication in Colombia and in the region.

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Defectos eritrocíticos y densidad de la parasitemia en pacientes con malaria por Plasmodium falciparum en Buenaventura, Colombia

Cited by 19 publications

References 22 publications

Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes

Malaria in Brazil, Colombia, Peru and Venezuela: current challenges in malaria control and elimination

Epidemiology and control of malaria in Colombia

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