Deficiency of the natural anticoagulant proteins in women with pregnancy related venous thromboembolism

Mitić, Gorana; Povazan, Ljubica; Lazic, Radmila; Spasic, D Snezana; Maticki-Sekulic, Milana

doi:10.2298/mpns0902053m

Cited by 15 publications

(7 citation statements)

References 16 publications

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“…Similar results were seen in Brenner's study, where a favourable outcome was recorded in 75% of pregnancies [17]. The difference in the pregnancy outcome in subgroups affected by different thrombophilias may be the result of insufficient heparin dose in the group with severe thrombophilia, such as natural anticoagulant deficiency, which has strong unfavourable influence on pregnancy [33].…”

Section: Discussionsupporting

confidence: 82%

Thromboprophylaxis implementation during pregnancy in women with recurrent foetal losses and thrombophilia

Mitić¹,

Novakov-Mikic

Povazan³

et al. 2011

Med pregl

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Recurrent foetal loss is a significant clinical problem, occurring in 1-5% of reproductive females. Inherited or acquired thrombophilia has been diagnosed in 50-65% of women with history of unexplained foetal loss. The low molecular weight heparin was applied in 24 women with inherited thrombophilia and previous recurrent foetal loss and in 6 women with primary antiphospholipid syndrome throughout their following pregnancies. The dose of low molecular weight heparin for the majority of women was 35-75 u/kg. Women with primary antiphospholipid syndrome received both low molecular weight heparin and aspirin 50-100 mg daily. Implementation of thromboprophylaxis resulted in successful pregnancy outcome in 29 out of38 pregnancies, which represents a significant improvement of pregnancy outcome in comparison to previous 81 pregnancy losses. The number of treated pregnancies in our study is small, but the rate of successful pregnancy outcomes is high (76%), indicating that low molecular weight heparin may be a promising approach to women with thrombophilia and recurrent foetal loss.

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Section: Discussionsupporting

confidence: 82%

Thromboprophylaxis implementation during pregnancy in women with recurrent foetal losses and thrombophilia

Mitić¹,

Novakov-Mikic

Povazan³

et al. 2011

Med pregl

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“…Thrombophilia is more likely to be found in women with first trimester VTE compared to the second and third trimester or postpartum. Presence of natural inhibitor deficiency is related to increased risk for antepartum VTE, which was also observed in studies of pregnancy-related VTE in our population (48,49).…”

Section: Pregnancysupporting

confidence: 87%

An Integrative Approach to the Patient with Thrombophilia / SVEOBUHVATNI PRISTUP BOLESNIKU SA TROMBOFILIJOM

Mitić¹

2014

Journal of Medical Biochemistry

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SummaryVenous thromboembolism (VTE) is a multifactorial disease that results from a conjunction of several risk factors, both inherited and acquired. The younger the person, the more risk factors are required to cause the disease. Since 1937, when the term thrombophilia was coined by Nygaard and Brown, and 1965 when it was used for the first time by Egeberg, a substantial increase in the percentage of patients with VTE and underlying thrombophilia has been reported, particularly after the discovery of the most common thrombophilic mutations, FV Leiden and FII G20210A. Presence of thrombophilia could be detected in as many as 50% of all patients with VTE. Thrombophilia testing has increased lately not only in patients with thromboses but also for other indications, however, whether the results will help in the clinical management of the patients is still unclear. Thrombo philia testing is most commonly performed in young patients with VTE, patients with recurrent episodes of VTE or with thromboses at unusual sites and in persons with positive family history. Whether the presence of thrombophilia influences the clinical management of the patient remains controversial. Patients with VTE and the recognized risk factors such are surgery, trauma, immobilization, pregnancy and the puerperium are at very low risk for recurrence, but prediction of the recurrence of VTE based on the presence of thrombophilia has not been sufficiently explored. Presence of clinical risk factors should be integrated in the strategy of VTE risk assessment. Since many risk factors, such as obesity, hypertension, dyslipidemia, diabetes and smoking are common for both arterial and venous thromboses, it has been suggested that VTE should be considered as part of a pancardiovascular syndrome, along with coronary artery disease, Kratak sadr`ajVenska tromboembolijska bolest (VTE) nastaje kao rezultat udru`enog delovanja brojnih faktora rizika, kako naslednih tako i ste~enih. U~estalost VTE je direktno povezana sa staro{}u, tako da je u mla|em uzrastu neophodno udru`eno delovanje vi{e faktora rizika za nastanak venske tromboze. Prisustvo trombofilije se mo`e utvrditi kod oko polovine bolesnika sa VTE. Dijagnostika trombofilije je sve ~e{}a u svako dnevnom laboratorijskom radu, ne samo kod bo lesnika sa trombozama ve} i za druge indikacije kao {to su komplikacije trudno}e izazvane o{te}enjem placentalne vasku larizacije, a da nije u potpunosti razja{njeno da li }e prisustvo trombofilije uticati na dalji tok le~enja i sveobuhvatni pristup bolesniku. Naj~e{}e indikacije za ispitivanje trombofilije su tromboze u mla |em uzrastu, recidivi venskih tromboza, tromboze na ne uo bi~ajenim mestima kao i postojanje tromboza kod vi{e ~la no va porodice. Dijagnostika trombofilije se naje{}e ko risti kao pomo} u proceni rizika za nastanak recidiva VTE, mada je dosada{njim ispitivanjima pokazano da samo te{ke trom bo filije, kao {to su deficit inhibitora koagulacije, homo zigotni oblik mutacije FV Leiden ili udru`eni heterozigoti za FV Lei den i FII G20210A, predst...

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“…Similar findings regarding the localization and recurrence of thrombosis were observed earlier, where isolated distal DVT was associated with a lower risk of recurrence than proximal DVT or PE [24,25]. On the other hand, inherited thrombophilic alterations, especially severe ones, such as deficiency of natural anticoagulants or combined thrombophilia are strong recurrence risk factors [26][27][28][29][30].…”

Section: Discussionsupporting

confidence: 72%

Clinical characteristics of first venous thrombosis among women under and over 45 years of age

et al. 2014

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Younger women developed more severe forms of thrombosis than the older ones. Inherited risk factor for thrombosis was detected in almost half of all young women, and in every fourth elderly women. With the exception of factor V Leiden mutation, other types of congenital thrombophilia are almost negligible among older women. Therefore, thrombophilia testing in case of first thrombosis is fully justified only in young women.

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Deficiency of the natural anticoagulant proteins in women with pregnancy related venous thromboembolism

Cited by 15 publications

References 16 publications

Thromboprophylaxis implementation during pregnancy in women with recurrent foetal losses and thrombophilia

Thromboprophylaxis implementation during pregnancy in women with recurrent foetal losses and thrombophilia

An Integrative Approach to the Patient with Thrombophilia / SVEOBUHVATNI PRISTUP BOLESNIKU SA TROMBOFILIJOM

Clinical characteristics of first venous thrombosis among women under and over 45 years of age

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