Deficient Autoregulation and Lengthening of the Diffusion Distance in the Anterior Optic Nerve Circulation in Glaucoma: An Electro-Encephalo-Dynamographic Investigation

Ulrich, W.-D.; Ulrich, Ch.; Bohne, B.-D.

doi:10.1159/000265443

Cited by 26 publications

(3 citation statements)

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“…Diese Überlegung passt zu den Untersuchungen der OPA bei den POWG-Patienten, bei denen ein eingeschränk-ter lokaler vaskulärer Kompensationsmechanismus vermutet wird [31][32][33].…”

Section: Diskussionunclassified

Okuläre Pulsamplitude bei okulärer Hypertension und verschiedenen Glaukomformen

Rückmann²,

Mittag³

1997

Ophthalmologica

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The present study was designed to investigate choroidal perfusion in primary open-angle glaucoma patients with statistically elevated (HPG) and statistically normal (NPG) intraocular pressure (IOP) and in ocular hypertensive volunteers (OHT) before and after application of topical antiglaucomatous drugs. When compared to age-matched healthy controls, ocular pulse amplitude (OPA) and IOP were significantly increased in OHT and unchanged in HPG; in NPG, the IOP was unchanged, and the OPA was significantly reduced. The topical antiglaucomatous drugs used in this study reduced IOP, but did not increase OPA. When compared to HPG and NPG, OHT subjects showed increased choroidal perfusion which may help to prevent glaucomatous optic nerve damage.

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“…Diese Überlegung passt zu den Untersuchungen der OPA bei den POWG-Patienten, bei denen ein eingeschränk-ter lokaler vaskulärer Kompensationsmechanismus vermutet wird [31][32][33].…”

Section: Diskussionunclassified

Okuläre Pulsamplitude bei okulärer Hypertension und verschiedenen Glaukomformen

Rückmann²,

Mittag³

1997

Ophthalmologica

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“…Vascular dysregulation is widespread in POAG, with abnormalities found at the optic nerve head, central retinal vessels, macula, choroid, and retrobulbar vessels . Systemic changes in POAG are exemplified as a dysregulated response to flow-mediated vasodilation at the brachial artery in both HTG and NTG, increased incidence of nocturnal systemic hypotension, decreased cerebral blood flow, carotid artery stiffness, ischemic heart disease, and increased levels of the vasoactive peptide endothelin-1, which plays a key role in vasoconstriction …”

Section: Introductionmentioning

confidence: 99%

Nailfold Capillaroscopy of Resting Peripheral Blood Flow in Exfoliation Glaucoma and Primary Open-Angle Glaucoma

et al. 2019

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laucoma is a progressive neurodegenerative ocular disease that causes visual field loss owing to damage of the retinal ganglion cells. The most common type of glaucoma in the United States, primary open-angle glaucoma (POAG), 1 has been classified into normal-tension (NTG) and high-tension glaucoma (HTG) based on the cutoff point for the statistical reference range of intraocular pressure (IOP). 2 High-tension glaucoma is associated with various risk factors, such as older age, high IOP, African descent, and positive family history. 3 Exfoliation syndrome (XFS), an age-related systemic condition, is the most common recognizable cause of open-angle glaucoma worldwide, comprising most cases in some countries. 4 Exfoliation syndrome is characterized by the production, deposition, and progressive accumulation of a white fibrillogranular extracellular material (exfoliation material) throughout the anterior segment, most prominently on the anterior lens surface, on the zonules with their resultant weakness, and on the pupillary border. Exfoliation material is also found in posterior segment vessels, including the vortex veins, posterior ciliary arteries, and central retinal vessels. It is observed microscopically in numerous organs, including the skin, heart, lungs, and kidney, primarily in the connective tissue. 5-7 In addition to obstructing fluid pathways, exfoliation material accumulation affects vascular endothelial cells as well as contractile pericytes, which wrap IMPORTANCE Systemic blood flow alterations have been described using video nailfold capillaroscopy (NFC) in high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) variants of primary open-angle glaucoma (POAG). To date, no previous studies have explored alterations in nailfold capillary blood flow in exfoliation glaucoma (XFG). OBJECTIVE To investigate the measure of peripheral blood flow as a surrogate marker of systemic vascular involvement in patients with XFG, HTG, and NTG, as well as in individuals serving as controls, using NFC.

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“…Die Drucktoleranz des Sehnervenkopfes wird auch von anderen Autoren erwähnt [33,[38][39][40]. Richardson [33] stellte die Forderung auf, Methoden zur Bestimmung der Druckto leranz zu entwickeln; die von Robert [38] benutzte Methode ist technisch schwierig, was einer klinischen Anwendung bisher im Wege stand.…”

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Wirkung von Carteolol- und Timolol-Augentropfen auf die Drucktoleranz des Sehnervenkopfes

Stodtmeister¹,

Pillunat²,

Wilmanns³

et al. 1989

Ophthalmologica

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In a planned, randomized, double blind study ocular perfusion pressures were measured before and after a 3-day regimen of 2% carteolol hydrochloride or 0.5% timolol maleate. A pressure tolerance test was also carried out. The results of this test revealed the critical pressure: it is the artificially increased intraocular pressure at which the visual function (monitored by visually evoked cortical potentials) is reduced to 20% of its initial value. The ocular prefusion pressures are affected by both drugs. They are more clearly reduced by carteolol than by timolol. The critical pressure is affected by both drugs too. After application of carteolol, the critical pressure is clearly lower than after application of timolol. The difference is statistically significant (p < 0.05).

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Deficient Autoregulation and Lengthening of the Diffusion Distance in the Anterior Optic Nerve Circulation in Glaucoma: An Electro-Encephalo-Dynamographic Investigation

Cited by 26 publications

References 1 publication

Okuläre Pulsamplitude bei okulärer Hypertension und verschiedenen Glaukomformen

Okuläre Pulsamplitude bei okulärer Hypertension und verschiedenen Glaukomformen

Nailfold Capillaroscopy of Resting Peripheral Blood Flow in Exfoliation Glaucoma and Primary Open-Angle Glaucoma

Wirkung von Carteolol- und Timolol-Augentropfen auf die Drucktoleranz des Sehnervenkopfes

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