Okuläre Pulsamplitude bei okulärer Hypertension und verschiedenen Glaukomformen

Abstract

The present study was designed to investigate choroidal perfusion in primary open-angle glaucoma patients with statistically elevated (HPG) and statistically normal (NPG) intraocular pressure (IOP) and in ocular hypertensive volunteers (OHT) before and after application of topical antiglaucomatous drugs. When compared to age-matched healthy controls, ocular pulse amplitude (OPA) and IOP were significantly increased in OHT and unchanged in HPG; in NPG, the IOP was unchanged, and the OPA was significantly reduced. The topical antiglaucomatous drugs used in this study reduced IOP, but did not increase OPA. When compared to HPG and NPG, OHT subjects showed increased choroidal perfusion which may help to prevent glaucomatous optic nerve damage.

Choroidal expansion during the water drinking test

“…The OPA has been used in many studies as an indirect measure of the choroidal perfusion [6,[15][16][17]. Differences in IOP values during systole and diastole are used to calculate an index that estimates ocular blood supply, whereas about 70-80% of it is due to the choroidal flow [6].…”

Spectral content of the intraocular pressure pulse wave: glaucoma patients versus normal subjects

“…This IOP pulse wave has been used as a means of assessing the ocular vascular status in glaucoma patients. Numerous studies have demonstrated reduced IOP pulse amplitudes and reduced pulsatile ocular blood flow in glaucoma patients compared with control subjects [11,14,15,20,21,22,24].…”

Ocular pulse amplitude in diabetes mellitus

“…Increased choroidal perfusion as noted in ocular hypertensive patients22 24 and following application of nifedipine25 26 and dorzolamide27 28 may be interpreted as a protective mechanism.…”