Deficient production of tyramine and octopamine in cases of depression

Sandler, M.; Ruthven, C.R.J.; Goodwin, B.L.; Reynolds, Gavin P.; Rao, V.A. Rama; Coppen, Alec

doi:10.1038/278357a0

Cited by 94 publications

(21 citation statements)

References 10 publications

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“…In mammals, trace amines, such as TA/OA, have been implicated in a number of disorders, including depression, schizophrenia, and ADHD (Sandler et al, 1979;Davis and Boulton, 1994;Kusaga, 2002). Recently, a novel family of TAARs has been identified; however, in contrast to the classical BAs, much less is known about trace amine-mediated signaling.…”

Section: Discussionmentioning

confidence: 99%

Tyramine and Octopamine Independently Inhibit Serotonin-Stimulated Aversive Behaviors inCaenorhabditis elegansthrough Two Novel Amine Receptors

Wragg¹,

Hapiak²,

Miller³

et al. 2007

J. Neurosci.

115

146

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Biogenic amines modulate key behaviors in both vertebrates and invertebrates. In Caenorhabditis elegans, tyramine (TA) and octopamine (OA) inhibit aversive responses to 100%, but not dilute (30%) octanol. TA and OA also abolish food-and serotonin-dependent increases in responses to dilute octanol in wild-type but not tyra-3(ok325) and f14d12.6(ok371) null animals, respectively, suggesting that TA and OA modulated responses to dilute octanol are mediated by separate, previously uncharacterized, G-protein-coupled receptors. TA and OA are high-affinity ligands for TYRA-3 and F14D12.6, respectively, based on their pharmacological characterization after heterologous expression. f14d12.6::gfp is expressed in the ASHs, the neurons responsible for sensitivity to dilute octanol, and the sra-6-dependent expression of F14D12.6 in the ASHs is sufficient to rescue OA sensitivity in f14d12.6(ok371) null animals. In contrast, tyra-3::gfp appears not to be expressed in the ASHs, but instead in other neurons, including the dopaminergic CEP/ADEs. However, although dopamine (DA) also inhibits 5-HT-dependent responses to dilute octanol, TA still inhibits in dop-2; dop-1; dop-3 animals that do not respond to DA and cat-2(tm346) and Pdat-1::ICE animals that lack significant dopaminergic signaling, suggesting that DA is not an intermediate in TA inhibition. Finally, responses to TA and OA selectively desensitize after preexposure to the amines. Our data suggest that although tyraminergic and octopaminergic signaling yield identical phenotypes in these olfactory assays, they act independently through distinct receptors to modulate the ASH-mediated locomotory circuit and that C. elegans is a useful model to study the aminergic modulation of sensory-mediated locomotory behaviors.

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Section: Discussionmentioning

confidence: 99%

Tyramine and Octopamine Independently Inhibit Serotonin-Stimulated Aversive Behaviors inCaenorhabditis elegansthrough Two Novel Amine Receptors

Wragg¹,

Hapiak²,

Miller³

et al. 2007

J. Neurosci.

115

146

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“…In invertebrates, the TAs octopamine (OCT) and TYR are bona fide neurotransmitters that act to modulate metabolism and skeletal muscles (Axelrod and Saavedra, 1977;Roeder, 2005), but the role of TAs in mammalian physiology is unclear. Some evidence suggests that decreased levels of TYR, OCT, and PEA are found in patients with clinical depression, and elevated levels of PEA exist in patients with schizophrenia (Sandler et al, 1979;Davis and Boulton, 1994).…”

mentioning

confidence: 99%

Trace Amine-Associated Receptor 1 Displays Species-Dependent Stereoselectivity for Isomers of Methamphetamine, Amphetamine, and Para-Hydroxyamphetamine

Reese¹,

Bunzow²,

Arttamangkul³

et al. 2007

J Pharmacol Exp Ther

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The synthetic amines methamphetamine (METH), amphetamine (AMPH), and their metabolite para-hydroxyamphetamine (POHA) are chemically and structurally related to the catecholamine neurotransmitters and a small group of endogenous biogenic amines collectively referred to as the trace amines (TAs). Recently, it was reported that METH, AMPH, POHA, and the TAs para-tyramine (TYR) and ␤-phenylethylamine (PEA) stimulate cAMP production in human embryonic kidney (HEK)-293 cells expressing rat trace amine-associated receptor 1 (rTAAR1). The discovery that METH and AMPH activate the rTAAR1 motivated us to study the effect of these drugs on the mouse TAAR1 (mTAAR1) and a human-rat chimera (hrChTAAR1). Furthermore, because S-(ϩ)-isomers of METH and AMPH are reported to be more potent and efficacious in vivo than R-(Ϫ), we determined the enantiomeric selectivity of all three species of TAAR1. In response to METH, AMPH, or POHA exposure, the accumulation of cAMP by HEK-293 cells stably expressing different species of TAAR1 was concentration-and isomer-dependent. EC 50 values for S-(ϩ)-METH were 0.89, 0.92, and 4.44 M for rTAAR1, mTAAR1, and h-rChTAAR1, respectively. PEA was a potent and full agonist at each species of TAAR1, whereas TYR was a full agonist for the rodent TAAR1s but was a partial agonist at h-rChTAAR1. Interestingly, both isomers of METH were full agonists at mTAAR1 and h-rChTAAR1, whereas both were partial agonists at rTAAR1. Taken together, these in vitro results suggest that, in vivo, TAAR1 could be a novel mediator of the effects of these drugs.

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“…Moreover, it was known that disturbances in tyramine metabolism might be involved in the pathophysiology of some neuropsychiatric disorders (12), and some studies indicated that tyramine modulated neural response patterns to catecholamine transmitters (5). Thus, "only-AADC "-LI cells might produce "trace amines" and be related to certain mental diseases.…”

Section: Discussionmentioning

confidence: 99%

Some neurons of the mouse cortex and caudoputamen contain aromatic L-amino acid decarboxylase but not monoamines.

Komori

Fujii

Karasawa

et al. 1991

Acta Histochem. Cytochem

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Deficient production of tyramine and octopamine in cases of depression

Cited by 94 publications

References 10 publications

Tyramine and Octopamine Independently Inhibit Serotonin-Stimulated Aversive Behaviors inCaenorhabditis elegansthrough Two Novel Amine Receptors

Tyramine and Octopamine Independently Inhibit Serotonin-Stimulated Aversive Behaviors inCaenorhabditis elegansthrough Two Novel Amine Receptors

Trace Amine-Associated Receptor 1 Displays Species-Dependent Stereoselectivity for Isomers of Methamphetamine, Amphetamine, and Para-Hydroxyamphetamine

Some neurons of the mouse cortex and caudoputamen contain aromatic L-amino acid decarboxylase but not monoamines.

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