Deficient vitamin B12 levels are associated with increased delirium incidence in critically ill patients

Vosouqi, Mohammad; Abbasi, Saeed; Farsaei, Shadi

doi:10.1016/j.clnesp.2023.02.014

Cited by 2 publications

(3 citation statements)

References 31 publications

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“…Ataxia, memory loss, delirium, and peripheral neuropathy are some neurological abnormalities 16 . Vitamin B 12 deficiency prevalence in adults admitted to critical care ranges from 2% to 35%, depending on the study population 17–20 . However, vitamin B 12 deficiency prevalence may be underestimated in critically ill patients.…”

Section: Introductionmentioning

confidence: 99%

“…Serum vitamin B 12 levels increase in the presence of inflammation, potentially masking suboptimal vitamin B 12 status 21 . Identification and treatment of vitamin B 12 deficiency may address potential hematological and neurological symptoms including delirium 20 . Healthcare providers working in the intensive care unit (ICU) should be aware of vitamin B 12 's role both in deficiency states and as an investigative treatment for critically ill patients with refractory, vasodilatory shock.…”

Section: Introductionmentioning

confidence: 99%

“…16 Vitamin B 12 deficiency prevalence in adults admitted to critical care ranges from 2% to 35%, depending on the study population. [17][18][19][20] However, vitamin B 12 deficiency prevalence may be underestimated in critically ill patients. Serum vitamin B 12 levels increase in the presence of inflammation, potentially masking suboptimal vitamin B 12 status.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Treatment of refractory shock with vitamin B₁₂: A narrative review

Wedemire,

Samavat,

Newkirk

et al. 2023

Nut in Clin Prac

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High‐dose vitamin B12 is a potential treatment for patients with vasodilatory shock that is refractory to other therapies. Vasodilatory shock is characterized by low blood pressure and low systemic vascular resistance. Nitric oxide and hydrogen sulfide, two potential targets of high‐dose vitamin B12 given as hydroxocobalamin, facilitate this syndrome. This review explores the relationship between high‐dose vitamin B12 and hemodynamic outcomes in adults with vasodilatory shock and provides an update on the literature since a 2019 review on this topic. A literature search of studies published in the past 5 years was conducted in the CINAHL, PubMed, Cochrane, and EMBASE databases in May 2023. After assessing for eligibility, eight studies met this review's inclusion criteria. Seven of the eight studies reported decreased vasopressor requirements for part or all of the study samples after receiving a hydroxocobalamin infusion. However, not all patients responded to hydroxocobalamin. These findings are limited by patient selection and differences in the timing of vasopressor requirement and blood pressure outcome assessments. The current evidence is promising as to whether vitamin B12, given as a hydroxocobalamin infusion, may improve hemodynamic outcomes in vasodilatory shock, but the evidence is of low quality. The use of hydroxocobalamin to treat refractory, vasodilatory shock remains investigative. Larger randomized controlled trials are required to elucidate the role of vitamin B12 in treating refractory, vasodilatory shock, including in conjunction with other alternative therapies such as methylene blue and corticosteroids.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%