Deficit of Suppressor T Cells in Active Multiple Sclerosis

Bach, Marie‐Anne; Tournier, Elizabeth; Phan-Dinh-Tuy, Françoise; Chatenoud, Lucienne; Bach, Jean‐François; Martin, C J; Degos, Jean‐Denis

doi:10.1016/s0140-6736(80)92480-0

Cited by 187 publications

(41 citation statements)

References 12 publications

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“…multiple sclerosis, where the OKT4/OKT 8 lymphocyte ratio was found to be increased with reference to a healthy control group. The increase was greatest at times of exacerbation, which may indicate a positive correlation between OKT4/OKT8 ratios and disease activity [26]. Similarly, in this study of Type 1 diabetes, we found OKT4/OKT 8 ratios were most elevated at the time of diagnosis, failing significantly thereafter at the 3-week and 5-month studies.…”

Section: Discussionsupporting

confidence: 77%

T lymphocyte subsets in patients with newly diagnosed Type 1 (insulin-dependent) diabetes: A prospective study

Buschard¹,

Røpke

Madsbad³

et al. 1983

Diabetologia

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Summary. T lymphocyte subsets in peripheral blood from 11 newly diagnosed Type 1 (insulin-dependent) diabetic patients were studied prospectively at three time intervals: as soon as possible after diagnosis, 3 weeks and 5 months later. Lymphocytes were marked with monoclonal OKT antibodies and examined in a fluorescence-activated cell sorter. The percentage of T lymphocytes (OKT 3) did not change significantly at the three study times. The percentage of helper/inducer T cells (OKT 4) was high the first week after diagnosis, but decreased at the 5-month examination (p< 0.05). The percentage of suppressor/cytotoxic T cells (OKT 8) was low at diagnosis but increased at 3 weeks (p< 0.02) and 5 months (p< 0.01). The ratio OKT 4/OKT 8 lymphocytes was 2.28 at diagnosis, decreasing to 1.77 at 3 weeks and 1.87 at 5 months, compared with 1.46 for 16 age-matched control subjects. There was no significant change in the absolute number of lymphocytes. It is concluded that the distribution of T cell subsets was abnormal at the time of diagnosis, but changed towards normal within a few weeks, after which there was no significant change at 5 months. It is as yet unknown whether the high proportion of helper/inducer T cells and/or the low percentage of suppressor/cytotoxic T cells at diagnosis favour immune reactions involved in the pathogenesis of Type 1 diabetes.

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Section: Discussionsupporting

confidence: 77%

T lymphocyte subsets in patients with newly diagnosed Type 1 (insulin-dependent) diabetes: A prospective study

Buschard¹,

Røpke

Madsbad³

et al. 1983

Diabetologia

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“…One of the most consistent and attractive findings relates to suppressor cells; most studies agree that circulating suppressor cell numbers (measured by membrane markers) (5,(8)(9)(10)(11) and suppressor cell function (determined in various in vitro systems) (4,6,7) are altered during the acute phases of MS. It is theorized that a loss of suppression in MS may indicate a deregulation of immune "homeostasis" in the CNS, permitting an uncontrolled immune response to self or viral antigens (10,11).…”

Section: Introductionmentioning

confidence: 96%

“…The plethora of reports of abnormal humoral immunity in MS-including raised titers of antibodies to measles and other viruses (1) and antibodies to several CNS components (2, 3)-has been followed in recent years by reports of cellular immune abnormalities (2,(4)(5)(6)(7)(8)(9)(10)(11). One of the most consistent and attractive findings relates to suppressor cells; most studies agree that circulating suppressor cell numbers (measured by membrane markers) (5,(8)(9)(10)(11) and suppressor cell function (determined in various in vitro systems) (4,6,7) are altered during the acute phases of MS. It is theorized that a loss of suppression in MS may indicate a deregulation of immune "homeostasis" in the CNS, permitting an uncontrolled immune response to self or viral antigens (10,11).…”

Section: Introductionmentioning

confidence: 99%

“…10-15 ml of blood was obtained from patients within an hour of lumbar puncture. PB mononuclear cells were isolated and phenotyped as already described (11,16).…”

Section: Introductionmentioning

confidence: 99%

“…When possible, a OKT4+/OKT8+ index was computed from the OKT4+ and OKT8+ percentages. A helper/suppressor cell ratio is thought to diminish the influence of nonlymphoid contaminating cells on the absolute percentage of labeled cells (10,11). Data were analyzed with Student's two-tailed t test.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Monoclonal antibody-defined immunoregulatory cells in multiple sclerosis cerebrospinal fluid.

Cashman¹,

Martin²,

Eizenbaum³

et al. 1982

J. Clin. Invest.

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A B S T R A C T To determine if previously reported peripheral blood suppressor cell defects are also found in the central nervous system (CNS) of patients with multiple sclerosis (MS), we studied cerebrospinal fluid (CSF) and peripheral blood lymphocytes from 40 MS patients and 15 patients with other neurological diseases. With an indirect immunofluorescence technique using the OKT series of monoclonal antibodies (OKT4, marking helper/inducer cells, OKT5 and OKT8 marking suppressor/cytotoxic cells, and OKT3 marking all peripheral T cells) we found that MS patients tested in the first 2 wk of exacerbation had invariably diminished CSF suppressor/cytotoxic cells, which was followed by an elevation of these cells in the 3rd wk of exacerbation. Repeat studies of three patients showed that perturbations of CSF suppressor/cytotoxic cells were dependent on clinical status. These observations add to the accumulating data that suggest altered immunity in the pathogenesis of MS.

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Immunosuppression and Plasmapheresis in Chronic Progressive Multiple Sclerosis

Hauser

1983

Arch Neurol

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Deficit of Suppressor T Cells in Active Multiple Sclerosis

Cited by 187 publications

References 12 publications

T lymphocyte subsets in patients with newly diagnosed Type 1 (insulin-dependent) diabetes: A prospective study

T lymphocyte subsets in patients with newly diagnosed Type 1 (insulin-dependent) diabetes: A prospective study

Monoclonal antibody-defined immunoregulatory cells in multiple sclerosis cerebrospinal fluid.

Immunosuppression and Plasmapheresis in Chronic Progressive Multiple Sclerosis

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