Deficits in working but not reference memory in adult rats in which limbic seizures had been induced before weaning: Implications for early brain injuries

Kostakos, Maria; Persinger, Michael A.; Peredery, Oksana

doi:10.1016/0304-3940(93)90266-n

Cited by 6 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, there are no reports showing neuronal loss in limbic structures in rats younger than postnatal day 14 (P14) at the time of SE (Stafstrom et al ., 1992; Toth et al ., 1998; Fernandes et al ., 1999; Sperber et al ., 1999). There are several reports, however, of neuronal damage, mossy fibre sprouting, cognitive impairment and development of epilepsy in rats exposed to SE at ≈ P20 (Stafstrom et al ., 1992, 1993; Kostakos et al ., 1993; Liu et al ., 1994; Sankar et al ., 1998, 2000; Fernandes et al ., 1999; Dubé et al ., 2000b; Cha et al ., 2002; Rutten et al ., 2002; Cilio et al ., 2003; Raol et al ., 2003). Only recently, Wu et al (2001) found spatial memory deficits in rats surviving LiCl–pilocarpine‐induced SE at P14.…”

Section: Introductionmentioning

confidence: 99%

Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis

Kubová

Mareš

Suchomelova

et al. 2004

Eur J of Neuroscience

147

115

View full text Add to dashboard Cite

It remains under dispute whether status epilepticus (SE) in the perinatal period or early childhood or the underlying neuropathology is the cause of functional impairment later in life. The present study examined whether SE induced by LiCl-pilocarpine in normal immature brain (at the age of 12 or 25 days; P12 or P25) causes cognitive decline and epileptogenesis, and the data were compared to those of rats undergoing SE as adults. Rats in the P12 group had impaired memory (repeated exposure to open-field paradigm) and emotional behaviour (lower proportion of open-arm entries and higher incidence of risk assessment period in elevated plus-maze) when assessed 3 months after SE, although not as severe as in the older age groups. Importantly, video-electroencephalography monitoring 3 months after SE demonstrated that 25% of rats in the P12 and 50% in P25 group developed spontaneous seizures. Only nonconvulsive seizures (ictal activity in hippocampus accompanied by automatisms) were recorded in the P12 group whereas rats in the P25 group exhibited clonic convulsions. The present findings indicate that SE is harmful to the immature brain as early as P12, which might be compared with early infancy in humans.

show abstract

Section: Introductionmentioning

confidence: 99%

Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis

Kubová

Mareš

Suchomelova

et al. 2004

Eur J of Neuroscience

147

115

View full text Add to dashboard Cite

show abstract

“…after the lithium. Kostakos, Persinger, and Peredery (1993) reported that rats in which limbic seizures had been induced before weaning exhibited deficits in worktng memory but not in reference memory for a spatial task. The present study was designed to extend this research by restlng adult rats that had been seized before weaning and directly comparing them to same-age, Ltter mates seized as adults.…”

mentioning

confidence: 99%

Working Memory and Reference Memory in Adult Rats following Limbic Seizures Induced at 21 or 90 Days of Age

Kinoshameg¹,

Persinger²

2002

Psychol Rep

View full text Add to dashboard Cite

Rats were either seized or not seized at 21 days of age (weaning) or at 90 days of age with a single systemic injection of lithium (3 mEq/kg) and pilocarpine (30 mg/kg). When tested as adults (120 days of age) for spatial memory in the Olton radial maze, the rats that had been seized as adults exhibited about five times more working (short-term) memory errors than the other three groups which did not differ significantly from one another. The numbers of errors for long-term (reference) memory did not differ significantly among the four groups. The deficits in working memory for the group seized as weanlings and reported previously were not replicated. One possible explanation for this discrepancy might be differential effects upon brain organization associated with seizures evoked by injecting the pilocarpine 24 hr. rather than 4 hr. after the lithium.

show abstract

The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions

et al. 2016

View full text Add to dashboard Cite

Deficits in working but not reference memory in adult rats in which limbic seizures had been induced before weaning: Implications for early brain injuries

Cited by 6 publications

References 20 publications

Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis

Status epilepticus in immature rats leads to behavioural and cognitive impairment and epileptogenesis

Working Memory and Reference Memory in Adult Rats following Limbic Seizures Induced at 21 or 90 Days of Age

The frequency of spontaneous seizures in rats correlates with alterations in sensorimotor gating, spatial working memory, and parvalbumin expression throughout limbic regions

Contact Info

Product

Resources

About