Defining skin cancer local recurrence

Wysong, Ashley; Higgins, Shauna; Blalock, Travis W.; Ricci, Dominic; Nichols, Rich; Smith, Franki Lambert; Kossintseva, Irèn

doi:10.1016/j.jaad.2019.03.087

Cited by 21 publications

(17 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…BCC recurrence was identified by reviewing patient records on the ECM from 1 September 2016 to 31 August 2019. Recurrence was defined as “possible local recurrence” when histologically confirmed BCC arose within the scar of a previously excised BCC [ 12 ]. The principal investigator (JG) collated the anonymised data in a Microsoft Excel spreadsheet.…”

Section: Methodsmentioning

confidence: 99%

A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa

Gallo

Schneider

Wet

et al. 2022

Journal of Skin Cancer

View full text Add to dashboard Cite

Background. Basal cell carcinoma (BCC) is an important malignancy in sub-Saharan Africa. There is a paucity of data regarding BCC in South Africa. Aims. To describe the clinicopathological features of patients presenting with BCC in a cohort of South African patients. Methods. This retrospective descriptive study reviewed the medical records of 149 patients with BCC who attended the dermatology clinic at Tygerberg Academic Hospital from September 2015 to August 2016. Demographic and clinical data of those patients with histologically proven BCC were retrieved from clinical records. The data included the assessment for BCC recurrence after three years (September 2016–August 2019). Results. Of 390 patients, 155 (39.7%) had histologically confirmed BCCs. Complete medical records were available for 149 of these patients, and most were male (55.7%) and white (85.9%) with a median age of 70 years. Most patients had their BCC lesions for 12 months (43.1%) before diagnosis. BCCs were mostly located on the head and neck area (58.1%). In most patients (72.0%), a diagnostic punch biopsy confirmed BCC. Plastic surgeons subsequently excised the BCC lesions in 74.0% of these patients. The most common histological subtype was nodular BCC (74.0%). The National Comprehensive Cancer Network (NCCN) risk of recurrence was approximately evenly distributed between high- (54.1%) and low-risk groups (45.9%). The major high-risk feature was the location (36.6%). Histologically confirmed BCC recurrence occurred in 9 of the 149 patients (3.7%) over three years. Conclusions. BCC represents a high burden of disease in our setting. Compared to existing studies, the BCCs in this study are clinically and histologically similar to international reports.

show abstract

Section: Methodsmentioning

confidence: 99%

A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa

Gallo

Schneider

Wet

et al. 2022

Journal of Skin Cancer

View full text Add to dashboard Cite

show abstract

“…These inconsistencies, however, are not limited to retrospective reviews, but rather, they span the skin cancer literature and have led to the publication of guidelines for defining skin cancer recurrence prospectively. 27 An additional limitation of this study is the diverse treatment modalities that were used, highlighting the lack of standardization for management of high-risk SCC. Although documented, there are too many combinations and variations in treatment to perform meaningful statistical analysis on this component.…”

Section: Discussionmentioning

confidence: 99%

Recurrence Status, Perineural Invasion, and Hypothyroidism Are Associated With Lymph Node Metastasis in Cutaneous Squamous Cell Carcinoma: A Case–Control Study

et al. 2022

Self Cite

View full text Add to dashboard Cite

BACKGROUND Lymph node metastasis is a critical prognostic indicator for mortality in patients with cutaneous squamous cell carcinoma (SCC). OBJECTIVE To identify and characterize key risk factors for SCC lymph node metastasis. METHODS This was a multi-institutional, case-control study of 65 cutaneous SCCs with known lymph node metastasis matched with 195 cutaneous SCCs without lymph node metastasis (3:1 matching). The cases and controls were matched by anatomic location, age, and sex. Odds ratios (ORs) and their 95% confidence intervals (CIs) were generated to determine the association between specific risk factors and lymph node metastasis in a multivariate analysis. RESULTS Recurrent tumors (p , .001), perineural invasion (p , .001), lymphovascular invasion (p 5 .002), size of 2 cm or greater (p 5 .008), and hypothyroidism (p 5 .03) were significantly more common in the lymph node metastasis cohort. Recurrence (OR 6.3, 95% CI 2.6-15.3), perineural invasion (OR 4.5, 95% CI 1.7-11.8), and hypothyroidism (OR 2.7, 95% CI 1.04-7.0) remained significant on performing a multivariate analysis. CONCLUSION Lymph node metastasis in SCC is associated with recurrence, perineural invasion, lymphovascular invasion, size of 2 cm or greater, and hypothyroidism. Clinical consideration of these findings within the context of current staging systems may help improve patient outcomes.

show abstract

“…Skin cancer is considered the most prevalent cancer type globally and in the United States, with a continuously increasing prevalence and mortality growth rate [ 9 , 10 , 11 , 12 ]. Skin cancer is characterized by an imbalance in cell homeostasis and excessive cell proliferation as a result of cancer-associated gene mutations, such as skin proto-oncogenes and tumor suppressors within skin cells [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Depending on the type of cells affected, there are two major types of skin cancer, namely non-melanoma and cutaneous melanoma [ 12 ]. On one hand, non-melanoma skin cancers, predominantly comprising basal cell carcinoma and cutaneous squamous cell carcinoma, originate from the keratinocytes within the epidermis and account for approximately five million new cases and 65,000 associated deaths yearly [ 10 , 11 , 12 , 13 ]. Other types of non-melanoma skin cancers include Merkel cell carcinoma, Kaposi sarcoma, dermatofibrosarcoma protuberans, primary cutaneous B-cell lymphoma, sebaceous carcinoma, and atypical fibroxanthoma, which are significantly rarer [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Other types of non-melanoma skin cancers include Merkel cell carcinoma, Kaposi sarcoma, dermatofibrosarcoma protuberans, primary cutaneous B-cell lymphoma, sebaceous carcinoma, and atypical fibroxanthoma, which are significantly rarer [ 13 , 14 ]. On the other hand, melanoma originates from melanocytes within the deepest layer of the epidermis and, although its prevalence is considerably lower, it has the worst prognosis, with 280,000 new cases and 60,000 associated deaths reported yearly [ 10 , 11 , 12 , 13 ]. Moreover, the incidence of skin cancers is continuously increasing, which could be associated with higher UV radiation exposure [ 11 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Regenerative Wound Dressings for Skin Cancer

Pavel

Chircov

Rădulescu

et al. 2020

Cancers

View full text Add to dashboard Cite

Skin cancer is considered the most prevalent cancer type globally, with a continuously increasing prevalence and mortality growth rate. Additionally, the high risk of recurrence makes skin cancer treatment among the most expensive of all cancers, with average costs estimated to double within 5 years. Although tumor excision is the most effective approach among the available strategies, surgical interventions could be disfiguring, requiring additional skin grafts for covering the defects. In this context, post-surgery management should involve the application of wound dressings for promoting skin regeneration and preventing tumor recurrence and microbial infections, which still represents a considerable clinical challenge. Therefore, this paper aims to provide an up-to-date overview regarding the current status of regenerative wound dressings for skin cancer therapy. Specifically, the recent discoveries in natural biocompounds as anti-cancer agents for skin cancer treatment and the most intensively studied biomaterials for bioactive wound dressing development will be described.

show abstract

Defining skin cancer local recurrence

Cited by 21 publications

References 80 publications

A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa

A Profile and Three-Year Follow-Up of Patients with Basal Cell Carcinoma in the Western Cape, South Africa

Recurrence Status, Perineural Invasion, and Hypothyroidism Are Associated With Lymph Node Metastasis in Cutaneous Squamous Cell Carcinoma: A Case–Control Study

Regenerative Wound Dressings for Skin Cancer

Contact Info

Product

Resources

About