Defining the Field of Sequence‐Controlled Polymers

Lutz, Jean‐François

doi:10.1002/9783527806096.ch1

Cited by 24 publications

(27 citation statements)

References 142 publications

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“…4,41 However, often only well-defined oligomers were provided and the synthesis of larger sequence-defined polymers remains challenging. 42 Sequence-regulated polymers became a promising detour on the way to next generation precision polymers and precision materials. 43 Controlled chain growth polymerizations combine both access to higher molecular weight polymers and functionality positioning.…”

Section: Introductionmentioning

confidence: 99%

Molecular Bottle Brushes with Positioned Selenols: Extending the Toolbox of Oxidative Single Polymer Chain Folding with Conformation Analysis by Atomic Force Microscopy

Schué

Kopyshev

Lutz

et al. 2019

Journal of Polymer Science

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A synthesis route to controlled and dynamic single polymer chain folding is reported. Sequence‐controlled macromolecules containing precisely located selenol moieties within a polymer chain are synthesized. Oxidation of selenol functionalities lead to diselenide bridges and induces controlled intramolecular crosslinking to generate single chain collapse. The cyclization process is successfully characterized by SEC as well as by 1H NMR and 2D HSQC NMR spectroscopies. In order to gain insight on the molecular level to reveal the degree of structural control, the folded polymers are transformed into folded molecular brushes that are known to be visualizable as single molecule structures by AFM. The “grafting onto” approach is performed by using triazolinedione−diene reaction to graft the side chain polymers. A series of folded molecular brushes as well as the corresponding linear controls are synthesized. AFM visualization is proving the cyclization of the folded backbone by showing globular objects, where non‐folded brushes show typical worm‐like structures. © 2019 Wiley Periodicals, Inc. J. Polym. Sci. 2020, 58, 154–162

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Section: Introductionmentioning

confidence: 99%

Molecular Bottle Brushes with Positioned Selenols: Extending the Toolbox of Oxidative Single Polymer Chain Folding with Conformation Analysis by Atomic Force Microscopy

Schué

Kopyshev

Lutz

et al. 2019

Journal of Polymer Science

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“…However, synthetic polymers are still inferior to natural biological macromolecules in terms of monomer sequence. To address this, many recent studies have reported new methods for the synthesis of polymers with controlled monomer sequences [ 5 , 6 , 7 , 8 , 9 , 10 ] that show different thermal responses in solution and different phase transitions in the bulk relative to the corresponding random copolymer [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Well-Defined Alternating Copolymer Composed of Ethylmaleimide and Hydroxy-Functionalized Vinyl Ether by RAFT Polymerization and Their Thermoresponsive Properties

Motoyanagi

Oguri

2020

Polymers

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Here we report the controlled synthesis of alternating copolymers by reversible addition-fragmentation chain transfer (RAFT) polymerization of hydroxy-functionalized vinyl ether (DEGV) and ethylmaleimide (EtMI) using dithiocarbonate derivative (CPDB) as the RAFT reagent. The resulting alternating copolymer poly[ethylmaleimide-alt-(diethylene glycol mono vinyl ether)] (poly(MalMI-alt-DEGV)) had a relatively narrow molecular weight distribution (Mw/Mn < 1.4). These polymers are fully soluble in cold water (5 °C) and an aqueous solution of poly(MalMI-alt-DEGV) became turbid upon heating (using an incident wavelength of 600 nm and 1.0 mg mL−1 (0.1 wt %) polymer concentration), indicating phase separation above the cloud point temperature (Tcp). The Tcp of the polymer solution ranged from 15–35 °C, depending on the molecular weight and molecular weight distribution of the polymer.

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“…[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] In this context, it is important to distinguish between the terms "sequence-controlled" and "sequence-defined", whereby only the latter offers unique, monodisperse macromolecules, while sequence-controlled systems still show dispersity in many aspects. 22,23 Most sequence-defined macromolecules tend to be oligomers as opposed to polymers and thus extending reachable degrees of polymerisation as well as scalability are issues of high relevance. Conventional polymerisation techniques on the other hand are scalable, but lead to irregularity and dispersity and thus, at best, can be considered to be sequence-controlled, depending on the polymerisation mechanism.…”

Section: Introductionmentioning

confidence: 99%

Direct comparison of solution and solid phase synthesis of sequence-defined macromolecules

et al. 2019

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Defining the Field of Sequence‐Controlled Polymers

Cited by 24 publications

References 142 publications

Molecular Bottle Brushes with Positioned Selenols: Extending the Toolbox of Oxidative Single Polymer Chain Folding with Conformation Analysis by Atomic Force Microscopy

Molecular Bottle Brushes with Positioned Selenols: Extending the Toolbox of Oxidative Single Polymer Chain Folding with Conformation Analysis by Atomic Force Microscopy

Synthesis of Well-Defined Alternating Copolymer Composed of Ethylmaleimide and Hydroxy-Functionalized Vinyl Ether by RAFT Polymerization and Their Thermoresponsive Properties

Direct comparison of solution and solid phase synthesis of sequence-defined macromolecules

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