Defining the Optimal Treatment of Locally Advanced Esophageal Cancer: A Systematic Review and Decision Analysis

Oesophageal cancer: an overview of a deadly disease

“…A recent study combined a meta-analysis of survival benefi t with decision analysis evaluating relative risk for mortality and quality of life. This study demonstrated a very small increase in quality adjusted life years for neoadjuvant chemoradiation therapy and surgery compared with surgery alone, and concluded that surgery alone may be the preferred treatment in advanced OC (74). On a global basis, it appears that neoadjuvant therapy will likely become standard of care in resource rich areas (such as westernized countries where AC is more common), while surgical resection alone will remain the cornerstone of treatment for much of the world where OSCC predominates.…”

“…In many of these studies, morbidity (up to 80%) and mortality (2%-8%) associated with adjuvant treatment has been signifi cant (73). A number of different meta-analyses have been performed attempting to combine the results of these relatively small randomized series (74,75). In general, these meta-analyses have failed to show any signifi cant improvement in survival with adjuvant treatment.…”

The value of post-neoadjuvant therapy PET-CT in the detection of interval metastases in esophageal carcinoma

“…10 Initial staging includes a thorough search for metastatic disease however when patients are treated with neoadjuvant therapy with an extended interval until resection, routine restaging is currently not the standard of care.…”

Variations in the Histopathologic Type of Esophageal Carcinoma Between the United States of America and India

“…The reported 5-year survival is in the range of 15-20 % for patients in the United States (US) [2,3]. Behavioral factors such as diet, physical activity, smoking, and drinking behavior influence the distribution of diseases, including esophageal carcinoma, in a population [4,5].…”