Defining umbilical cord blood stem cells

Ali, Hamad; Al-Mulla, Fahd

doi:10.4236/scd.2012.21003

Cited by 20 publications

(19 citation statements)

References 62 publications

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“…6,7 Recent researches in stem cells have indicated that umbilical cord blood may be a significant source of laboratory sample for analysis of fetal haematologic parameters instead of newborn blood which is very difficult to obtain. The effect of maternal diseases like diabetes, anaemia and hypertension on the fetal haematology may also be evident in the umbilical cord blood.…”

Section: Discussionmentioning

confidence: 99%

Hematological profile including alkali resistant hemoglobin of neonates at birth using cord blood in relation to gestational age and maternal diseases

2016

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Background: The importance of complete hemogram along with the hematological indices in the diagnosis of neonatal health cannot be overemphasized. There is a severe paucity of relevant data regarding neonatal hematological profile in relation to gestational age and maternal diseases in this part of the country. With this perspective, the authors intended to do a pilot study to analyse the haematological profile of neonates of different gestational ages and different maternal diseases born in a teriary care hospital in Eastern India.Methods: This is a cross sectional study design based on cord blood sample of newborns and their mothers recruited from those admitted in the gynae and obstetric department in IPGME&R. The umbilical cord blood was collected from the newborn babies and then examined for different haematological parameters. The data obtained was statistically analysed.Results: While there has been a sequential rise of fetal red cell count, hemoglobin and the total white cell count neutrophils with gestational age, the mean corpuscular cell volume decreased. All these values were comprised to varying degrees in maternal diseases except for nucleated rell blood cells which conspicuously increased in neonates of diabetic mothers.Conclusions: In this study, a small attempt was made to assess the haematological profile (including alkali resistant hemoglobin) of the newborns in relation to gestational age and maternal diseases in the population attending a tertiary care hospital in Eastern India.

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Section: Discussionmentioning

confidence: 99%

Hematological profile including alkali resistant hemoglobin of neonates at birth using cord blood in relation to gestational age and maternal diseases

2016

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“…These cells are capable of differentiating into mesodermal cell lineages, including adipogenic, chondrogenic and osteogeneic cells (Bieback et al 2004;Ali and Al-Mulla 2012). These cells can be identified by their lack of typical hematopoietic antigens, CD34, CD45, and CD133.…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

“…Developed from the allantois and fetal yolk sac, the umbilical cord allows for nourishment to pass from mother to fetus (Ali and Al-Mulla 2012). The umbilical cord contains three blood vessels, two arteries and one vein, and is approximately 6 cm around and 50-60 cm long.…”

Section: Collection and Storage Of Cord Blood Cellsmentioning

confidence: 99%

“…These cells can be identified by their lack of typical hematopoietic antigens, CD34, CD45, and CD133. Although MSCs are found in low numbers in UCB, they are highly proliferative (Ali and Al-Mulla 2012). The MSC can be isolated from the MNC fraction, forming fibroblastoid cells in culture.…”

Section: Mesenchymal Stem Cellsmentioning

confidence: 99%

“…The HSCs are characterized by their expression of CD34, CD45, and CD133, which are hematopoietic lineage-specific antigens (McGuckin et al 2003;Ali and Al-Mulla 2012). HSCs are not only present in UCB, but also seemed to be in a very early stage of development, as they maintain a very high proliferation rate even after over 20 years of cryopreservation (Broxmeyer et al 2011).…”

Section: Hematopoieitic Stem Cellsmentioning

confidence: 99%

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Cord Blood as a Treatment for Stroke

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Factors Influencing the Umbilical Cord Blood Stem Cell Industry: An Evolving Treatment Landscape

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2018

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Hematopoietic stem cell transplantation (HSCT) is common practice today for life threatening malignant and non‐malignant diseases of the blood and immune systems. Umbilical cord blood (UCB) is rich in hematopoietic stem cells (HSCs) and is an attractive alternative to harvesting HSCs from bone marrow or when mobilized into peripheral blood. One of the most appealing attributes of UCB is that it can be banked for future use and hence provides an off‐the‐shelf solution for patients in urgent need of a transplantation. This has led to the establishment of publicly funded and private UCB banks, as seen by the rapid growth of the UCB industry in the early part of this century. However, from about 2010, the release of UCB units for treatment purposes plateaued and started to decrease year‐on‐year from 2013 to 2016. Our interest has been to investigate the factors contributing to these changes. Key drivers influencing the UCB industry include the emergence of haploidentical HSCT and the increasing use of UCB units for regenerative medicine purposes. Further influencing this dynamic is the high cost associated with UCB transplantation, the economic impact of sustaining public bank operations and an active private UCB banking sector. We foresee that these factors will continue in a tug‐of‐war fashion to shape and finally determine the fate of the UCB industry. stem cells translational medicine 2018 Stem Cells Translational Medicine 2018;7:643–650

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Defining umbilical cord blood stem cells

Cited by 20 publications

References 62 publications

Hematological profile including alkali resistant hemoglobin of neonates at birth using cord blood in relation to gestational age and maternal diseases

Hematological profile including alkali resistant hemoglobin of neonates at birth using cord blood in relation to gestational age and maternal diseases

Cord Blood as a Treatment for Stroke

Factors Influencing the Umbilical Cord Blood Stem Cell Industry: An Evolving Treatment Landscape

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