Defining Urticarial Dermatitis

Kossard, Steven; Hamann, Ian; Wilkinson, Brendan L.

doi:10.1001/archderm.142.1.29

Cited by 54 publications

(14 citation statements)

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“…In conclusion, to the best of our knowledge, this is the first prospective study designed to identify the characteristics of itch and therapeutic efficacy of cyclosporine for urticarial dermatitis12. Based on our findings, we recommend a low-dose cyclosporine as a useful treatment option for urticarial dermatitis.…”

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

“…Urticarial dermatitis is a novel clinical and histological term used to describe patients showing a specific, evident dermal hypersensitivity reaction pattern123. In 2006, Kossard et al2 defined urticarial dermatitis as a subset of dermal hypersensitivity reactions with clinically relevant characteristics compared with alternative, differential diagnoses. Skin biopsy is often required to differentiate these disorders and histopathological findings of urticarial dermatitis commonly show minimal epidermal spongiosis and perivascular inflammation of lymphohistiocytes and a few eosinophils, without evidence of vasculitis45.…”

Section: Discussionmentioning

confidence: 99%

“…Urticarial dermatitis was defined by the strict criteria of previously published studies12. Requirements for a diagnosis of urticarial dermatitis included both clinical and histopathologic characteristics which were outlined by Kossard et al2 in 2006. Clinical criteria were both eczematous and urticarial lesions lasting longer than 24 hours.…”

Section: Methodsmentioning

confidence: 99%

“…Up until now, the detrimental effects on the quality of life of subjects with urticarial dermatitis were not well understood and there is no study about the characteristics of itch. Although the optimal treatment for urticarial dermatitis remains to be solved, there have been several reports about various therapeutic trials using topical or systemic steroids, antihistamines, dapsone, mycophenolate mofetil or phototherapy in the literature123. Therefore, this study aimed to investigate the characteristics of itch and to evaluate the therapeutic effects of low-dose cyclosporine for urticarial dermatitis.…”

Section: Introductionmentioning

confidence: 99%

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Urticarial Dermatitis: Clinical Characteristics of Itch and Therapeutic Response to Cyclosporine

et al. 2017

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BackgroundUrticarial dermatitis, which is characterised by persistent wheals with eczematous papules and plaques, is frequently misdiagnosed and difficult to treat. Patients commonly experience intolerable pruritus which may greatly affect their quality of life.ObjectiveThe objective of this study is to characterize the clinical patterns of pruritus in patients with urticarial dermatitis and to determine the effectiveness of cyclosporine treatment.MethodsThis prospective study included 50 histopathologically confirmed patients with urticarial dermatitis. A face-to-face structured questionnaire was given to all patients, and they were treated with low-dose cyclosporine (1~3 mg/kg/d) for at least 2 weeks.ResultsThe majority of patients (80.0%) had moderate to severe pruritus. Most patients experienced exacerbation of the itch in the evening (74.0%), with the extremities (upper, 86.0%; lower, 94.0%) being the most commonly involved sites. Due to severe pruritus, patients complained about reduced social contact, quality of life and difficulties in falling asleep et al. Cyclosporine significantly reduced the mean itch score and extent of erythema, and improved interference with daily activities and sleep.ConclusionOur study highlights the detailed description and characteristics of pruritus in patients with urticarial dermatitis. And we recommend alternative and effective therapeutic option of low-dose cyclosporine.

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Section: Discussionmentioning

confidence: 57%