Definition of chemical markers for Hancornia speciosa Gomes by chemometric analysis based on the chemical composition of extracts, their vasorelaxant effect and α-glucosidase inhibition

Pereira, Ana Bárbara Dias; Gomes, José Hugo de Sousa; Pereira, Aline Carvalho; Pádua, Rodrigo Maia de; Côrtes, Steyner F.; Sena, Marcelo M.; Braga, Fernão Castro

doi:10.1016/j.jep.2022.115692

Cited by 2 publications

(1 citation statement)

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“…The extracts had their anti-oxidant activity assayed in vitro, along with their effect on the release of TNF by LPS-stimulated THP-1 cells, to access their potential anti-inflammatory effect. Finally, a multi-variate exploratory principal component analysis (PCA) model [15,16] was built, aiming to investigate the possible existence of correlations between the quantitative chemical composition of the extracts and their biological effects.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Chemical Composition, Anti-Oxidant Activity, and Inhibition of TNF Release by THP-1 Cells Induced by Extracts of Echinodorus macrophyllus and Echinodorus grandiflorus

Rocha

Gomes

et al. 2023

Antioxidants

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This study investigated the similarities between Echinodorus macrophyllus and Echinodorus grandiflorus, plant species that are traditionally used in Brazil to treat rheumatism and arthritis, whose anti-inflammatory effects are supported by scientific evidence. The contents of cis- and trans-aconitic acid, homoorientin, chicoric acid, swertisin, caffeoyl-feruloyl-tartaric acid, and di-feruloyl-tartaric acid were quantified by UPLC-DAD in various hydroethanolic extracts from the leaves, whereas their anti-oxidant activity and their effect on TNF release by LPS-stimulated THP-1 cells were assessed to evaluate potential anti-inflammatory effects. The 50% and 70% ethanol extracts showed higher concentrations of the analyzed markers in two commercial samples and a cultivated specimen of E. macrophyllus, as well as in a commercial lot of E. grandiflorus. However, distinguishing between the species based on marker concentrations was not feasible. The 50% and 70% ethanol extracts also exhibited higher biological activity, yet they did not allow differentiation between the species, indicating similar chemical composition and biological effects. Principal component analysis highlighted comparable chemical composition and biological activity among the commercial samples of E. macrophyllus, while successfully distinguishing the cultivated specimen from the commercial lots. In summary, no differences were observed between the two species in terms of the evaluated chemical markers and biological activities.

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Section: Introductionmentioning

confidence: 99%