Definition of Epigenetic Transgenerational Inheritance and Biological Impacts

Nilsson, Eric; Skinner, Michael K.

doi:10.1016/b978-0-12-405944-3.00002-7

Cited by 9 publications

(7 citation statements)

References 48 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study of epigenetics, especially DNAm, has highlighted the possibility that some of the effects of experienced trauma on subsequent generations may occur via both behavioral and biological transmission (Jawaid et al., 2018; Kaati et al., 2007; Perez & Lehner, 2019; Roberts et al., 2018; Yehuda et al., 2014; Youssef et al., 2018), though the mechanism of biological transmission is controversial and debated within the field (Krippner & Deirdre, 2019; Nilsson et al., 2019; Otterdijk & Michels, 2016). Here, we examine in humans the associations between fathers’ exposure to adverse childhood experiences (ACEs) and DNAm in their 3‐month‐old offspring to test the possible connection between paternal early experiences of adversity and a biological marker of these experiences in their children.…”

Section: Introductionmentioning

confidence: 99%

Paternal adverse childhood experiences: Associations with infant DNA methylation

Merrill

Moore

Gladish

et al. 2021

Developmental Psychobiology

View full text Add to dashboard Cite

Adverse childhood experiences (ACEs), or cumulative childhood stress exposures, such as abuse, neglect, and household dysfunction, predict later health problems in both the exposed individuals and their offspring. One potential explanation suggests exposure to early adversity predicts epigenetic modification, especially DNA methylation (DNAm), linked to later health. Stress experienced preconception by mothers may associate with DNAm in the next generation. We hypothesized that fathers’ exposure to ACEs also associates with their offspring DNAm, which, to our knowledge, has not been previously explored. An epigenome‐wide association study (EWAS) of blood DNAm (n = 45) from 3‐month‐old infants was regressed onto fathers’ retrospective ACEs at multiple Cytosine‐phosphate‐Guanosine (CpG) sites to discover associations. This accounted for infants’ sex, age, ethnicity, cell type proportion, and genetic variability. Higher ACE scores associated with methylation values at eight CpGs. Post‐hoc analysis found no contribution of paternal education, income, marital status, and parental postpartum depression, but did with paternal smoking and BMI along with infant sleep latency. These same CpGs also contributed to the association between paternal ACEs and offspring attention problems at 3 years. Collectively, these findings suggested there were biological associations with paternal early life adversity and offspring DNAm in infancy, potentially affecting offspring later childhood outcomes.

show abstract

Section: Introductionmentioning

confidence: 99%

Paternal adverse childhood experiences: Associations with infant DNA methylation

Merrill

Moore

Gladish

et al. 2021

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…Several reports mention that sperm carries non-genomic factors, such as small noncoding RNA (sncRNA) and epigenetic modifications, that are sensitive to diet [11,12]. Therefore, the phenotypes observed in the sons of HFD mice are likely manifestations of intergenerational effects of HFD, i.e., they are the result of direct exposure of the male gamete to the toxicant (HFD) [13].…”

Section: Discussionmentioning

confidence: 99%

High-Fat Diet Promotes a Pro-Inflammatory Environment in Testis and Inhibits Antioxidant Defenses in the Progeny

Crisóstomo

Videira

Jarak

et al. 2020

The 1st International E-Conference on Antioxidants in Health and Disease

View full text Add to dashboard Cite

The adoption of high-fat diets (HFDs) is a major contributor to the increasing prevalence of obesity worldwide. Herein, we study the impact of an HFD from early age in testicular physiology and sperm parameters in two generations of mice, with a focus on testicular oxidative status. Mice of the diet-challenged generation (F0; n = 36) were randomly fed after weaning with standard chow (CTRL), a high-fat diet (HFD) for 200 days, or a transient high-fat diet (HFDt) (60 days of HFD + 140 days of standard chow). The offspring generation (F1; n = 36) was obtained by mating normoponderal females with those fed a chow diet 120 days post-weaning. Mice fed an HFD for a lifetime presented impaired insulin tolerance, a trait inherited by their sons. The sons of mice fed HFD inherited decreased catalase activity and displayed lower activities of mitochondrial complexes I and IV. Similar to their progenitors, the sons of HFD mice had a higher prevalence of pinhead and bent neck defects than that of the sons of the CTRL mice. The adoption of HFD impaired testicular antioxidant defenses and mitochondrial function in the progeny, which is detrimental to sperm morphology.

show abstract

“…Emerging research in epigenetics suggests that a range of environmental factors, lifestyle, early life stress, and trauma can influence the establishment and maintenance of epigenetic marks through generations (often known as epigenetic memory) [11,16,17]. Epigenetic reprogramming of induced pluripotent stem cells to develop novel treatments for diseases is an emerging area of research [18].…”

Section: Epigeneticsmentioning

confidence: 99%

Histone acetylation and the role of histone deacetylases in normal cyclic endometrium

Gujral

Mahajan

Lissaman

et al. 2020

Reprod Biol Endocrinol

115

View full text Add to dashboard Cite

Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the chromatin structure. It plays an essential role in cell cycle progression and differentiation. The human endometrium goes through cycles of regeneration, proliferation, differentiation, and degradation each month; each phase requiring strict epigenetic regulation for the proper functioning of the endometrium. Aberrant histone acetylation and alterations in levels of two acetylation modulators-histone acetylases (HATs) and histone deacetylases (HDACs)-have been associated with endometrial pathologies such as endometrial cancer, implantation failures, and endometriosis. Thus, histone acetylation is likely to have an essential role in the regulation of endometrial remodelling throughout the menstrual cycle.

show abstract

Definition of Epigenetic Transgenerational Inheritance and Biological Impacts

Cited by 9 publications

References 48 publications

Paternal adverse childhood experiences: Associations with infant DNA methylation

Paternal adverse childhood experiences: Associations with infant DNA methylation

High-Fat Diet Promotes a Pro-Inflammatory Environment in Testis and Inhibits Antioxidant Defenses in the Progeny

Histone acetylation and the role of histone deacetylases in normal cyclic endometrium

Contact Info

Product

Resources

About