Deformation and fragmentation of human red blood cells in turbulent shear flow

Sutera, Salvatore P.; Mehrjardi, M

doi:10.1016/s0006-3495(75)85787-0

Cited by 194 publications

(137 citation statements)

References 7 publications

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“…Blood trauma can occur via several mechanisms, depending on the type of damaged blood cell. In the past, the fragmentation and damaging of erythrocytes was experimentally quantified, since this leads to hemolysis (Sutera et al, 1975;Paul et al, 2003). In recent years, however, platelet activation is believed to be the major underlying formation mechanism for thromboembolic complications in the flow past mechanical heart valves (Bluestein, 2004;Morbiducci et al, 2009).…”

Section: Blood Damage and Bmhvsmentioning

confidence: 99%

State-Of-The-Art Methods for the Numerical Simulation of Aortic BMHVs

Annerel¹,

Claessens²,

Ransbeeck³

et al. 2011

Aortic Valve

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Section: Blood Damage and Bmhvsmentioning

confidence: 99%

State-Of-The-Art Methods for the Numerical Simulation of Aortic BMHVs

Annerel¹,

Claessens²,

Ransbeeck³

et al. 2011

Aortic Valve

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“…Hemolysis can occur in three ways: by natural selection of the spleen, physico-chemical imbalance (usually pathological), or by exposing the cells to a nonphysiological mechanical stress [2].…”

Section: Introductionmentioning

confidence: 99%

“…The hemolytic aspects have been studied by several researchers in an attempt to isolate and understand the factors causing hemolysis [2][3][4][5]. Experimentally, the red blood cells can be damaged during the flow of two factors acting simultaneously: the level of shear stress and exposure time of the cell to such stress [2,6,7].…”

Section: Introductionmentioning

confidence: 99%

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Hemolysis in extracorporeal circulation: relationship between time and procedures

Junior¹,

Antunes²,

Vieira³

et al. 2012

Revista Brasileira De Cirurgia Cardiovascular

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Introduction: Extracorporeal circulation (EC) is very important in cardiac surgery but causes significant damage to the blood, including hemolysis.Objective: To quantify the rate of hemolysis at different times during EC in elective coronary artery bypass grafting.Methods: We measured rates of hemolysis of 22 patients at 6 different times during myocardial revascularization during EC: T0 -before the start of EC, T1 -five minutes after of the EC initiation, T2 -30 minutes of EC, T3 -immediately before the aortic unclamping, T4 -immediately before passage of the residual volume to the patient and T5 -five minutes after the passage of the residual volume to the patient. Rates of hemolysis were calculated between the intervals of time: T0-T1; T1-T2; T2-T3; T3-T4 and T4-T5.Results: The first 5 minutes after the EC showed the highest rate of hemolysis (P = 0.0003) compared to the others calculated rates, representing 29% of the total haemolysis until T4 (Immediately before passage of the residual volume to the patient).Conclusion: There were no significant changes in the rate of hemolysis during the suction in the aortic root (P > 0.38), nor with the procedure used for the passage of the residual volume of blood in the circuit to the patient.Keywords: Extracorporeal circulation. Hemolysis. Blood. ResumoIntrodução: A circulação extracorpórea (CEC) é indispensável para a maioria das operações cardíacas, mas causa danos significantes ao sangue, dentre eles a hemólise.Objetivo: Quantificar as taxas de hemólise em diferentes tempos nas operações para revascularização do miocárdio com uso de CEC. 536Rev Bras Cir Cardiovasc 2012;27(4) Resultados: Os primeiros 5 minutos após a CEC demonstraram maior taxa de hemólise (P = 0,0003) em comparação às outras taxas calculadas, representando 29% da hemólise total até T4 (imediatamente antes da passagem do volume residual para o paciente).Conclusão: Não foram observadas variações significantes nas taxas de hemólise durante a aspiração na raiz da aorta (P > 0,38) nem com o procedimento utilizado para a passagem do volume residual de sangue no circuito para os pacientes.

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“…Fluid mechanical forces can affect hemolysis, platelet activation and aggregation, as well as myocardial remodeling (2,(5)(6)(7)(8)(9). In both normal and diseased hearts, blood flows in a highly complex manner though the cardiac chambers.…”

Section: Introductionmentioning

confidence: 99%

Flow Imaging: Cardiac Applications of 3D Cine Phase-Contrast MRI

Ebbers

2011

Curr Cardiovasc Imaging Rep

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Global and regional blood flow dynamics are of pivotal importance to cardiac function. Fluid mechanical forces can affect hemolysis and platelet aggregation, as well as myocardial remodeling. In recent years, assessment of blood flow patterns based on time-resolved, three-dimensional, three-directional phasecontrast magnetic resonance imaging (3D cine PC MRI)(1) has become possible and rapidly gained popularity. Initially, this technique was mainly known for its intuitive and appealing visualizations of the cardiovascular blood flow. Most recently, the technique has begun to go beyond compelling images towards comprehensive and quantitative assessment of blood flow. In this article, cardiac applications of 3D cine PC MRI data are discussed, starting with a review of the acquisition and analysis techniques, and including descriptions of promising applications of cardiac 3D cine PC MRI for the clinical evaluation of myocardial, valvular and vascular disorders.3

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Deformation and fragmentation of human red blood cells in turbulent shear flow

Cited by 194 publications

References 7 publications

State-Of-The-Art Methods for the Numerical Simulation of Aortic BMHVs

State-Of-The-Art Methods for the Numerical Simulation of Aortic BMHVs

Hemolysis in extracorporeal circulation: relationship between time and procedures

Flow Imaging: Cardiac Applications of 3D Cine Phase-Contrast MRI

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