Over the [Formula: see text]-dimensional real superspace, we compute the cohomology space of the affine Lie superalgebra [Formula: see text] with coefficient in a large class of [Formula: see text]-modules [Formula: see text]. We apply our results to the module [Formula: see text] of weight densities and the module [Formula: see text] of linear differential operators acting on a superspace of weighted densities. We study nontrivial deformations of the natural action of the Lie superalgebra [Formula: see text] on the direct sum of the superspaces of weighted densities.