Degeneración de los terminales aferentes primarios de rata luego de lesión extensa por avulsión del plexo braquial

Muñetón-Gómez, Vilma C.; Taylor, Julian; Averill, Sharon; Priestley, John V.; Nieto–Sampedro, Manuel

doi:10.7705/biomedica.v24i2.1264

Cited by 13 publications

(1 citation statement)

References 56 publications

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“…Most of somatic and autonomic nerve endings in tissues (Peripheral Nervous System) are communicated with ganglia, which are groups of neurons outside the CNS. Their axons communicate at various metameric levels with the spinal cord [12,13] reaching the brain in an organized or somatotopic manner. ACE-2 receptor is expressed in the spinal cord and angiotensin, a neuropeptide involved in nociception [14].…”

Section: Spinal Cord Infectionmentioning

confidence: 99%

Virus Sars-CoV-2 as a Neuroinvasive Agent

Gómez¹

2021

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The nervous system is involved in different vital functions that guarantee the survival of the individual. Covid-19 infection is a multisystemic and multi organic disease that disrupts homeostasis and endangers the infected individual's life. It leads to neurological manifestations of varying intensity. However, the nervous system as a target of CoV-2 virus infection must be clarified. In this review we examine the expression of ACE-2 receptor and the interaction of Co-2 virus with nerve cells, describing some findings in nerve cells of different organs. Additionally, a CoV-2 dissemination map is postulated, with emphasis on the nervous functions at the somatic and autonomic levels.

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Section: Spinal Cord Infectionmentioning

confidence: 99%

Virus Sars-CoV-2 as a Neuroinvasive Agent

Gómez¹

2021

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Identification of perineal sensory neurons activated by innocuous heat

Kiasalari

Salehi

Zhong

et al. 2009

J of Comparative Neurology

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C-fiber sensory neurons comprise nociceptors and smaller populations of cells detecting innocuous thermal and light tactile stimuli. Markers identify subpopulations of these cells, aiding our understanding of their physiological roles. The transient receptor potential vanilloid 1 (TRPV1) cation channel is characteristic of polymodal C-fiber nociceptors and is sensitive to noxious heat, irritant vanilloids, and protons. By using immunohistochemistry, in situ hybridization, and retrograde tracing, we anatomically characterize a small subpopulation of C-fiber cells that express high levels of TRPV1 (HE TRPV1 cells). These cells do not express molecular markers normally associated with C-fiber nociceptors. Furthermore, they express a unique complement of neurotrophic factor receptors, namely, the trkC receptor for neurotrophin 3, as well as receptors for neurturin and glial cell line-derived neurotrophic factor. HE TRPV1 cells are distributed in sensory ganglia throughout the neuraxis, with higher numbers noted in the sixth lumbar ganglion. In this ganglion and others of the lumbar and sacral regions, 75% or more of such HE TRPV1 cells express estrogen receptor alpha, suggestive of their regulation by estrogen and a role in afferent sensation related to reproduction. Afferents from these cells provide innervation to the hairy skin of the perineal region and can be activated by thermal stimuli from 38 degrees C, with a maximal response at 42 degrees C, as indicated by induction of extracellular signal-regulated kinase phosphorylation. We hypothesize that apart from participating in normal thermal sensation relevant to thermoregulation and reproductive functions, HE TRPV1 cells may mediate burning pain in chronic pain syndromes with perineal localization.

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The possible role of regenerating axons in pain persistence after brachial plexus grafting

Bertelli

Ghizoni

2010

Microsurgery

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We tested the hypothesis that chronic pain in patients with grafted brachial plexus injuries stems from regenerating axons. Eight patients who had undergone brachial plexus grafting still reported persistent pain 24 months after surgery, and were followed for an additional 6 months. After recording each patient's self-reported pain severity using a 10-point verbal analogue scale, a tourniquet was inflated in the injured arm for 90 seconds. Then, patients were asked again to rate their pain. Finally, anesthetic blocks were administered to the nonavulsed C5 root. After tourniquet application to the injured limb, pain significantly decreased by 85% (P < 0.001) in all grafted patients. Anesthetic blocks yielded at least 90% pain reduction. Our findings suggest that pain after brachial plexus injury arises from nonavulsed rather than avulsed roots. After grafting, regenerating axons which have attained the periphery might be responsible for pain maintenance.

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Degeneración de los terminales aferentes primarios de rata luego de lesión extensa por avulsión del plexo braquial

Cited by 13 publications

References 56 publications

Virus Sars-CoV-2 as a Neuroinvasive Agent

Virus Sars-CoV-2 as a Neuroinvasive Agent

Identification of perineal sensory neurons activated by innocuous heat

The possible role of regenerating axons in pain persistence after brachial plexus grafting

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