Despite rapid recent progress towards the development of quantum computers capable of providing computational advantages over classical computers, it seems likely that such computers will, initially at least, be required to run in a hybrid quantum-classical regime. This realisation has led to interest in hybrid quantum-classical algorithms allowing, for example, quantum computers to solve large problems despite having very limited numbers of qubits. Here we propose a hybrid paradigm for quantum annealers with the goal of mitigating a different limitation of such devices: the need to embed problem instances within the (often highly restricted) connectivity graph of the annealer. This embedding process can be costly to perform and may destroy any computational speedup. In order to solve many practical problems, it is moreover necessary to perform many, often related, such embeddings. We will show how, for such problems, a raw speedup that is negated by the embedding time can nonetheless be exploited to give a real speedup. As a proof-of-concept example we present an in-depth case study of a simple problem based on the maximum weight independent set problem. Although we do not observe a quantum speedup experimentally, the advantage of the hybrid approach is robustly verified, showing how a potential quantum speedup may be exploited and encouraging further efforts to apply the approach to problems of more practical interest.Quantum computation has the potential to revolutionise computer science, and as a consequence has, since its inception, received a great deal of attention from theorists and experimentalists alike. Although much progress has been made through the concerted efforts of the community, we are still some distance from being able to build sufficiently large-scale universal quantum computers to realise this potential [1,2].More recently, however, significant progress has been made in the development of special-purpose quantum computers. This has been driven by the realisation that, by dropping the requirement of being able to efficiently simulate arbitrary computations and relaxing some of the constraints that make large-scale universal quantum computing difficult (e.g., the ability to apply gates to arbitrary pairs of, possibly non-adjacent, qubits), such devices can be more easily engineered and scaled. The expectation is that with this approach one may be able to exploit some of the capabilities of quantum computation-even if its full abilities are for now beyond our reach-to obtain lesser, but nevertheless practical, advantages in practical applications. Quantum annealers, which solve particular optimisation problems, exemplify this approach, and significant progress has been made in recent years towards engineering moderately large-scale such devices [3,4]. This approach has been pursued particularly zealously by D-Wave, who have developed quantum annealers with upwards of 2000 qubits (e.g., the D-Wave 2000Q™ machine [5]), and are thus of sufficient size to tackle problems for which their performanc...