Degenerative mineralization in the fibrous capsule of silicone breast implants

Legrand, A.P.; Маринов, Г.; Pavlov, Stoyan; Guidoin, Marie-France; Famery, Roger; Bresson, Bruno; Zhang, Ze; Guidoin, Robert

doi:10.1007/s10856-005-6989-0

Cited by 22 publications

(21 citation statements)

References 20 publications

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“…Furthermore, macrophages and foreign body giant cells recruit fibroblasts which direct the fibrous encapsulation of the implant [2]. This foreign body response limits the functional performance of numerous implanted biomaterial such as pacemaker leads [4], glucose sensors [5], sensor electrodes [6], drug delivery devices [7] and breast implants [8]. Macrophages also play a major role in the body's response to particulate materials.…”

Section: Introductionmentioning

confidence: 99%

Integrin-directed modulation of macrophage responses to biomaterials

et al. 2014

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Macrophages are the primary mediator of chronic inflammatory responses to implanted biomaterials, in cases when the material is either in particulate or bulk form. Chronic inflammation limits the performance and functional life of numerous implanted medical devices, and modulating macrophage interactions with biomaterials to mitigate this response would be beneficial. The integrin family of cell surface receptors mediates cell adhesion through binding to adhesive proteins nonspecifically adsorbed onto biomaterial surfaces. In this work, the roles of integrin Mac-1 (αMβ2) and RGD-binding integrins were investigated using model systems for both particulate and bulk biomaterials. Specifically, the macrophage functions of phagocytosis and inflammatory cytokine secretion in response to a model particulate material, polystyrene microparticles were investigated. Opsonizing proteins modulated microparticle uptake, and integrin Mac-1 and RGD-binding integrins were found to control microparticle uptake in an opsonin-dependent manner. The presence of adsorbed endotoxin did not affect microparticle uptake levels, but was required for the production of inflammatory cytokines in response to microparticles. Furthermore, it was demonstrated that integrin Mac-1 and RGD-binding integrins influence the in vivo foreign body response to a bulk biomaterial, subcutaneously implanted polyethylene terephthalate. A thinner foreign body capsule was formed when integrin Mac-1 was absent (~30% thinner) or when RGD-binding integrins were blocked by controlled release of a blocking peptide (~45% thinner). These findings indicate integrin Mac-1 and RGD-binding integrins are involved and may serve as therapeutic targets to mitigate macrophage inflammatory responses to both particulate and bulk biomaterials.

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Section: Introductionmentioning

confidence: 99%

Integrin-directed modulation of macrophage responses to biomaterials

et al. 2014

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“…The most common sign or symptom of PAAG injection is the development of breast lumps, which are concerning to the patient and provider as they may simulate malignancy [9]. There is a tendency for PAAG to form globules, which may present as a palpable mass on physical examination and be A B seen on imaging as a discrete mass [10]. In a study of patients undergoing surgery following PAAG augmentation, breast pain was the most common indication for surgery, followed by breast hardening and breast deformity [2].…”

Section: Discussionmentioning

confidence: 99%

Polyacrylamide gel breast augmentation: report of two cases and review of the literature

Margolis¹,

Bassiri-Tehrani²,

Chhor³

et al. 2015

Clinical Imaging

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“…However, there are still many tribulations when using this material. The intrinsically hydrophobic nature of SR surface makes cell adhesion almost impossible, causing problems like fibrous capsules, contracture formation, and displacement during long-term usage [4]–[6]. Poor cell adhesion on its surface allows a gap to form between the SR implant and surrounding tissues, this can lead to bacterial invasion [7].…”

Section: Introductionmentioning

confidence: 99%

Osteopontin (OPN) Is an Important Protein to Mediate Improvements in the Biocompatibility of C Ion-Implanted Silicone Rubber

et al. 2014

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Medical device implants are drawing increasing amounts of interest from modern medical practitioners. However, this attention is not evenly spread across all such devices; most of these implantable devices can cause adverse reactions such as inflammation, fibrosis, thrombosis, and infection. In this work, the biocompatibility of silicone rubber (SR) was improved through carbon (C) ion implantation. Scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD) results confirmed that these newly generated carbon-implanted silicone rubbers (C-SRs) had large, irregular peaks and deep valleys on their surfaces. The water contact angle of the SR surface decreased significantly after C ion implantation. C ion implantation also changed the surface charge distribution, silicone oxygen rate, and chemical-element distribution of SR to favor cell attachment. The dermal fibroblasts cultured on the surface C-SR grew faster and showed more typical fibroblastic shapes. The expression levels of major adhesion proteins, including talin-1, zyxin, and vinculin, were significantly higher in dermal fibroblasts cultured on C-SR coated plates than in dermal fibroblasts cultured on SR. Those same dermal fibroblasts on C-SRs showed more pronounced adhesion and migration abilities. Osteopontin (OPN), a critical extracellular matrix (ECM) protein, was up-regulated and secreted from dermal fibroblasts cultured on C-SR. Matrix metalloproteinase-9 (MMP-9) activity was also increased. These cells were highly mobile and were able to adhere to surfaces, but these abilities were inhibited by the monoclonal antibody against OPN, or by shRNA-mediated MMP-9 knockdown. Together, these results suggest that C ion implantation significantly improves SR biocompatibility, and that OPN is important to promote cell adhesion to the C-SR surface.

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Degenerative mineralization in the fibrous capsule of silicone breast implants

Cited by 22 publications

References 20 publications

Integrin-directed modulation of macrophage responses to biomaterials

Integrin-directed modulation of macrophage responses to biomaterials

Polyacrylamide gel breast augmentation: report of two cases and review of the literature

Osteopontin (OPN) Is an Important Protein to Mediate Improvements in the Biocompatibility of C Ion-Implanted Silicone Rubber

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