Degenerative Osteoarthrosis in Aged ICR Mice

Abstract

The tibia of 117 aged ICR mice was examined histologically to provide further information on degenerative osteoarthrosis.Incidence of the lesion became higher in the male older than 480 days of age and in the female older than 450 days. Main gross changes were roughening of the articular surface, narrowing or focal thickening of the articular cartilage, and osteophytes at the margins of the joint. Histology revealed loosening of the matrix, erosion, and marginal osteophytes in the articular cartilage, and sclerotic changes of the subchondral bone.

Lifelong moderate running training increases the incidence and severity of osteoarthritis in the knee joint of C57BL mice

“…The aggressive behavior, fighting, and trauma of the DBN1 male mice Nordling et al, 19921, hypopituitarism and somatotrophin deficiency of the dwarf mice (Silberberg, 19721, and the defect of lysyl oxidase -enzyme in collagen cross-linking of the Blotchy mice (Silberberg, 1977) increase the incidence of osteoarthritis. High incidences have also been observed in NZY/Bl mice (Wigley et al, 1977) and ICR mice (Yamasaki, 1986). Alterations of the genes for the type I1 collagen produce arthropathies that closely resemble the primary osteoarthritis in the transgenic mice Metsaranta, 1994).…”