1990
DOI: 10.1159/000100226
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Degenerative Ultrastructural Changes Observed in the Neuropil of Caudate Nuclei from Parkinson's Disease Patients

Abstract: Degenerative changes of the pars compacta of the substantia nigra are considered the main physiopathological basis of Parkinson''s disease, while most authors believe that the neostriatum is well preserved in these cases. This paper deals with the preliminary ultrastructural observations made in the neuropil of the caudate nucleus of Parkinson''s disease patients. We have observed (1) astrocytic proliferation, neuronal degeneration, degenerated axons, and hyperdense postsynaptic neurites (dendrites), and (2) t… Show more

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Cited by 5 publications
(2 citation statements)
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“…Concerning dendritic spine loss, Roberts and DiFiglia [78], Ingham et al [68], Pickel et al [69], Stephens et al [79], and Avila-Costa et al [33, 70] found that the proportion of axospinous synapses was significantly reduced in the ipsilateral striatum of the 6-OHDA lesioned rats, type of synapse that also decrease in caudate nucleus of PD patients [80–82]. Here we found an evident loss of dendritic spines in 6OHDA-lesioned and LD-treated rats.…”
Section: Discussionmentioning
confidence: 99%
“…Concerning dendritic spine loss, Roberts and DiFiglia [78], Ingham et al [68], Pickel et al [69], Stephens et al [79], and Avila-Costa et al [33, 70] found that the proportion of axospinous synapses was significantly reduced in the ipsilateral striatum of the 6-OHDA lesioned rats, type of synapse that also decrease in caudate nucleus of PD patients [80–82]. Here we found an evident loss of dendritic spines in 6OHDA-lesioned and LD-treated rats.…”
Section: Discussionmentioning
confidence: 99%
“…Alzheimer disease brains exhibit decreased synaptic density (Masliah et al , 2001), even in the earliest stages of clinical disease (Scheff et al , 2006), and inhibition of hippocampal long-term potentiation has been demonstrated in animal models (Chapman et al 1999; LaFerla & Oddo 2005; Walsh et al 2002). Alterations in synaptic morphology are also observed in the basal ganglia of Parkinson’s disease patients (Lach et al , 1992; Machado-Salas et al , 1990), with synaptic dysfunction as a prominent feature in models based on mutations in α- synuclein [Reviewed in (Cookson and van der Brug, 2008)] or PINK1 (Kitada et al , 2007). In models of Huntington disease, the medium spiny striatal neurons demonstrate abnormal dendritic spine morphology and electrophysiology (Di Filippo et al , 2007).…”
Section: Introductionmentioning
confidence: 99%