Degradable and Resorbable Biomaterials

Treiser, Matthew D.; Abramson, Sascha; Langer, Robert; Kohn, Joachim

doi:10.1016/b978-0-08-087780-8.00021-8

Cited by 44 publications

(51 citation statements)

References 72 publications

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“…Varying the lactide:glycolide ratio in the copolymer or the D:L ratio in the lactide monomer tunes strength, hydrophilicity, and degradation rate. (56) The fast degradation of PGA/PLGA and the slow of PLA make them useful for extreme degradation rate strategies. The materials are clinically accepted as resorbable sutures and orthopedic implants.…”

Section: Designs and Progressmentioning

confidence: 99%

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Quickening: Translational design of resorbable synthetic vascular grafts

Stowell

Wang

2018

Biomaterials

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Traditional tissue-engineered vascular grafts have yet to gain wide clinical use. The difficulty of scaling production of these cell- or biologic-based products has hindered commercialization. In situ tissue engineering bypasses such logistical challenges by using acellular resorbable scaffolds. Upon implant, the scaffolds become remodeled by host cells. This review describes the scientific and translational advantages of acellular, synthetic vascular grafts. It surveys in vivo results obtained with acellular synthetics over their fifty years of technological development. Finally, it discusses emerging principles, highlights strategic considerations for designers, and identifies questions needing additional research.

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Section: Designs and Progressmentioning

confidence: 99%

“…The materials are clinically accepted as resorbable sutures and orthopedic implants. (56,57) Concerns with this polymer family include their acidic degradation products, moderate cytocompatibility, and supraphysiologic stiffness.…”

Section: Designs and Progressmentioning

confidence: 99%

Quickening: Translational design of resorbable synthetic vascular grafts

Stowell

Wang

2018

Biomaterials

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“…Hydrolysis is the most common chemical process by which polymers degrade but degradation can also occur via oxidative, photodegradative, and enzymatic mechanisms [10]. All polymers undergo some degree of degradation.…”

Section: Mechanisms Of Degradation and In Vitro Testing Of Biomateriamentioning

confidence: 99%

“…However, in most cases, no attempts have been made to develop these new materials for specific medical applications. In addition, only a small fraction of these polymers have been studied in terms of their in vivo toxicological profiles, degradation rates and mechanisms, and their physicomechanical properties [10]. An even smaller number of synthetic, degradable polymers have been used in medical implants and devices that have gained approval by the United States Food and Drug Administration (FDA) for use in patients.…”

Section: Introductionmentioning

confidence: 99%

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Biodegradable Airway Stents - Bench to Bedside: A Comprehensive Review

Dutau¹,

Musani

Laroumagne³

et al. 2015

Respiration

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Airway stents are indicated to treat symptomatic narrowing or to close fistulas of the central airways. They are generally divided into two types: the silicone stents and the metallic stents. Unlike in malignancies, removability is a major objective of temporary stenting in benign conditions, which poses the challenge of a new rigid bronchoscopic procedure under general anesthesia and stent removal with all its attendant risks and costs. The concept of a biodegradable (BD) stent that could maintain the patency of an airway for a predetermined duration of time is very appealing. These BD stents would gradually degrade and eventually vanish from the airway once they are no longer needed. Such stents are currently an area of intense research. Another very promising concept of drug delivery with such stents is also a very exciting area of current research. The aim of this comprehensive review is to discuss all pertinent available literature on the use of BD materials in various clinical applications and to extensively review all animal and humans trials involving BD airway stents.

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