Degradation and transformation of fluoroquinolones by microorganisms with special emphasis on ciprofloxacin

Rusch, Marina; Spielmeyer, Astrid; Zorn, Holger; Hamscher, Gerd

doi:10.1007/s00253-019-10017-8

Cited by 82 publications

(45 citation statements)

References 120 publications

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“…Non-biotic degradation can also take place via hydrolysis, oxidation, reduction, or photolysis, and this also depends on many physicochemical properties and environmental conditions. Residues of synthetic and semi-synthetic antibiotics, such as fluoroquinolones and sulfonamides, are more chemically stable and less susceptible to bacterial degradation processes; thus, their residues are often detected in the environment [18][19][20][21]. A cluster of 90 pharmaceutical factories in India releases wastewater with a content of about 30 mg/L of ciprofloxacin, resulting in the deposition of several kilograms into the environment each day and hence many tons a year; consequently, the waters of the lake near the factories have been found to demonstrate a ciprofloxacin concentration as high as 6.5 mg/L [22].…”

Section: The Fate Of Antibiotics In the Environment And Their Biologimentioning

confidence: 99%

Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Serwecińska

2020

Water

496

206

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The release of antibiotics to the environment, and the consequences of the presence of persistent antimicrobial residues in ecosystems, have been the subject of numerous studies in all parts of the world. The overuse and misuse of antibiotics is a common global phenomenon, which substantially increases the levels of antibiotics in the environment and the rates of their spread. Today, it can be said with certainty that the mass production and use of antibiotics for purposes other than medical treatment has an impact on both the environment and human health. This review aims to track the pathways of the environmental distribution of antimicrobials and identify the biological effects of their subinhibitory concentration in different environmental compartments; it also assesses the associated public health risk and government policy interventions needed to ensure the effectiveness of existing antimicrobials. The recent surge in interest in this issue has been driven by the dramatic increase in the number of infections caused by drug-resistant bacteria worldwide. Our study is in line with the global One Health approach.

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Section: The Fate Of Antibiotics In the Environment And Their Biologimentioning

confidence: 99%

Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Serwecińska

2020

Water

496

206

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“…FQs are recalcitrant to biodegradation in water but are prone to adsorb into sediments in aquatic environments or sludge in WWTPs ( Rusch et al, 2019 ). Owing to the negative effects of FQs and their transformation products (TPs) in the environment, the biodegradation of FQs by microorganisms, such as fungi and bacteria, has been widely studied ( Brienza et al, 2020 ;Rusch et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Biotransformation of lincomycin and fluoroquinolone antibiotics by the ammonia oxidizers AOA, AOB and comammox: A comparison of removal, pathways, and mechanisms

et al. 2021

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In this study, we evaluated the biotransformation mechanisms of lincomycin (LIN) and three fluoroquinolone antibiotics (FQs), ciprofloxacin (CFX), norfloxacin (NFX), and ofloxacin (OFX), which regularly enter aquatic environments through human activities, by different ammonia-oxidizing microorganisms (AOM). The organisms included a pure culture of the complete ammonia oxidizer (comammox) Nitrospira inopinata , an ammonia oxidizing archaeon (AOA) Nitrososphaera gargensis , and an ammonia-oxidizing bacterium (AOB) Nitrosomonas nitrosa Nm90. The removal of these antibiotics by the pure microbial cultures and the protein-normalized biotransformation rate constants indicated that LIN was significantly co-metabolically biotransformed by AOA and comammox, but not by AOB. CFX and NFX were significantly co-metabolized by AOA and AOB, but not by comammox. None of the tested cultures transformed OFX effectively. Generally, AOA showed the best biotransformation capability for LIN and FQs, followed by comammox and AOB. The transformation products and their related biotransformation mechanisms were also elucidated. i) The AOA performed hydroxylation, S-oxidation, and demethylation of LIN, as well as nitrosation and cleavage of the piperazine moiety of CFX and NFX; ii) the AOB utilized nitrosation to biotransform CFX and NFX; and iii) the comammox carried out hydroxylation, demethylation, and demethylthioation of LIN. Hydroxylamine, an intermediate of ammonia oxidation, chemically reacted with LIN and the selected FQs, with removals exceeding 90%. Collectively, these findings provide important fundamental insights into the roles of different ammonia oxidizers and their intermediates on LIN and FQ biotransformation in nitrifying environments including wastewater treatment systems.

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“…Fluoroquinolones tend to be more stable and quickly accumulate in water–sediment systems, such as lakes and rivers (Bairros et al., 2018). They are hard to degrade and are easily transported, leading to a large amount in aquatic ecosystems (Rusch, Spielmeyer, Zorn, & Hamscher, 2019). Thus, the treated wastewater could have been a minor source of residual antibiotics in the three rivers.…”

Section: Resultsmentioning

confidence: 99%

Co‐occurrence characteristics of antibiotics and estrogens and their relationships in a lake system affected by wastewater

2020

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Antibiotics and estrogens are recognized as emerging contaminants in the water environment because of their potentially adverse effects on aquatic ecosystems. The concentrations of four steroid estrogens (17α-estradiol, 17βestradiol, estrone, and estriol) and eight antibiotics (norfloxacin, levofloxacin, ciprofloxacin, enrofloxacin, metronidazole, sulfapyridine, doxycycline, and sulfamethoxazole) in the Chaohu Lake basin in Anhui province, China, were analyzed along with adjacent wastewater. The levels of the target antibiotics and estrogens were below detection limits (not detected [nd])-89.86 and nd-118.09 ng L −1 , respectively, in the lake water. All of the target antibiotics and estrogens were detected in sediment, and the concentrations ranged widely (nd-35,544 and nd-16,344 ng kg −1 , respectively). Antibiotics and estrogens varied spatially in the study area and mostly came from untreated wastewater. Antibiotics and estrogens were associated with water parameters such as pH and total nitrogen. A significant positive correlation was observed between estriol and levofloxacin concentrations (r = .65; p < .01), indicating that levofloxacin from the same source might have inhibited the microbiological degradation of estriol in the surface water. Overall, the estrogens pose a more severe risk than antibiotics to the Chaohu Lake system. However, co-occurrence of antibiotics may affect the fate of estrogens in the same lake media. More attention should be given to estrogens than to antibiotics in wastewater-affected lake systems.

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Degradation and transformation of fluoroquinolones by microorganisms with special emphasis on ciprofloxacin

Cited by 82 publications

References 120 publications

Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Biotransformation of lincomycin and fluoroquinolone antibiotics by the ammonia oxidizers AOA, AOB and comammox: A comparison of removal, pathways, and mechanisms

Co‐occurrence characteristics of antibiotics and estrogens and their relationships in a lake system affected by wastewater

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