Degradation, hemolysis, and cytotoxicity of silane coatings on biodegradable magnesium alloy

Gu, Xuenan; Guo, Hongjian; Wang, F.; Lu, Yun; Lin, Wenting; Li, J.; Zheng, Yufeng; Fan, Yubo

doi:10.1016/j.matlet.2017.01.136

Cited by 49 publications

(18 citation statements)

References 11 publications

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“…Shangguan et al applied the pulsed electrochemical deposition (PED) on Mg–1.5Sr and observed an improvement in corrosion resistance and reduction in the H 2 evolution of both the as‐extruded and as‐cast alloy in HBSS . This method has also been used to obtain saline coatings and layer by layer TiO 2 coatings on Mg alloys. Both these coatings improved corrosion resistance of Mg alloys and showed good cytocompatibility.…”

Section: Coating Techniques Applied For Mg Alloysmentioning

confidence: 99%

The current trends of Mg alloys in biomedical applications—A review

2018

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Magnesium (Mg) has emerged as an ideal alternative to the permanent implant materials owing to its enhanced properties such as biodegradation, better mechanical strengths than polymeric biodegradable materials and biocompatibility. It has been under investigation as an implant material both in cardiovascular and orthopedic applications. The use of Mg as an implant material reduces the risk of long-term incompatible interaction of implant with tissues and eliminates the second surgical procedure to remove the implant, thus minimizes the complications. The hurdle in the extensive use of Mg implants is its fast degradation rate, which consequently reduces the mechanical strength to support the implant site. Alloy development, surface treatment, and design modification of implants are the routes that can lead to the improved corrosion resistance of Mg implants and extensive research is going on in all three directions. In this review, the recent trends in the alloying and surface treatment of Mg have been discussed in detail. Additionally, the recent progress in the use of computational models to analyze Mg bioimplants has been given special consideration.

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Section: Coating Techniques Applied For Mg Alloysmentioning

confidence: 99%

The current trends of Mg alloys in biomedical applications—A review

2018

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“…Three of the studies mentioned in section 3.0 have included in vitro cell viability tests as a compliment to reports centered on biocorrosion activity . The results each show silane coatings to be nontoxic to cells with comparable rates of cell spreading and adhesion to a control sample.…”

Section: Biocompatibilitymentioning

confidence: 99%

“…Gu et al showed that cathodically deposited TEOS coatings on a magnesium alloy could reduce corrosion current densities by two orders of magnitude and long‐term hydrogen evolution volumes by 80%. Furthermore, altering cathodic deposition potential had a noticeable impact on film thickness, pitting and hydrogen evolution, with that of −2.0 V resulting in the optimal coating.…”

Section: Biocorrosionmentioning

confidence: 99%

“…Excessive hydrogen evolution is a known issue of magnesium implants, associated with many adverse side effects like localized tissue inflammation and disruptions to the blood stream. 58,69 Gu et al 62 showed that cathodically deposited TEOS coatings on a magnesium alloy could reduce corrosion current densities by two orders of magnitude and long-term hydrogen evolution volumes by 80%. Furthermore, altering cathodic deposition potential had a noticeable impact on film thickness, pitting and hydrogen evolution, with that of 22.0 V resulting in the optimal coating.…”

Section: Biocorrosionmentioning

confidence: 99%

“…Three of the studies mentioned in section 3.0 have included in vitro cell viability tests as a compliment to reports centered on biocorrosion activity. [62][63][64] The results each show silane coatings to be nontoxic to cells with comparable rates of cell spreading and adhesion to a control sample. Cell culture types included L929 mouse fibroblast cells, MG-63 osteosarcoma cells, AR75 rat thoracic muscle cells and human umbilical vein endothelial cells.…”

Section: Cytocompatibilitymentioning

confidence: 99%

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Silane coatings of metallic biomaterials for biomedical implants: A preliminary review

Somasundaram

2018

J Biomed Mater Res

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In response to increased attention in literature, this work provides a qualitative review surrounding the application of silane-based coatings of metallic biomaterials for biomedical implants. Included herein is both a brief summary of existing knowledge and concepts regarding silane-based thin films, along with an analysis of recent peer-reviewed publications and advances towards their practical application for biomedical coatings. Specifically, the review identifies innovative silane-based coatings according to their molecular identity and film structure and analyses their impact on the biocorrosion resistance, protein adsorption, cell viability, and antimicrobial properties of the overall coated implant. It is shown that a range of common silanes clearly exhibit promising properties for biomedical implant coatings, but further work is needed, particularly on mechanisms of physiological interaction and characteristic effects of silane functional groups, before seeing clinical use. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2901-2918, 2018.

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