Degradation Mechanisms for Water-Soluble Drugs in Solid Dosage Forms

Impact of Deliquescence on the Chemical Stability of Vitamins B1, B6, and C in Powder Blends

“…It is perhaps unsurprising that thiamin HCl is susceptible to degradation above the deliquescence point since a major mechanism of degradation is via hydrolysis. Others have reported thiamin HCl instability in intermediate-moisture foods (19,20). Generally, our findings on thiamin stability in the presence of moisture are in agreement with previous results.…”

Hygroscopicity of a sugarless coating layer formed by the interaction between mannitol and poly(vinyl alcohol) (PVA)

“…As has been previously reported in studies on the relationship between water content and degradation of water-soluble [2][3][4][5] and waterinsoluble drugs, the water content of solid oral dosage forms should be low in order to stabilize the solid drug content during storage.…”

Vitamins in Pharmaceutical Formulations

“…Bolatre et al (246) determined that ascorbic acid in tablets can discolor badly without much change in ascorbic acid content. Carstensen et al (247) studied the degradation of thiamine tableted with magnesium stearate and microcrystalline cellulose. As the moisture level was increased to 5.5%, thiamine loss increased, but at higher moisture levels stability was enhanced with increased moisture content.…”