1998
DOI: 10.1016/s0039-9140(97)00253-1
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Degradation of ampicillin in the presence of cadmium (II) ions

Abstract: Cadmium (II) ion-catalyzed degradation of ampicillin in methanol at 20°C has been studied. It has been observed that the rate values tend to saturate when the concentration of ampicillin or the metal ion is increased. The results obtained in the present study suggest that ampicillin degradation occurs through the formation of a 1:1 (SM) and 2:1 (S 2 M) ampicillin-metal complexes. These complexes decompose giving a single product (absorption maximum at 285 nm; (p =1.82×10 4 l mol − 1 cm − 1) that has been isola… Show more

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Cited by 31 publications
(5 citation statements)
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“…Penicillins are a very important class among β-lactamic antibiotics for their considerable activity against bacteria, assuming an essential biological role in the treatment of several diseases. , In recent years, the chemistry of this antibiotic class has aroused significant interest in relation to its biological activities. , It has been known that all β-lactamic antibiotics interact in in vivo systems with several metal cations, forming metal complex species, and their bioavailability can be enhanced or reduced owing to the interaction with metal cations. Therefore, it is crucial to assess the chemical interaction of penicillins with some important metal cations having biological roles in the human body . The assessment of the interactions between penicillins and a biologically relevant metal cation, such as calcium, is of crucial importance for understanding the in vivo mode of action of these ligands .…”
Section: Introductionmentioning
confidence: 99%
“…Penicillins are a very important class among β-lactamic antibiotics for their considerable activity against bacteria, assuming an essential biological role in the treatment of several diseases. , In recent years, the chemistry of this antibiotic class has aroused significant interest in relation to its biological activities. , It has been known that all β-lactamic antibiotics interact in in vivo systems with several metal cations, forming metal complex species, and their bioavailability can be enhanced or reduced owing to the interaction with metal cations. Therefore, it is crucial to assess the chemical interaction of penicillins with some important metal cations having biological roles in the human body . The assessment of the interactions between penicillins and a biologically relevant metal cation, such as calcium, is of crucial importance for understanding the in vivo mode of action of these ligands .…”
Section: Introductionmentioning
confidence: 99%
“…The degradation of β‐lactam antibiotics in the presence of metal ions may also contribute to the decrease of their antimicrobial effect (Gensmantel et al, 1980 ; Deshpande et al, 2004 ). As an example, Cd(II) was reported to catalyze the degradation of ampicillin in methanol (García et al, 1998 ) or in Luria‐Bertani bacterial growth medium (Beard et al, 1992 ). Nevertheless, the results are diverse and depend on many factors, such as the type of bacteria studied, the applied media and concentrations, etc.…”
Section: Resultsmentioning
confidence: 99%
“…Segundo este autor o íon que fornece a menor energia de ativação é o íon Zn 2+ , cujo valor é 34,6kJ mol -1 , e na ausência deste íon a energia de ativação é de 114,6 kJ mol -1 . Em outro artigo o mesmo autor [12] estuda a formação de complexo de 1:1 e 2:1 de (ampilicilina/cádmio) e a constante de velocidade de degradação do complexo 1:1. Além disto, o autor estuda as alterações estruturais por meio de RMN e verifica o surgimento de grupamento éster e quebra do anel β-lactâmico.…”
Section: Resultsunclassified