Degradation of curcumin‐mediated photodynamic technology (PDT) on polycyclic aromatic hydrocarbons in oysters and toxicity evaluation of PDT‐treated oysters

Abstract

Summary This study investigated the degradation effect of curcumin‐mediated photodynamic technology (PDT) on polycyclic aromatic hydrocarbons (PAHs) in oysters, and evaluated the safety of PDT‐treated oysters through acute and subacute toxicity experiments. The results demonstrated that curcumin‐mediated PDT could effectively degrade multi‐component PAHs in oysters, the maximum removal efficiency could reach 80.20% (10 μmol L−1 curcumin concentration and 54 J cm−2 light energy density). Acute toxicity experiment revealed PDT‐treated oysters did not cause any mortality and adverse symptoms in mice at an oral dose of 40 g kg−1 BW. Besides, after being treated at the dose of 10 g kg−1 BW for 28 days, the rats showed no obvious abnormal change in the indicators including the body weight, food utilisation, urology, haematology, serum biochemistry, organ index and histopathology. These findings show curcumin‐mediated PDT is a potentially efficacious method to degrade PAHs in oysters, and PDT‐treated oysters have high edible safety.

Association between polycyclic aromatic hydrocarbons exposure with red cell width distribution and ischemic heart disease: insights from a population-based study

“…While only a few studies have examined this association in animal models or case studies with small sample sizes, our findings offer valuable insights. Zhi et al (2022) observed no significant impact of PAH-treated oysters on rat RDW-CV 33 , while Booker & White (2005) reported a dose–response relationship between Benzo(a)pyrene (BaP) and RDW in mice exposed to varying concentrations of BaP 34 . In a study of 53 petrochemical plant workers, Wang et al (2015) found significant non-parametric Spearman correlations between urinary 1-OHP concentration and red cell indices MCH and RDW 35 .…”