Degradation of intestinal glycoproteins by Bacteroides vulgatus

Embden, J Ruseler-van

doi:10.1016/0378-1097(89)90338-8

Cited by 27 publications

(20 citation statements)

References 18 publications

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“…Similar results were previously observed using culture, PCR-cloning-sequencing, and FISH. 14,17,18 Interestingly, B. vulgatus degrades mucus 26 and initiates colitis in transgenic HLA-B27 rats. 27 Similarly, the Ruminococcus gnavus subgroup belonging to the C. coccoides group is known to degrade mucins.…”

Section: Discussionmentioning

confidence: 97%

Patchy distribution of mucosal lesions in ileal Crohnʼs disease is not linked to differences in the dominant mucosa-associated bacteria

Vasquez

Mangin

Lepage

et al. 2007

Inflammatory Bowel Diseases

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Section: Discussionmentioning

confidence: 97%

Patchy distribution of mucosal lesions in ileal Crohnʼs disease is not linked to differences in the dominant mucosa-associated bacteria

Vasquez

Mangin

Lepage

et al. 2007

Inflammatory Bowel Diseases

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“…Bacteroides vulgatus isolated from IBD patients secrete mucin‐degrading enzymes. 52 However, lower levels of sulfate on Muc2 could also be beneficial, since fewer sulfates available for metabolism by sulfate‐reducing bacteria could result in less production of toxic sulfides. Increased numbers of sulfate‐reducing bacteria have been demonstrated in ulcerative colitis patients.…”

Section: Discussionmentioning

confidence: 99%

Interleukin 10-Deficient Mice Exhibit Defective Colonic Muc2 Synthesis Before and After Induction of Colitis by Commensal Bacteria

Schwerbrock

Makkink

Sluis

et al. 2004

Inflammatory Bowel Diseases

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Germ-free (GF) interleukin 10-deficient (IL-10) mice develop chronic colitis after colonization by normal enteric bacteria. Muc2 is the major structural component of the protective colonic mucus. Our aim was to determine whether primary or induced aberrations in Muc2 synthesis occur in GF IL-10 mice that develop colitis after bacterial colonization. GF IL-10 and wild-type mice were colonized with commensal bacteria for various intervals up to 6 weeks. Colitis was quantified by histologic score and IL-12 secretion. Muc2 synthesis, total level of Muc2, and Muc2 sulfation were measured quantitatively. GF IL-10 mice showed 10-fold lower Muc2 synthesis and Muc2 levels compared with GF wild-type mice, but Muc2 sulfation was not different. When bacteria were introduced, IL-10 mice developed colitis, whereas wild-type mice remained healthy. Muc2 synthesis was unchanged in wild-type mice, but IL-10 mice showed a peak increase in Muc2 synthesis 1 week after bacterial introduction, returning to baseline levels after 2 weeks. Total Muc2 levels decreased 2-fold in wild-type mice but remained at stable low levels in IL-10 mice. Upon introducing bacteria, Muc2 sulfation increased 2-fold in wild-type mice, whereas in IL-10 mice Muc2 sulfation decreased 10-fold. In conclusion, a primary defect in colonic Muc2 synthesis is present in IL-10 mice, whereas bacterial colonization and colitis in these mice led to reduced Muc2 sulfation. These quantitative and structural aberrations in Muc2 in IL-10 mice likely reduce the ability of their mucosa to cope with nonpathogenic commensal bacteria and may contribute to their susceptibility to develop colitis.

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“…These results therefore suggested that the Bacteroides species have an invasive effect on the host enteric tissue thereby causing a systemic antibody response even though they are considered to be commensal bacteria. Indeed, B. vulgatus has been reported to produce mucindegrading enzymes, which could profoundly affect the mucosal barrier function (20). Furthermore, the outer membrane antigens of B. vulgatus were found to be intimately associated with the enhancement of inflammation in a carrageenan-induced IBD model (4).…”

Section: Discussionmentioning

confidence: 99%

The Suppressive Effect of Bifidobacteria on Bacteroides vulgatus, a Putative Pathogenic Microbe in Inflammatory Bowel Disease

Shiba

Aiba

Ishikawa

et al. 2003

Microbiology and Immunology

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Bacteroides, a predominant commensal bacteria in the gut, are thought to be responsible for the development of inflammatory bowel disease (IBD). In the present study, we examined whether or not bifidobacteria suppress B. vulgatus, a representative pathogenic Bacteroides species, in both the coculture system and the gnotobiotic murine model. As a result, Bifidobacterium infantis 1222 highly inhibited the growth of B. vulgatus in the coculture and also significantly suppressed the systemic antibody response raised by B. vulgatus colonizing the gut in gnotobiotic mice. Colonization of the mice by B. vulgatus increased the number of Peyer's patch (PP) cells bearing PNA (peanut agglutinin)+/anti‐κ+ phenotype, which represents plasma cell‐like B cells. Moreover, treatment of those B. vulgatus‐implanted mice with B. infantis 1222 abrogated such increase in the number of PNA+/anti‐κ+ cells. These results thus suggested that B. infantis 1222 protected the gut epithelial layer including the PP from being invaded by Bacteroides, thereby suppressing the systemic antibody response raised by Bacteroides.

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Degradation of intestinal glycoproteins by Bacteroides vulgatus

Cited by 27 publications

References 18 publications

Patchy distribution of mucosal lesions in ileal Crohnʼs disease is not linked to differences in the dominant mucosa-associated bacteria

Patchy distribution of mucosal lesions in ileal Crohnʼs disease is not linked to differences in the dominant mucosa-associated bacteria

Interleukin 10-Deficient Mice Exhibit Defective Colonic Muc2 Synthesis Before and After Induction of Colitis by Commensal Bacteria

The Suppressive Effect of Bifidobacteria on Bacteroides vulgatus, a Putative Pathogenic Microbe in Inflammatory Bowel Disease

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