Degradation of Selected Acidic and Neutral Pharmaceutical Products in a Primary-Treated Wastewater by Disinfection Processes

Gagnon, Christian; Lajeunesse, André; Čejka, Patrick; Gagné, François; Häusler, Robert

doi:10.1080/01919510802336731

Cited by 78 publications

(39 citation statements)

References 24 publications

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“…Ikehata et al (2006) described complete degradation by several AOPs in high quality wastewater. Gagnon et al (2008) reported an elimination of 80% (with O 3 concentration ranged from 15 to 30 mg l -1 ) for primary-treated wastewater. Removal of DCF by the white rot fungus Phanerochaete sordida in a 6-day period has also been demonstrated, reporting the removal of the acute lethal toxicity (Hata et al 2010a).…”

Section: Antibiotics: Sulfamethoxazolementioning

confidence: 98%

“…The authors suggested that both the ligninolytic enzyme laccase and the intracellular enzyme cytochrome P-450 played a role in NPX degradation. Other alternatives to enzymatic/fungal treatment could be based on the use of ozone as a processing technique, but a high O 3 concentration (15 mg l -1 ) is also necessary for a complete removal of NPX (Gagnon et al 2008). Degradability of DCF is low in the aerobic biological treatment (up to 30%) and highly variable in the anaerobic treatment (between 0 and 75%) (Carballa et al 2004).…”

Section: Antibiotics: Sulfamethoxazolementioning

confidence: 99%

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Oxidation of pharmaceutically active compounds by a ligninolytic fungal peroxidase

et al. 2010

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Pharmaceuticals are an important group of emerging pollutants with increasing interest due to their rising consumption and the evidence for ecotoxicological effects associated to trace amounts in aquatic environments. In this paper, we assessed the potential degradation of a series of pharmaceuticals: antibiotics (sulfamethoxazole), antidepressives (citalopram hydrobromide and fluoxetine hydrochloride), antiepileptics (carbamazepine), anti-inflammatory drugs (diclofenac and naproxen) and estrogen hormones (estrone, 17β-estradiol, 17α-ethinylestradiol) by means of a versatile peroxidase (VP) from the ligninolytic fungus Bjerkandera adusta. The effects of the reaction conditions: VP activity, organic acid concentration and H(2)O(2) addition rate, on the kinetics of the VP based oxidation system were evaluated. Diclofenac and estrogens were completely degraded after only 5-25 min even with a very low VP activity (10 U l(-1)). High degradation percentages (80%) were achieved for sulfamethoxazole and naproxen. Low or undetectable removal yields were observed for citalopram (up to 18%), fluoxetine (lower than 10%) and carbamazepine (not degraded).

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Section: Antibiotics: Sulfamethoxazolementioning

confidence: 98%

Section: Antibiotics: Sulfamethoxazolementioning

confidence: 99%

Oxidation of pharmaceutically active compounds by a ligninolytic fungal peroxidase

et al. 2010

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“…The used doses have been significantly higher compared to the disinfection of wastewater: ranging from 40 to 20 000 mg/L. In fact, smaller doses of PFA or PAA were unable to degrade pharmaceutical residues [225,226].…”

Section: Oxidation Of Aqueous Pollutantsmentioning

confidence: 99%

Peracids in water treatment: A critical review

Luukkonen

Pehkonen

2016

Critical Reviews in Environmental Science and Technology

271

122

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Peracids have gained interest in the water treatment over the last few decades. Peracetic acid (CH 3 CO 3 H) has already become an accepted alternative disinfectant in wastewater disinfection whereas performic acid (CHO 3 H) has been studied much less, although it is also already commercially available. Peracids have also been tested for drinking water disinfection, oxidation of aqueous (micro)pollutants, sludge treatment and ballast water treatment, to name just a few examples. The purpose of this review paper is to represent comprehensive up-to-date information about the water treatment applications, aqueous reaction mechanisms, and disinfection byproduct formation of peracids, namely performic, peracetic and perpropionic acids. and PFA have several of the qualities of an ideal disinfectant: toxicity to microorganisms, but not to higher forms of life; effectivity at ambient temperatures; stability and long shelf-life; low corrosivity; deodorizing ability; widespread availability and reasonable cost [12].PAA and PFA are colorless liquids with characteristic pungent odors. Both are thermodynamically unstable and can decompose spontaneously or explode when highly concentrated, heated, under mechanical stress or exposed to catalytic effects of impurities [1,13,14]. The recommended storage temperatures are below 30 and 20°C for PAA and PFA, respectively [6,14]. Longer carbon chain length increases stability, and thus PAA is more stable than PFA [1]. However, the O-O bond dissociation energy of PFA and PAA has been calculated to be similar: 48 kcal/mol [15]. Percarboxylic acids have typically pK a values 3-4 units higher than the parent carboxylic acids [1]. Nonetheless, PFA and PAA are corrosive [16]. ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 3Exposure to PAA and PFA causes irritation and possibly permanent damage to the skin (cutaneous emphysema), eyes and the respiratory system. In the skin contact, 0.2% is proposed as the no-observed-effect concentration (NOEC) for short and medium length exposure [17].When inhaled, airborne concentrations less than 0.16-0.17 ppm (0.50-0.52 mg/m 3 ) are considered to cause no irritation [17,18]. However, higher concentrations are harmful and a case study suggested that PAA could cause occupational asthma [19].The largest users of PAA on a global scale (estimated in 2013) are shown in Fig. 1. Similar numbers are not available for PFA, but it is probably used at significantly lower quantities.The largest user, the food industry, applies PAA as a disinfectant in fresh produce washing water, clean-in-place (CIP) processes, on food processing equipment, and in pasteurizers, to name just a few examples [21,22]. PFA is also a suitable disinfectant in low-temperature refrigerated food processing and storage rooms [23]. In healthcare, PAA is used for instance in Recently, methods to determine the residual PAA from wastewater were compared: the spectrophotometric method using DPD and catalase was recommended for 0.1-0.5 mg/L PAA concentrations and the cerimetric/iodometric titration...

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“…In the case of advanced technologies, higher removal efficiencies for antiinflammatory compounds were achieved by using ozone (up to 100% for naproxen, NPX) or by a photoFenton system (80-100% for ibuprofen, IBP). However, other pharmaceutical compounds presented intermediate elimination percentages (50-70%) (Gagnon et al 2008;Méndez-Arriaga et al 2010). Emerging technologies, such as those based on the use of WRF or the ligninolytic enzymes have attained promising results, with degradation yields close to 100% for diclofenac (DCF) as pointed out by Lloret et al (2010) and Marco-Urrea et al (2010a).…”

Section: Introductionmentioning

confidence: 97%

Biotransformation of three pharmaceutical active compounds by the fungus Phanerochaete chrysosporium in a fed batch stirred reactor under air and oxygen supply

et al. 2011

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White-rot fungi are a group of microorganisms capable of degrading xenobiotic compounds, such as polycyclic aromatic hydrocarbons or synthetic dyes, by means of the action of extracellular oxidative enzymes secreted during secondary metabolism. In this study, the transformation of three anti-inflammatory drugs: diclofenac, ibuprofen and naproxen were carried out by pellets of Phanerochaete chrysosporium in fed-batch bioreactors operating under continuous air supply or periodic pulsation of oxygen. The performance of the fungal reactors was steady over a 30-day treatment and the effect of oxygen pulses on the pellet morphology was evidenced. Complete elimination of diclofenac was achieved in the aerated and the oxygenated reactors, even with a fast oxidation rate in the presence of oxygen (77% after 2 h), reaching a total removal after 23 h. In the case of ibuprofen, this compound was completely oxidized under air and oxygen supply. Finally, naproxen was oxidized in the range of 77 up to 99% under both aeration conditions. These findings demonstrate that the oxidative capability of this microorganism for the anti-inflammatory drugs is not restricted to an oxygen environment, as generally accepted, since the fungal reactor was able to remove these compounds under aerated and oxygenated conditions. This result is very interesting in terms of developing viable reactors for the oxidation of target compounds as the cost of aeration can be significantly reduced.

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Degradation of Selected Acidic and Neutral Pharmaceutical Products in a Primary-Treated Wastewater by Disinfection Processes

Cited by 78 publications

References 24 publications

Oxidation of pharmaceutically active compounds by a ligninolytic fungal peroxidase

Oxidation of pharmaceutically active compounds by a ligninolytic fungal peroxidase

Peracids in water treatment: A critical review

Biotransformation of three pharmaceutical active compounds by the fungus Phanerochaete chrysosporium in a fed batch stirred reactor under air and oxygen supply

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