Degradation of Selected Antidepressants Sertraline and Citalopram in Ultrapure Water and Surface Water Using Gamma Radiation

Bojanowska-Czajka, Anna; Pyszynska, Marta; Majkowska-Pilip, Agnieszka; Wawrowicz, Kamil

doi:10.3390/pr10010063

Cited by 9 publications

(5 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This behavior can be attributed to the higher surface area and more free active sites of ZnO-NPs than those of the bulk ZnO counterpart. Comparing our results with other methods reported in the literature for the removal of SERT using TiO 2 /light or gamma radiation [44][45][46], we found the ZnO-NPs to be the most efficient photocatalyst for the removal of SERT in water within a short time.…”

Section: Comparison Of the Catalytic Activity Of Zno-nps And Bulk Zno...supporting

confidence: 75%

Enhanced Photocatalytic Degradation of the Antidepressant Sertraline in Aqueous Solutions by Zinc Oxide Nanoparticles

Mohamed

Riyad

Hendawy

et al. 2023

Water

View full text Add to dashboard Cite

Antidepressants are one of the main pollutants in the aquatic environment. They are being widely studied due to their widespread use, possible health effects, and partial removal from wastewater treatment plants by conventional methods. Photocatalysis is an effective and ecologically beneficial method in wastewater treatment. In the present study, the photocatalytic degradation of sertraline hydrochloride (SERT) in water using nano-sized zinc oxide (ZnO-NPs) was investigated. The ZnO-NPs were synthesized from zinc gluconate as a precursor by the sol–gel method. The crystal structure, morphology, surface charge, and textural properties were characterized by X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray analyses, transmission electron microscopy, Fourier-transform infrared spectroscopy, zeta potential, and N2 adsorption–desorption measurements. The removal of SERT in water was explored by different processes: H2O2/UV, ZnO-NPs/H2O2/UV, and ZnO-NPs/UV. Our results indicate that the combination of both UV illumination and the ZnO-NP as a catalyst was necessary for the efficient degradation of the drug. Nearly complete removal of SERT (98.7%) was achieved in 30 min with the ZnO-NPs/UV process at room temperature. The photodegradation of SERT follows first-order kinetics with a rate constant of 0.0678 min−1. The results reveal that SERT degradation with ZnO-NPs/UV is pH-dependent, as the maximum drug removal was achieved at pH 11. Initial drug concentration, catalyst dose, and hydrogen peroxide concentration were also crucial in the removal of SERT. Our findings indicate that the high specific surface area and porous structure of ZnO-NP enhance its photocatalytic performance toward photodegradation of SERT, i.e., ZnO-NP is an efficient nanophotocatalyst for the degradation of SERT under UV irradiation.

show abstract

Section: Comparison Of the Catalytic Activity Of Zno-nps And Bulk Zno...supporting

confidence: 75%

Enhanced Photocatalytic Degradation of the Antidepressant Sertraline in Aqueous Solutions by Zinc Oxide Nanoparticles

Mohamed

Riyad

Hendawy

et al. 2023

Water

View full text Add to dashboard Cite

show abstract

“…An alternative to UV radiation is represented by ionizing radiation, namely gamma (γ) radiation. Bojanowska-Czajka et al investigated the γ-ray-inflicted degradation of SER and CIT in surface water, including in the presence of commonly encountered radical scavengers such as CO 3 2− , NO 3 − , and humic acid [67]. As γ radiation source, 60 Co was used, with radiation doses between zero and 500 Gy.…”

Section: Advanced Oxidation Processes (Aops)mentioning

confidence: 99%

Wastewater Treatment Approaches for the Removal of Antidepressant Residues

C. Racovita,

D. Ciuca

2024

Wastewater Treatment - Past and Future Perspectives [Working Title]

View full text Add to dashboard Cite

Pharmaceuticals are a major class of contaminants of emerging concern for wastewaters and natural waters alike. Among pharmaceuticals, antidepressants are the most rapidly increasing subclass, as more and more people are dealing with depression in their fast-paced and challenging everyday lives. As psychotropic medications, residual antidepressants in water must be carefully monitored and maintained below levels, where human health may be endangered. Moreover, aquatic life forms were shown to be seriously affected when such pollutants entered their natural habitat, in terms of locomotory, reproductive functions, or social behavior. Therefore, modern wastewater treatment plant technologies should incorporate solutions for removing antidepressant residues. This chapter summarizes recent efforts toward this goal and covers a wide range of proposed treatment approaches. Firstly, adsorptive methods are presented, whether based on classic, yet effective adsorbents like activated carbon or silicates, or modern alternatives such as ion-exchange resins or molecularly imprinted polymers. Secondly, extractive methods are considered, although currently impractical due to lack of both cheap and environmentally-benign solvents. Thirdly, advanced oxidation processes are surveyed, including ozone treatment, ultraviolet, gamma radiation, and electrochemical options, some of which, alone or in combination, may yield complete mineralization of antidepressant toxicants. Lastly, biological treatment with microorganisms is discussed, which may be highly specific, but usually does not enable a complete mineralization.

show abstract

“…Oxidative degradation can be catalyzed by light, metal ions, or other species, leading to the generation of reactive oxygen species. This process mainly exposes unsaturated bonds, which are prone to undergoing oxidation by many mild or strong oxidants [4,8,27].…”

Section: Degradation Pathways For Antidepressant Drugsmentioning

confidence: 99%

“…In other words, ~1 billion people suffer from some form of mental health condition. During the COVID-19 pandemic, anxiety and depressive disorders rose to a whopping 28% [4][5][6][7][8][9]19,23,[27][28][29][30][31][32]. There are many types of mental disorders that can cause disturbances in cognition, behavior, or emotional regulation [6,14,15].…”

Section: Introductionmentioning

confidence: 99%

An Overview of Degradation Strategies for Amitriptyline

Comanescu,

Racovita

2024

IJMS

View full text Add to dashboard Cite

Antidepressant drugs play a crucial role in the treatment of mental health disorders, but their efficacy and safety can be compromised by drug degradation. Recent reports point to several drugs found in concentrations ranging from the limit of detection (LOD) to hundreds of ng/L in wastewater plants around the globe; hence, antidepressants can be considered emerging pollutants with potential consequences for human health and wellbeing. Understanding and implementing effective degradation strategies are essential not only to ensure the stability and potency of these medications but also for their safe disposal in line with current environment remediation goals. This review provides an overview of degradation pathways for amitriptyline, a typical tricyclic antidepressant drug, by exploring chemical routes such as oxidation, hydrolysis, and photodegradation. Connex issues such as stability-enhancing approaches through formulation and packaging considerations, regulatory guidelines, and quality control measures are also briefly noted. Specific case studies of amitriptyline degradation pathways forecast the future perspectives and challenges in this field, helping researchers and pharmaceutical manufacturers to provide guidelines for the most effective degradation pathways employed for minimal environmental impact.

show abstract

Degradation of Selected Antidepressants Sertraline and Citalopram in Ultrapure Water and Surface Water Using Gamma Radiation

Cited by 9 publications

References 54 publications

Enhanced Photocatalytic Degradation of the Antidepressant Sertraline in Aqueous Solutions by Zinc Oxide Nanoparticles

Enhanced Photocatalytic Degradation of the Antidepressant Sertraline in Aqueous Solutions by Zinc Oxide Nanoparticles

Wastewater Treatment Approaches for the Removal of Antidepressant Residues

An Overview of Degradation Strategies for Amitriptyline

Contact Info

Product

Resources

About