Degree of Damage to the Small Bowel and Serum Antibody Titers Correlate With Clinical Presentation of Patients With Celiac Disease

Taavela, Juha; Kurppa, Kalle; Collin, Pekka; Lähdeaho, Marja–Leena; Salmi, Teea; Saavalainen, Päivi; Haimila, Katri; Huhtala, Heini; Laurila, Kaija; Sievänen, Harri; Mäki, Markku; Kaukinen, Katri

doi:10.1016/j.cgh.2012.09.030

Cited by 67 publications

(61 citation statements)

References 43 publications

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“…40 Earlier studies have yielded inconsistent results on the correlation between clinical picture and histological findings in celiac disease. 20,[41][42][43] Apart from differences in study designs these discrepancies might be at least partly explained by differences in clinical presentation of the disease between countries. During recent decades, studies from many developed countries have reported that the severity of celiac disease is becoming milder even in the subgroup of patients suffering from classical gastrointestinal symptoms, 44,45 which may contribute to the increasing similarity between clinically and screen-detected children.…”

Section: Discussionmentioning

confidence: 99%

At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study

Kivelä

Kaukinen

Huhtala

et al. 2017

The Journal of Pediatrics

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Section: Discussionmentioning

confidence: 99%

At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study

Kivelä

Kaukinen

Huhtala

et al. 2017

The Journal of Pediatrics

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“…Some studies have suggested that GFD may have an anti-atherosclerotic effect in CD [22][23][24] , whereas others have shown that the diet is likely to be atherogenic [25][26][27] . Serum total cholesterol level was significantly lower in CD compared to healthy controls in our study as reported previously in the adults 22,26 .…”

Section: Discussionmentioning

confidence: 99%

Carotid intima-media thickness and arterial stiffness as early markers of atherosclerosis in pediatric celiac disease

et al. 2016

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The association between pediatric celiac disease (CD) and atherosclerosis is unknown. Our aim was to investigate whether pediatric CD patients have an increased risk of atherosclerosis. We evaluated the premature atherosclerosis by pulse wave velocity (PWV) and carotid intima-media thickness (cIMT). A total of 37 CD patients (20 girls, mean age 13±3.3 years) and 36 healthy age and sex matched controls were enrolled. Mean duration of CD was 47.1±32.3 months and 40.5% of patients had positive tissue transglutaminase antibody (tTg) IgA. Total cholesterol level was lower in CD (p=0.026) and cIMT was lower in tTg IgA antibody negative CD (p=0.030). cIMT was significantly correlated with tTg IgA antibody positivity (r=0.336; p=0.042). Adherence to strict gluten-free diet is associated with decreased cIMT, suggesting that gluten withdrawal seems to have a beneficial effect on premature atherosclerosis.

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“…[24][25][26] Moreover, scores on gastrointestinal symptoms correlate with tTGA levels in adult patients, 26 and young children with severe signs of malabsorption have significantly higher tTGA levels than older children presenting with nonspecific symptoms. 24 In our cohort, symptomatic children with CDA and CD had higher tTGA levels at seroconversion.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Celiac Disease: A Prospective Birth Cohort

et al. 2015

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To investigate clinical features of celiac disease (CD) and their association with risk factors for CD in a genetic risk birth cohort.METHODS: Children from 6 clinical centers in 4 countries positive for HLA-DR3-DQ2 or DR4-DQ8 were annually screened for tissue transglutaminase antibodies (tTGA) and assessed for symptoms by questionnaires. Associations of symptoms with anthropometrics, known risk factors for CD, tTGA levels, and mucosal lesions in those biopsied were examined.RESULTS: Of 6706 screened children, 914 developed persistent positive tTGA, 406 underwent biopsies, and 340 had CD. Compared with age-matched tTGA-negative children, those with persistent tTGA were more likely to have symptoms at 2 (34% vs 19%, P , .001) and 3 years of age (28% vs 19%, P = .009) but not at 4 years (27% vs 21%, NS). Z-scores for height, weight, and BMI did not differ between groups. In children with persistent tTGA, having $1 symptom was associated with family history of CD (odds ratio = 2.59, 95% confidence interval, 1.21-5.57) but not with age, gender, or HLA-DR3-DQ2 homozygosity. At seroconversion, tTGA levels were higher in symptomatic than asymptomatic children (P , .001), in those from CD families (P , .001), and in US participants (P , .001) but not associated with age, gender, or HLA genotype. tTGA levels correlated with severity of mucosal lesions both in symptomatic (r = 0.53, P , .001) and asymptomatic children (r = 0.22, P = .01).

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Degree of Damage to the Small Bowel and Serum Antibody Titers Correlate With Clinical Presentation of Patients With Celiac Disease

Cited by 67 publications

References 43 publications

At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study

At-Risk Screened Children with Celiac Disease are Comparable in Disease Severity and Dietary Adherence to Those Found because of Clinical Suspicion: A Large Cohort Study

Carotid intima-media thickness and arterial stiffness as early markers of atherosclerosis in pediatric celiac disease

Clinical Features of Celiac Disease: A Prospective Birth Cohort

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