2020
DOI: 10.1016/j.jcrc.2019.11.003
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Degree of hyperglycemia independently associates with hospital mortality and length of stay in critically ill, nondiabetic patients: Results from the ANZICS CORE binational registry

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Cited by 19 publications
(22 citation statements)
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“…We and others have previously demonstrated that the degree of hyperglycemia in critically ill patients without diabetes plays a significant prognostic role in predicting hospital mortality. [8, 19, 20] Indeed, Max Harry Weil, father of critical care medicine, knew by 1973 that in critically ill patients, “Elevation of blood sugar reflects secretion of increased amounts of catecholamines from the adrenal medulla.”[21] Epinephrine-induced phosphorylation of the insulin receptor reduces its tyrosine kinase activity[22] and causes prompt and prolonged inhibition of pancreatic insulin secretion. [23] Thus, early appearance of hyperglycemia in non-diabetic COVID-19 patients likely signals increased systemic stress.…”
Section: Discussionmentioning
confidence: 99%
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“…We and others have previously demonstrated that the degree of hyperglycemia in critically ill patients without diabetes plays a significant prognostic role in predicting hospital mortality. [8, 19, 20] Indeed, Max Harry Weil, father of critical care medicine, knew by 1973 that in critically ill patients, “Elevation of blood sugar reflects secretion of increased amounts of catecholamines from the adrenal medulla.”[21] Epinephrine-induced phosphorylation of the insulin receptor reduces its tyrosine kinase activity[22] and causes prompt and prolonged inhibition of pancreatic insulin secretion. [23] Thus, early appearance of hyperglycemia in non-diabetic COVID-19 patients likely signals increased systemic stress.…”
Section: Discussionmentioning
confidence: 99%
“…However, this prognostic role of hyperglycemia varies by the primary cause of critical care such that primary diagnoses like trauma, coma and neurological diseases are especially prone to high likelihood of adverse outcomes associated with hyperglycemia. [8] Our results need to be viewed in the light of the emerging literature on association of hyperglycemia with COVID-19 prognosis. Studies have shown that pre-existing diabetes [2], newly detected diabetes [24], prediabetes [25], uncontrolled hyperglycemia (≥2 BG values of ≥10 mMol/L[3]) or fasting BG ≥7 mmol/L [26] are significant determinants of COVID-19 prognosis.…”
Section: Discussionmentioning
confidence: 99%
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“…Enfin, outre l’inflammation, l’hyperglycémie a été décrite dans la littérature comme étant un facteur de risque de sarcopénie. Cet élément est à prendre en compte au regard de l’importante prévalence du diabète chez les sujets présentant une forme grave de COVID-19 et de l’association déjà connue entre hyperglycémie et un devenir défavorable en réanimation [26] , [27] , [28] .…”
Section: Spécificités Des Malades Atteints Par Le Sars-cov-2unclassified
“…Stress hyperglycemia is common in trauma patients and critical illness upon hospital admission and is often associated with worse outcome [1][2][3][4]. Hemorrhage aggravates this stress hyperglycemia signi cantly [5,6].…”
Section: Introductionmentioning
confidence: 99%