Dehydration, electrolyte imbalances and renin‐angiotensin‐aldosterone‐vasopressin axis in successful and unsuccessful endurance horses

Muñoz, A.; Riber, C.; Trigo, P.; Castejón‐Riber, Cristina; Castejón, Francisco

doi:10.1111/j.2042-3306.2010.00211.x

Cited by 60 publications

(81 citation statements)

References 22 publications

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“…The sensitivity of this technique was of 15 pg/ml, and the intra-and inter-analysis CVs were 4.7-6.4% and 8.5-9.6%, respectively. These methods were validated for horses and have been used in previous researches (Munoz et al 2010;.…”

Section: Methodsmentioning

confidence: 99%

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

Satué¹,

Montesinos²,

Munos³

2017

CZECH J ANIM SCI

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Satué K., Montesinos P., Muños A. (2017): Activation of the renin-angiotensin-aldosterone system in mares around ovulation. Czech J. Anim. Sci., 62,[259][260][261][262][263][264][265][266][267] Many physiological events occurring during the estrous cycle, including folliculogenesis, oocyte maturation, ovulation, follicular atresia, corpus luteum development, luteolysis, steroidogenesis, and angiogenesis are associated with an increased expression of the renin-angiotensin-aldosterone system (RAAS) in uterus and ovarian follicles. This enhanced expression leads to a rise in plasma concentrations of these hormones in women and laboratory animals, and the same might happen in the mare. This study aims to assess if an activation of the RAAS occurs in mares around ovulation and if this activation is related to the diameter of the predominant follicle (DPF), packed cell volume (PCV), and electrolyte concentrations. Twenty-five healthy Spanish Purebred mares were sampled during the five days before ovulation, the day of ovulation, and the first five days after ovulation. Renin (REN) concentrations increased progressively during the five days before ovulation, achieving the highest values on the day of ovulation. Angiotensin (ANG) concentrations showed a sharp decrease after ovulation, with the lowest values the fifth day after it. Aldosterone (ALD) concentrations increased progressively, from the fifth day before ovulation until the fifth day after ovulation. The highest PCV values were found on the day of ovulation. There were no relevant correlations between the RAAS components and electrolytes concentrations. Before ovulation, there was a positive relationship between REN and ALD (r = 0.760) and after ovulation, a negative correlation between ANG and ALD (r = -0.660). The DPF was correlated with REN (r = 0.740) and with ALD (r = 0.800) concentrations. Ovulation in the mare is associated with high plasma REN concentrations, and therefore, with an activation of the RAAS. In addition, after ovulation, the sharp decrease in plasma REN and ANG concentrations might be a reflex of the modulation of the previously activated RAAS, although plasma ALD concentrations increased during this period.

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Section: Methodsmentioning

confidence: 99%

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

Satué¹,

Montesinos²,

Munos³

2017

CZECH J ANIM SCI

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“…These parameters, when taken together, suggest that the disqualified animals had severe degree of dehydration. Severe dehydration corroborates data from Muñoz et al (2010), which stated that the disqualified animals undergo more substantial changes in the homeostasis than animals more apt to exercise, derived from the increased water loss and electrolyte change.…”

Section: Analysis Of Hematocrit and Total Plasma Proteinsupporting

confidence: 75%

“…Outra consequência da transpiração excessiva é a depleção de eletrólitos, pois, o suor equino é isotônico ou ligeiramente hipertônico em relação ao plasma, contendo concentrações elevadas de Na + , K + e Cl -e moderadas de Ca +2 e Mg +2 (Teixeira-Neto et al 2004). Em função disto, a sudorese prolongada causa déficits significativos, promovendo a fraqueza, cãibras musculares, desequilíbrios ácido-base, arritmias cardíacas, diminuição do desempenho e, eventualmente, promovendo um quadro de exaustão (Muñoz et al 2010). A coleta de sangue venoso foi realizada de forma anaeróbica, por meio da punção da veia jugular, retirando-se 1,6ml, com seringas apropriadas para coleta de sangue para gasometria (3ml, 0,7x25mm, 22G -BD Preset Eclipse ® ), conforme descrito em Dumont et al (2012).…”

Section: A Influência Da Distância Na Desclassificação De Equinos De unclassified

A influência da distância na desclassificação de equinos de enduro : alterações hidroeletrolíticas, hemogasométricas e bioquímicas

Dumont¹

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Agris/FAO Documento formal, autorizando reprodução desta tese de doutorado para empréstimo ou comercialização, exclusivamente para fins acadêmicos, foi passado pelo autor à Universidade de Brasília e acha-se arquivado na Secretaria do Programa. O autor reserva para si os outros direitos autorais, de publicação. Nenhuma parte desta tese de doutorado pode ser reproduzida sem a autorização por escrito do autor. Citações são estimuladas, desde que citada a fonte. Dumont, Cinthia Beatriz da Silva A INFLUÊNCIA DA DISTÂNCIA NA DESCLASSIFICAÇÃO DE EQUINOS DE ENDURO -ALTERAÇÕES HIDROELETROLÍTICAS, HEMOGASOMÉTRICAS E BIOQUÍMICAS/ Cinthia Beatriz da Silva Dumont AGRADECIMENTOSAgradeço primeiramente a Deus e a espiritualidade maior pela ajuda em me fazer compreender e lidar com todas as situações de dificuldades durante não só na esfera profissional e acadêmica, mas também da vida cotidiana.Aos meus pais e avós pelo amor maior. Amo vocês, SAUDADES!!!!!! Meus mais sinceros agradecimentos ao meu orientador, Prof. Dr. Eduardo MaurícioMendes de Lima por mais essa oportunidade, pela confiança, pela paciência sem tamanho, pelas conversas, broncas e conselhos, pela orientação e amizade e por ter se tornado meu grande amigo. E também, minhas desculpas mais sinceras se deixei a desejar!!!!Ao amigo e chefe da equipe veterinária Meryonne Moreira, presente na minha formação profissional desde a época de estágios, pelo profissionalismo, competência e por permitir o trabalho durante a realização das provas.Aos amigos, Júlia Moraes, Ceci Ribeiro, Mariana Damázio e aqueles que foram fundamentais no trabalho de campo, durante a fase de colheita de material.Às equipes, tratadores e responsáveis pelos animais e a todos os enduristas que participaram deste estudo, pela cooperação, paciência, apoio, e parceria demonstrada nos momentos de colheitas. Às equipes do Medicalvet Laboratório Veterinário, na pessoa de RicardoSampaio e do Santé Laboratório, na pessoa de Gláucia Balsamão, que colocaram sua equipe à disposição para realização das análises mesmo fora do horário de expediente.Aos queridos colegas André Viana, Fabieni Okiama, Kaique Nogueira e Anna Eris, que foram incansáveis e fundamentais para a confecção, o término e a qualidade desse trabalho.Aos maravilhosos cavalos atletas, objeto de estudo desta pesquisa. Eles são a razão de tudo, devem ser respeitados e amados!!! ABSTRACTWe evaluated 18 horses that were disqualified from endurance race championships exclusively due to metabolic changes. The athlete horses were examined immediately after they had completed the 30, 40, 60, 72, 90 or 140 km races, before there was any clinical and therapeutic intervention for animal recovery. In the first experiment, the horses completed the 30, 60 or 90km races and the following parameters were measured immediately after: hematocrit levels, total plasma proteins (TPP), anion gap, base excess/deficit, osmolarity, pH, and the concentrations of hydrogen ions, bicarbonate, sodium, potassium, calcium and chlorine. In the second experiment, the horses comp...

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“…43.3). 25,26 Hence, where possible, assessment of PCV and plasma protein concentrations should be incorporated into the assessment of individual endurance horses considered at risk of metabolic derangement during competition. clinical signs or other clinicopathologic findings suggest the possibility of a muscular disorder, further diagnostics appropriate for assessment of muscular disorders should be pursued even if an exercise response test is inconclusive.…”

Section: Muscle Enzyme Activitiesmentioning

confidence: 99%

“…23,58 Some studies have identified more profound hypochloremia and other electrolyte derangements in endurance horses encountering metabolic problems during competition than in horses that complete events successfully, though the exact role of these specific imbalances in eliciting the clinical signs of concern is not always clear. [23][24][25][26] Conclusion Serum or plasma biochemistry analysis is a convenient and useful tool that can help to determine the presence of various pathologic conditions in performance horses, including inflammatory conditions of various organ systems, and potentially maladapation to training stress. It achieves its greatest value when combined with careful anamnesis, a thorough physical examination, and additional appropriate diagnostic procedures.…”

Section: Liver Enzymesmentioning

confidence: 99%

Biochemical abnormalities of athletic horses

McKenzie¹

2014

Equine Sports Medicine and Surgery

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Dehydration, electrolyte imbalances and renin‐angiotensin‐aldosterone‐vasopressin axis in successful and unsuccessful endurance horses

Cited by 60 publications

References 22 publications

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

Activation of the renin-angiotensin-aldosterone system in mares around ovulation

A influência da distância na desclassificação de equinos de enduro : alterações hidroeletrolíticas, hemogasométricas e bioquímicas

Biochemical abnormalities of athletic horses

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