Dehydroepiandrosterone Sulfate (DHEAS) Levels in Polycystic Ovarian Syndrome (PCOS)

Khan, Sikandar Hayat; Rizvi, Syeda Arsheen; Shahid, Rahat; Manzoor, Robina

doi:10.29271/jcpsp.2021.03.253

Cited by 14 publications

(7 citation statements)

References 17 publications

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“…10 On the contrary, in a study by Khan et al, it was seen that LH levels and androgen (DHEAS) levels were higher in lean PCOS than in obese. 11 The findings were similar to this study, in which LH levels were higher in lean PCOS women but not statistically significant.…”

Section: Endocrine Profilesupporting

confidence: 88%

Comparison of Endocrine and Metabolic Profile of Obese and Lean PCOS Women with Infertility

Agarwal¹,

Pandey²,

Kumar³

et al. 2022

International Journal of Infertility &Amp; Fetal Medicine

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ReseaRch aRticlecauses of HA, primary hypothalamic amenorrhea, primary ovarian failure, thyroid disease, and prolactin disorder were excluded. The study was ethically conducted in accordance with the Declaration of Helsinki. Ethical approval was obtained prior to the commencement of the study (90th ECM/II B-Thesis/P36).The women enrolled underwent an assessment of height, weight, and BMI. Women were classified into two groups according to BMI group I with BMI <23 kg/m 2 (lean and underweight) and group II with BMI ≥23 kg/m 2 (obese and overweight) according to ICMR guidelines. A detailed menstrual history pattern was taken, and cycles at >35 days interval were classified as oligomenorrhea. These women were compared with reference to waist hip ratio (WHR). Circumference of the waist was measured at the level of the iliac crest after a normal expiration, and hip circumference was taken at the widest point around the buttocks. Abnormal WHC was taken as ≥0.8. Signs of clinical HA like acne, hirsutism, and AN were IntroductIonThe PCOS is the commonest endocrine disorder in reproductive-aged women, with a prevalence of 6-10%. 1 It is a leading cause of infertility and is also associated with an increased risk of metabolic syndrome, diabetes mellitus type II, cardiovascular disease, and endometrial cancer. PCOS affects 30% of infertile women. 1 A majority (60%) of women with PCOS have an above-average or high BMI, insulin resistance (IR), menstrual symptoms, and the typical male pattern of baldness, acne, and hirsutism. Although PCOS is commonly associated with obesity, a lean phenotype also exists.There are different phenotypes of PCOS depending on hyperandrogenism (HA), anovulation, and polycystic morphology on ultrasound. In addition, the pathology of PCOS is related to IR and hyperinsulinemia. Previous studies in India by Majumdar and Singh 2 have shown that IR, acne, and hirsutism are more often seen in obese PCOS and women with hyperandrogenic phenotypes. Lean women with PCOS, on the other hand, have different phenotypic, metabolic, hematologic, and neurologic characteristics than obese participants with PCOS. Therefore, it is hypothesized that obese and lean PCOS women may have different morphology, metabolic, and endocrine characteristics, although they have similar dysfunction. Hence, it is imperative to understand the difference between the two subgroups to plan an appropriate management approach. MaterIals a n d MethodsWomen visiting the infertility clinic in the

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Section: Endocrine Profilesupporting

confidence: 88%

Comparison of Endocrine and Metabolic Profile of Obese and Lean PCOS Women with Infertility

Agarwal¹,

Pandey²,

Kumar³

et al. 2022

International Journal of Infertility &Amp; Fetal Medicine

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“…DHEA is converted into DHEAS in the adrenal cortex and liver. Research has shown that in PCOS, the adrenal gland produces the steroid hormone, DHEA and its derivative DHEAS, which can be converted into more active male hormones such as testosterone, leading to increased androgens (Khan et al, 2021; Luna et al, 2020). Research reported that androgens excess can hinder ovulation in the ovary (Zeng et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa cells of polycystic ovary syndrome

Xuan,

Ren,

et al. 2024

Molecular Reproduction Devel

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Inflammatory damage in ovarian granulosa cells (GCs) is a key mechanism in polycystic ovary syndrome (PCOS), cytoplasmic polyadenylation element binding protein‐1 (CPEB1) is important in inflammatory regulation, however, its role in PCOS is unclear. We aim to research the mechanism of CPEB1 in ovarian GCs in PCOS using dehydroepiandrosterone (DHEA)‐induced PCOS rat models and testosterone‐incubated GC models. The pathophysiology in PCOS rats was analyzed. Quantitative‐realtime‐PCR, TUNEL, immunohistochemistry, and Western blot were applied for quantification. Additionally, cell counting kit‐8, flow cytometry, immunofluorescence, Western blot, and Monodansylcadaverine staining were performed. We found that PCOS rat models exhibited a disrupted estrus cycle, elevated serum levels of testosterone, luteinizing hormone (LH), and follicle‐stimulating hormone (FSH), increased LH/FSH ratio, and heightened ovarian index. Furthermore, reduced corpus luteum and increased follicular cysts were observed in ovarian tissue. In ovarian tissue, autophagy and apoptosis were activated and CPEB1 was overexpressed. In vitro, CPEB1 overexpression inhibited cell viability and sirtuin‐1 (SIRT1), activated tumor necrosis factor‐α, and interleukin‐6 levels, as well as apoptosis and autophagy; however, CPEB1 knockdown had the opposite effect. In conclusion, overexpression of CPEB1 activated autophagy and apoptosis of ovarian GCs in PCOS.

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“…In a study on the fecal metabolites and gut microbiota in obese patients with PCOS, several fecal metabolites were used as characteristic metabolites, including DHEAS, which was significantly and positively correlated with the serum testosterone level and negatively correlated with body mass index (BMI) or fasting insulin among PCOS patients [ 26 , 55 ]. DHEAS is a kind of androgen mainly secreted by the adrenal cortex, and found to be high in 22–25% of patients with PCOS [ 56 ]. Higher DHEAS could increase incidence of degenerated oocytes and early miscarriage rates in women with PCOS [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet

et al. 2023

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Background This study aimed to compare the characteristics of the gut microbiota and their metabolite profiles between polycystic ovary syndrome (PCOS) and orlistat-treated PCOS rats (ORL-PCOS), which could help to better understand the underlying mechanism of the effect of orlistat on PCOS. Methods PCOS rat models were established using letrozole combined with a high-fat diet. Ten rats were randomly selected as a PCOS control group (PCOS). The other three groups (n = 10/group) were additionally supplemented with different doses of orlistat (low, medium, high). Then, fecal samples of the PCOS and ORL-PCOS groups were analysed by 16S rRNA gene sequencing and untargeted metabolomics. Blood samples were collected to detect serum sex hormones and lipids. Results The results showed that orlistat attenuated the body weight gain, decreased the levels of T, LH, the LH/FSH ratio, TC, TG and LDL-C; increased the level of E2; and improved estrous cycle disorder in PCOS rats. The bacterial richness and diversity of the gut microbiota in the ORL-PCOS group were higher than those in the PCOS group. The ratio of Firmicutes to Bacteroidetes was decreased with orlistat treatment. Moreover, orlistat treatment led to a significant decrease in the relative abundance of Ruminococcaceae and Lactobacillaceae, and increases in the abundances of Muribaculaceae and Bacteroidaceae. Metabolic analysis identified 216 differential fecal metabolites in total and 6 enriched KEGG pathways between the two groups, including steroid hormone biosynthesis, neuroactive ligand-receptor interaction and vitamin digestion and absorption. Steroid hormone biosynthesis was the pathway with the most significant enrichment. The correlations between the gut microbiota and differential metabolites were calculated, which may provide a basis for understanding the composition and function of microbial communities. Conclusions Our data suggested that orlistat exerts a PCOS treatment effect, which may be mediated by modifying the structure and composition of the gut microbiota, as well as the metabolite profiles of PCOS rats.

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Dehydroepiandrosterone Sulfate (DHEAS) Levels in Polycystic Ovarian Syndrome (PCOS)

Abstract: Objective: To compare DHEAS levels among subjects with and without PCOS, evaluating differences between lean-PCOS or obese-PCOS phenotype for insulin resistance, anthropometric indices, glycemic and lipid parameters. Study Design: Descriptive study.

Cited by 14 publications

References 17 publications

Comparison of Endocrine and Metabolic Profile of Obese and Lean PCOS Women with Infertility

Comparison of Endocrine and Metabolic Profile of Obese and Lean PCOS Women with Infertility

CPEB1 induces autophagy and promotes apoptosis in ovarian granulosa cells of polycystic ovary syndrome

Integrated fecal microbiota and metabolomics analysis of the orlistat intervention effect on polycystic ovary syndrome rats induced by letrozole combined with a high-fat diet

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