Dehydroepiandrosterone up-regulates resistin gene expression in white adipose tissue

Kochan, Zdzisław; Karbowska, Joanna

doi:10.1016/j.mce.2003.12.012

Cited by 44 publications

(30 citation statements)

References 36 publications

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“…DHEA is also involved in lipid metabolism, showing protective effects against visceral fat accumulation and muscle insulin resistance development (Hansen et al 1997) and, likely, it exerts its fat-reducing effects by increasing peroxisome proliferator-activated receptor-a (PPARa) gene expression and consequently inducing the expression of enzymes involved in fatty acid catabolism (Kochan & Karbowska 2004).…”

Section: Introductionmentioning

confidence: 99%

Dehydroepiandrosterone secretion in dairy cattle is episodic and unaffected by ACTH stimulation

Marinelli

Trevisi

Dalt

et al. 2007

Journal of Endocrinology

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This paper describes the episodic release and response to adrenal stimulation of cortisol and dehydroepiandrosterone (DHEA) in cows. Observations made in samples taken every 10 min for 8 h (experiment 1) showed that plasma DHEA was significantly greater (P!0 . 001) than DHEA-S, and release of these steroids was episodic and variable between animals (P!0 . 01). No relationship was found between DHEA and cortisol. Significant (P!0 . 001) DHEA-sulphate (DHEA-S) versus cortisol (RZK0 . 264) and DHEA-S versus DHEA (RZ0 . 200) correlations were found. DHEA and DHEA-S were not affected by a single ACTH challenge (experiment 2). In experiment 3, cortisol and DHEA secretions in response to prolonged ACTH administration (every 12 h for 6 days) were studied. On day 7, the episodic cortisol and DHEA release and response to the opioid antagonist naloxone were studied in blood samples taken every 10 min for 8 h. Animals were injected with naloxone after 4 h. A significant increase (P!0 . 05) in mean circulating DHEA and DHEA pulse amplitude was observed during frequent sampling following ACTH treatment. DHEA and DHEA-S plasma concentrations were not affected following luteal regression (experiment 4). The effect of milk secretion around parturition on DHEA secretion was studied in dry and continuously milked cows (experiment 5). Plasma DHEA was significantly lower (P!0 . 05) in milked cows. In the cow, ACTH is not an important DHEA secretagogue. Adrenal contribution to plasma DHEA is scarce. Likely, the placenta is the most important source of DHEA, and the lactating mammary gland can affect circulating DHEA levels. Investigation about the DHEA biological role in cows should be focused around parturition.

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Section: Introductionmentioning

confidence: 99%

Dehydroepiandrosterone secretion in dairy cattle is episodic and unaffected by ACTH stimulation

Marinelli

Trevisi

Dalt

et al. 2007

Journal of Endocrinology

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“…These results have prompted a focus on gene expression in the liver, particularly those genes that are involved in fatty acid synthesis and secretion [18,19], including SREBP-1c, ACC, PPARa, CPTI and ACOX1. In contrast to the large number of studies on these liver metabolic parameters and lipogenic gene mRNA expression variances induced by DHEA in mice, rats and humans [20,21], little is known about the effect of DHEA on hepatic lipid metabolism in poultry, and especially in broiler chickens.…”

Section: Introductionmentioning

confidence: 99%

Effects of Dehydroepiandrosterone (DHEA) on Hepatic Lipid Metabolism Parameters and Lipogenic Gene mRNA Expression in Broiler Chickens

Tang

Zou

2007

Lipids

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The aim of the present study was to identify the effects of dehydroepiandrosterone (DHEA) on hepatic lipid metabolism parameters and lipogenic gene mRNA expression in broiler chickens. A total of 72 1-day-old broiler chicks received a common basal diet with DHEA added at either 0 (control), 5 or 20 mg/kg feed. In the present study, the hepatic triglyceride (TG) concentration was significantly lower in male and female broilers that had bed administered DHEA than in control birds. In contrast, DHEA administration caused a marked rise in the hepatic non-esterified fatty acid (NEFA) concentration in both male and female broilers and also increased lipase (HL) activity in male broilers, while in female birds, no significant differences were observed in HL activity. The expression of peroxisome proliferators-activated receptor alpha (PPARalpha) and carnitine palmitoyl transferase I (CPTI) mRNA was decidedly enhanced following treatment with DHEA, and a similar tendency was also observed in the expression of acyl-Coenzyme A oxidase 1 (ACOX1). However, no significant differences were observed in the expression of either sterol regulatory element binding protein-1c (SREBP-1c) or acetyl CoA carboxylase (ACC) mRNA, except for a decline in the expression of ACC in females treated with 5 mg DHEA/kg. Numerous peroxisomes without a core and an increased number of peroxisomes were evident during morphological observations of broiler livers, in animals that had been treated with DHEA. Overall, the results of the present study indicated that DHEA accelerated lipid catabolism by direct regulation of hepatic lipid metabolism and by induction of relevant gene expression.

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“…PRT is known to exert an anti-NF-B effect by inactivating inhibitory kB (IkB) kinase (Kwok et al 2001). DHEA, in contrast, may inhibit NF-B through its antioxidant effect by altering the intracellular redox state (Gao et al 2005, Kabe et al 2005, through inhibition of I B ubiquitination is shown in diabetic rats (Aragno et al 2002), or through activation of PPAR (Kochan & Karbowska 2004). Thus, we assume that the combined effects of the two drugs are caused, at least partly, by their inhibitory effects on NF-B function, although the effects on other signaling pathway(s) are not ruled out.…”

Section: Discussionmentioning

confidence: 96%

Suppressive effects of dehydroepiandrosterone and the nuclear factor-κB inhibitor parthenolide on corticotroph tumor cell growth and function in vitro and in vivo

Taguchi¹,

Takao²,

Iwasaki³

et al. 2006

Journal of Endocrinology

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Dehydroepiandrosterone (DHEA) is believed to have an anti-tumor effect, as well as anti-inflammatory, antioxidant, and anti-aging effects. To clarify the possible inhibitory action of DHEA on pituitary tumor cells, we tested the effects of DHEA, alone or in combination with the nuclear factor-B (NF-B) inhibitor parthenolide (PRT), on AtT20 corticotroph cell growth and function both in vitro and in vivo. We found that, in vitro, DHEA and PRT had potent inhibitory effects on pro-opiomelanocortin and NF-B-dependent gene expression. They also suppressed the transcription activity of survivin, a representative anti-apoptotic factor, and induced apoptosis in this cell line. Furthermore, using BALB/C nude mice with xenografts of AtT20 cells in vivo, we found that the combined administration of DHEA and PRT significantly attenuated tumor growth and survivin expression. The treatment also decreased the elevated plasma corticosterone levels and ameliorated the malnutrition induced by tumor growth. Altogether, these results suggested that combined treatments of DHEA and PRT potently inhibit the growth and function of corticotroph tumor cells both in vitro and in vivo. This effect may, at least partly, be caused by the suppressive effects of these compounds, such as survivin and other inhibitor of apoptosis proteins, on NF-B-mediated gene transcription.

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Dehydroepiandrosterone up-regulates resistin gene expression in white adipose tissue

Cited by 44 publications

References 36 publications

Dehydroepiandrosterone secretion in dairy cattle is episodic and unaffected by ACTH stimulation

Dehydroepiandrosterone secretion in dairy cattle is episodic and unaffected by ACTH stimulation

Effects of Dehydroepiandrosterone (DHEA) on Hepatic Lipid Metabolism Parameters and Lipogenic Gene mRNA Expression in Broiler Chickens

Suppressive effects of dehydroepiandrosterone and the nuclear factor-κB inhibitor parthenolide on corticotroph tumor cell growth and function in vitro and in vivo

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