Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats

Peng, Jun-Hua; Zhang, Change; Wei, Wei; Hong, Xiaoping; Pan, Xiping; Wang, Jian‐Zhi

doi:10.1016/j.neuropharm.2007.02.008

Cited by 41 publications

(35 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many sites of tau phosphorylation are serine or threonine residues that are immediately followed in the sequence by Proline residues, and hence are candidate phosphorylation sites for Proline-directed kinases [129,130]. GSK-3 plays a central role in AD, which is involved in the hyperphosphorylation of tau [131,132] Fig.…”

Section: Gsk-3 Directly Phosphorylates Taumentioning

confidence: 99%

Roles of Glycogen Synthase Kinase 3 in Alzheimer’s Disease

Cai

Zhao

2012

CAR

113

View full text Add to dashboard Cite

Evidence from basic molecular biology has noted a critical role of GSK-3 in Alzheimer's disease (AD) pathogenesis such as beta-amyloid (Aβ) production and accumulation, the formation of neurofibrillary tangle (NFT), and neuronal degeneration. Aβ generation and deposition represents a key feature and is generated from APP by the sequential actions of two proteolytic enzymes: β-secretase and γ-secretase. GSK-3 could play a critical role in Aβ production via enhancing β-secretase activity. GSK-3 not only modulates APP processing in the process of Aβ generation, but regulates Aβ production by interfering with APP cleavage at the γ-secretase complex step since the APP and PS1 (a component of γ- secretase complex) are substrates of GSK-3 as well. GSK-3 may downregulate α-secretase through inhibiting PKC and ADAMs activity which are the substrates of GSK-3 contributing to Aβ production. Meanwhile, Aβ accumulation can induce GSK-3 activation through Aβ-mediated neuroinflammation and oxidative stress. Considering that active GSK-3 and some common GSK-3-shared factors induce the hyperphosphorylation of tau and neurofibrillary lesions, GSK-3 is a possible linking between amyloid plaques and NFT pathology. Additionally, GSK-3 could disrupt acetylcholine activity, and accelerate axon degeneration and failures in axonal transport, and lead to cognitive impairment in AD. Preclinical and clinical studies have supported that GSK-3β inhibitors could be useful in the treatment of AD. Consequently, an effective measure to inhibit GSK-3 activity may be a very attractive drug target in AD.

show abstract

Section: Gsk-3 Directly Phosphorylates Taumentioning

confidence: 99%

Roles of Glycogen Synthase Kinase 3 in Alzheimer’s Disease

Cai

Zhao

2012

CAR

113

View full text Add to dashboard Cite

show abstract

“…Our study reported that DeHE pretreatment attenuated intracerebroventricular administration of beta-amyloid peptide (25-35) and intraperitoneal administration of scopolamine induced amnesia in mice [62]. Furthermore, pre-administration of DeHE via vena caudalis for one week effectively improved the Wortmannin and GF-109 203X (WT/GFX) induced spatial memory retention impairment of rats, antagonized tau hyperphosphorylation at multiple Alzheimer's disease site and arrested the overactivation of glycogen synthase kinase-3 induced by WT/GFX [63]. DeHE did not cause any serious adverse effects at the dose levels in the experimental animals [64].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components

Liao¹,

Chiou

Shen

et al. 2011

Chin Med

View full text Add to dashboard Cite

This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia-inducible factor 1 alpha, reactive oxygen species, prostaglandins, tumor necrosis factor, LIGHT, amyloid protein and orexigenic neuropeptides. Their potential applications for the treatment of endotoxaemia, obesity, diabetes, Alzheimer's disease and their uses as cardiovascular and gastrointestinal protective agents, analgesics, anti-oxidant, anti-atherosclerosis agents, dermatological agents and anti-infectious agents are highlighted. Stimulation of calcitonin gene-related peptide release may partially explain the analgesic, cardiovascular and gastrointestinal protective, anti-obese activities of Evodia rutaecarpa and its major bioactive components.

show abstract

“…It could also protect against learning and memory impairment in both scopolamine-and Ab-induced amnesia animal. The mechanism of the neuroprotective effects of dehyroevodiamine has been examined by Peng et al [17,18].…”

Section: Resultsmentioning

confidence: 99%

Melanogenesis inhibitory effect of dehydroevodiamine isolated from fruits of Evodia rutaecarpa

Luo

Seo

Nguyen

et al. 2010

Korean J. Chem. Eng.

View full text Add to dashboard Cite

Dehydroevodiamine, an alkaloid, was isolated from the fruit of Evodia rutaecarpa and melanin production, and tyrosinase inhibition in B16F10 melanoma cells treated with the isolated dehydroevodiamine was investigated. The compound decreased melanin synthesis significantly without promoting cytotoxicity. The IC 50 value of dehydroevodiamine for melanogenesis and cell viability were 59.8 µM and 90.0 µM, respectively. The L-dopa oxidase activity of mushroom tyrosinase was reduced after dehydroevodiamine treatment by about 22.4% at a concentration of 33.2 µM. However, there was no effect on cellular tyrosinase activity. These results indicate that the observed decrease in melanin content after treatment with dehydroevodiamine was attributed to the direct inhibition of tyrosinase activity, rather than the suppression of tyrosinase gene expression. Dehydroevodiamine may be a promising new agent for use in cosmeceutical application.

show abstract

Dehydroevodiamine attenuates tau hyperphosphorylation and spatial memory deficit induced by activation of glycogen synthase kinase-3 in rats

Cited by 41 publications

References 36 publications

Roles of Glycogen Synthase Kinase 3 in Alzheimer’s Disease

Roles of Glycogen Synthase Kinase 3 in Alzheimer’s Disease

Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components

Melanogenesis inhibitory effect of dehydroevodiamine isolated from fruits of Evodia rutaecarpa

Contact Info

Product

Resources

About