Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components

Liao, Jyh‐Fei; Chiou, Wen-Fei; Shen, Yung Kang; Wang, Guei-Jane; Chen, Chieh-Fu

doi:10.1186/1749-8546-6-6

Cited by 82 publications

(46 citation statements)

References 94 publications

(97 reference statements)

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“…Fifteen microliter (15 μl) reaction containing 0.5 μl single-strand cDNA, 7.5 μl Master Mix, 1 μl of the each forward and reverse primers (5 pmol/μl) and 5 μl dH 2 O. The primers forABCG5 and β-actin (as normalizer) were taken from Hongwei et al, 2003 and Gao &Yuan, 2010, respectively) (Table 1) (34, 35). Real-time PCR reactions were performed using the Rotor Gene 3000 real time PCR system from Corbett using following program: step1: 95°C for 5 min and step 2: 40 cycle of 95°C for 10 sec and 60°C for 30 sec.…”

Section: Methodsmentioning

confidence: 99%

ABCG8 Gene Responses to 8 Weeks Treadmill Running With or Without Pistachia atlantica (Baneh) Extraction in Female Rats

Ghanbari–Niaki¹,

Rahmati-Ahmadabad²,

Kookandeh³

2012

Int J Endocrinol Metab

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BackgroundIt is well established that the excess cellular cholesterol concentration, as well as high density lipoprotein (HDL) and total cholesterol levels are strongly correlated with the incidence of coronary artery disease (CAD). Reverse cholesterol transport (RCT) is a term used to describe the efflux of excess cellular cholesterol. ABCG8 is a member of ABCG family that play a critical role in this process.ObjectivesThe current study was conducted to investigate the effect of endurance exercise with or without Pistachia atlantica (Baneh) extraction on small intestine and kidney ABCG8 gene, also plasma high density lipoprotein (HDL-c), triglyceride (TG), total cholesterol (TC), glucose, and estrogen levels in female rats.Materials and MethodsIn this study twenty Wistar female rats (six to eight weeks old, 125-135 g weight) were used. Animals were randomly assigned into training (n = 10) and control (n = 10) groups and further divided into saline-control (SC), saline-training (ST), Baneh-control (BC), and Baneh-training (BT) groups. Training groups was given exercise on a motor-driven treadmill at 25 m/min (0% grade) for 60 min/day, 5 days/week for eight weeks. Animals were fed orally with Baneh extraction and saline for four week. After the last training session, rats were sacrificed, small intestine and kidney were excised, and ABCG8 expression was detected by Real-time PCR method. Plasma also was collected for plasma variable measurements. Statistical analysis was performed using a one way analysis of variance, and significance was accepted at P < 0.05. Correlation was calculated using the Pearson Product Moment correlation.ResultsExercise increased (P < 0.01) and Baneh reduced intestinal ABCG8 mRNA (P < 0.05). In kidney tissue, there wasn’t significant change between the groups (P < 0.40). Plasma HDL-C level was increased by exercise (P < 0.05) and decreased by Baneh (P < 0.02) that was correlated by intestine ABCG8 (r = 0.81, P < 0.001). Plasma TG and TC were unchanged, but glucose and estradiol were increased and decreased in Baneh groups (P < 0.02), respectively.ConclusionsOur study shows that exercise increases intestinal ABCG8 mRNA, and Baneh can increase plasma glucose concentration and reduce ABCG8 expression, HDL-C, and estrogen levels probably due to high fatty acid components.

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Section: Methodsmentioning

confidence: 99%

ABCG8 Gene Responses to 8 Weeks Treadmill Running With or Without Pistachia atlantica (Baneh) Extraction in Female Rats

Ghanbari–Niaki¹,

Rahmati-Ahmadabad²,

Kookandeh³

2012

Int J Endocrinol Metab

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“…Aldose reductase inhibitors have considerable potential in treatment of diabetic complications, without increased risk of hypoglycemia (Kato et al, 2009). Evodiamine improved glucose tolerance and prevented the progress of insulin resistance associated with obese/diabetic states through inhibition of mTOR-S6K signaling and IRS1 serine phosphorylation in adipocytes (Liao et al, 2011;Wang et al, 2013). Rutaecarpine, an indolopyridoquinazoline alkaloid, isolated from E. rutaecarpa showed potential effects on diabetic metabolic syndrome (Jia and Hu, 2010).…”

Section: Introductionmentioning

confidence: 99%

O-prenylated flavonoid, an antidiabetes constituent in Melicope lunu-ankenda

George

Nair

Johnson

et al. 2015

Journal of Ethnopharmacology

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“…Evodiamine and rutaecarpine are the primary bioactive ingredients in E. rutaecarpa , and were designated as the biomarkers for quality evaluation of this herb medicine (Chinese Pharmacopoeia Committee, ). It has been found that evodiamine has anti‐inflammatory (Liao, Chiou, Shen, Wang, & Chen, ), anti‐obesity (Kobayashi et al, ) and vasodilatory effects (Chiou, Liao, & Chen, ). Recent studies have proved that evodiamine shows cytotoxicity on various human cancer cell lines (Adams et al, ; Liao et al, ; Xu et al, ).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of evodiamine and its four metabolites in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

Wang¹,

Fang²,

Ai³

et al. 2018

Biomedical Chromatography

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A simple and sensitive liquid chromatography tandem mass spectrometry method was validated for simultaneous quantification of evodiamine and its metabolites 10-hydroxyevodiamine (M1), 18-hydroxyevodiamine (M2), 10-hydroxyevodiamine-glucuronide (M3) and 18-hydroxy- evodiamine-glucuronide (M4) in rat plasma for the first time. The analytes were extracted with acetonitrile and separated on a C column within 3 min. The detection was achieved in positive selected reaction monitoring mode with precursor-to-product transitions at m/z 304.1 → 161.1 for evodiamine, m/z 320.1 → 134.1 for M1, m/z 320.1 → 150.1 for M2, m/z 496.2 → 134.1 for M3, m/z 496.2 → 171.1 for M4 and m/z 349.2 → 305.1 for camptothecin (internal standard). The linearity was evident over the tested concentration ranges with correlation coefficients >0.9991. The lower limits of quantification for evodiamine, M1, M2, M3 and M4 were 0.1, 0.1, 0.1, 0.25 and 0.25 ng mL , respectively. Extraction recoveries and matrix effects of the analytes were within the ranges of 84.51-97.21 and 90.13-103.30%, respectively. The accuracy (relative error) ranged from -8.14 to 7.23% while the intra- and inter-day precisions (relative standard deviation) were < 9.31%. The validated assay was successfully applied for the pharmacokinetic study of evodiamine, M1, M2, M3 and M4 in rat. The current study will be helpful in understanding the in vivo disposition of evodiamine.

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Anti-inflammatory and anti-infectious effects of Evodia rutaecarpa (Wuzhuyu) and its major bioactive components

Cited by 82 publications

References 94 publications

ABCG8 Gene Responses to 8 Weeks Treadmill Running With or Without Pistachia atlantica (Baneh) Extraction in Female Rats

ABCG8 Gene Responses to 8 Weeks Treadmill Running With or Without Pistachia atlantica (Baneh) Extraction in Female Rats

O-prenylated flavonoid, an antidiabetes constituent in Melicope lunu-ankenda

Simultaneous determination of evodiamine and its four metabolites in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

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