O-prenylated flavonoid, an antidiabetes constituent in Melicope lunu-ankenda

George, Sony; Nair, S. Ajikumaran; Johnson, Anil John; Venkataraman, Ramesh; Baby, Sabulal

doi:10.1016/j.jep.2015.03.060

Cited by 18 publications

(14 citation statements)

References 32 publications

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“…Results of the study were in agreement with those of previous study, where hamsters rats fed with high-fat diet following treatment of Schisandrachinensis fruit (SF) extract showed significant reduction in their serum levels of TC, TG, LDL and enhancement in HDL level [28]. Similar results have also been reported in another study, where diabetic rats treated with O-prenylated flavonoid (3,5,40-trihydroxy-8,30-dimethoxy-7-(3-methylbut-2-enoxy)flavone;OPF) isolated from Melicope lunu-ankenda leaves showed decrease in serum TC and TG levels, with increased levels of HDL [29]. The observed reduction in the elevated serum TC, TG, and LDL levels and augmentation in HDL level of obese diabetic rats fed with ML extract might be related to the enhanced insulin secretion by the pancreatic β-cells, which is an indicator of lipid metabolism and utilization.…”

Section: Discussionsupporting

confidence: 78%

“…However, the liver weights of ML extract treated rats were significantly decreased as compared with those of untreated obese diabetic rats, to the levels almost equivalent to the healthy rats. In a previous study, diabetic rats treated with OPF isolated from Melicope lunu-ankenda leaves also restored the liver weights to the normal levels [29]. In addition, the treatment of obese diabetic rats with ML leaf extract decreased the weight of kidney (Table 2) after 8 weeks of treatment.…”

Section: Discussionmentioning

confidence: 70%

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Biochemical characterization and 1H NMR based metabolomics revealed Melicope lunu-ankenda leaf extract a potent anti-diabetic agent in rats

AL-Zuaidy

Mumtaz

Hamid

et al. 2017

BMC Complement Altern Med

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BackgroundType 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by continuous hyperglycemia associated with insulin resistance and /or reduced insulin secretion. There is an emerging trend regarding the use of medicinal plants for the treatment of diabetes mellitus. Melicope lunu-ankenda (ML) is one of the Melicope species belonging to the family Rutaceae. In traditional medicines, its leaves and flowers are known to exhibit prodigious health benefits. The present study aimed at investigating anti-diabetic effect of Melicope lunu-ankenda (ML) leaves extract.MethodsIn this study, anti-diabetic effect of ML extract is investigated in vivo to evaluate the biochemical changes, potential serum biomarkers and alterations in metabolic pathways pertaining to the treatment of HFD/STZ induced diabetic rats with ML extract using 1H NMR based metabolomics approach. Type 2 diabetic rats were treated with different doses (200 and 400 mg/kg BW) of Melicope lunu-ankenda leaf extract for 8 weeks, and serum samples were examined for clinical biochemistry. The metabolomics study of serum was also carried out using 1H NMR spectroscopy in combination with multivariate data analysis to explore differentiating serum metabolites and altered metabolic pathways.ResultsThe ML leaf extract (400 mg/kg BW) treatment significantly increased insulin level and insulin sensitivity of obese diabetic rats, with concomitant decrease in glucose level and insulin resistance. Significant reduction in total triglyceride, cholesterol and low density lipoprotein was also observed after treatment. Interestingly, there was a significant increase in high density lipoprotein of the treated rats. A decrease in renal injury markers and activities of liver enzymes was also observed. Moreover, metabolomics studies clearly demonstrated that, ML extract significantly ameliorated the disturbance in glucose metabolism, tricarboxylic acid cycle, lipid metabolism, and amino acid metabolism.ConclusionML leaf extract exhibits potent antidiabetic properties, hence could be a useful and affordable alternative option for the management of T2DM.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 70%

Biochemical characterization and 1H NMR based metabolomics revealed Melicope lunu-ankenda leaf extract a potent anti-diabetic agent in rats

AL-Zuaidy

Mumtaz

Hamid

et al. 2017

BMC Complement Altern Med

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“…In Malaysia, M. lunu-ankenda is locally known as “tenggek burung” [ 18 ]. The leaves are consumed as salad and condiment for food flavoring, as well as traditionally used to revitalize the body [ 19 , 20 , 21 ].…”

Section: Melicope In Folk Usagementioning

confidence: 99%

“…In India, different parts of the plant are used for treatment for fever, the improvement of complexion, and as an emmenagogue and tonic. The leaves are utilized for the treatment for diabetes in folklore medicinal practices [ 18 ]. In Eastern Ghats, one of the nine Floristic Zones in India, the decocted root is used to treat asthma and bronchitis by mixing with black pepper and salt [ 22 ].…”

Section: Melicope In Folk Usagementioning

confidence: 99%

Phytochemical Constituents and Biological Activities of Melicope lunu-ankenda

Eliaser

Hashim

et al. 2018

Molecules

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Natural products, either pure compounds or standardized plant extracts, have provided opportunities for the discovery of new drugs. Nowadays, most of the world’s population still relies on traditional medicines for healthcare purposes. Plants, in particular, are always used as traditional medicine, as they contain a diverse number of phytochemicals that can be used for the treatment of diseases. The multicomponent feature in the plants is considered a positive phytotherapeutic hallmark. Hence, ethnopharmacognosy has been the focus for finding alternative treatments for diseases. Melicope lunu-ankenda, also known as Euodia lunu-ankenda, is widely distributed in tropical regions of Asia. Different parts of M. lunu-ankenda have been used for treatment of hypertension, menstrual disorder, diabetes, and fever, and as an emmenagogue and tonic. It has also been consumed as salad and as a condiment for food flavorings. The justification of use of M. lunu-ankenda in folk medicines is supported by its reported biological activities, including its cytotoxic, antibacterial, antioxidant, analgesic, antidiabetic, and anti-inflammatory activities. This review summarizes the phytochemical compounds isolated from various parts of M. lunu-ankenda, such as root and leaves, and also its biological activities, which could make the species a new therapeutic agent for some diseases, including diabetes, in the future.

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“…2 Treatment with O-prenilated flavonoid constituents in Melicope lunu-ankenda at dose 10mg/kg BW given to diabetic rats significantly reduced blood glucose levels after 2 weeks returning it very close to normal values. 3 Jiang et al 4 treated diabetic rats with fenugreek flavonoids at dose 0.5 g in 10 mL water intragastrically for 28 days and found significantly decreased levels of fasting blood glucose (FBG).…”

Section: Introductionmentioning

confidence: 99%

The role of isoflavon in reducing blood glucose levels

Prasetyastuti

2018

JMedScie

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Plants provide excellent sources of medicinal compounds. Over 5000 flavonoids have been isolated and identified from plant sources. Flavonoids are polyphenolic compounds mainly recognized as pigments which produce the colors found in flowers, fruit and leaves. Dietary polyphenols are commonly found in plants and are abundant in fruit, vegetables, chocolate, and nuts. These polyphenols also found in beverages including tea, coffee, wine, and soy milk. Flavonoids are known to lower glucose levels, decrease cholesterol and triglycerides, and increase liver enzyme levels most likely by stimulating pancreatic insulin release. By activating cell-signaling pathways involved in controlling blood glucose levels, flavonoids aid in carbohydrate digestion, and adipose deposition. Flavonoids containing isoflavones, flavanols, flavanones, flavonols, flavones, and anthocyanins have been studied from clinic study until pre clinic study. However, not all of the studies conducted had adequate results. Isoflavone is one of the potential flavonoids that still can be explored for future research. Research on isoflavone supplementation in animals and humans in reducing blood glucose levels is still limited. Short-term supplementation did not improve blood glucose levels in postmenopausal women, while other studies suggest that the long-term isoflavone supplementation can reduce postmenopausal blood glucose levels. These findings found that isoflavone is a component of flavonoids that have potency in reducing blood glucose levels. ABSTRAK Tanaman merupakan sumber senyawa obat yang bagus. Lebih dari 5000 flavonoid telah di isolasi dan di identifikasi dari tumbuhan. Flavonoid merupakan senyawa polifenol terutama dikenal sebagai pigmen yang bertanggung jawab terhadap beberapa warna bunga, buah dan daun. Polifenol diet merupakan senyawa kimia yang berasal dari tumbuhan yang banyak terdapat dalam buah, sayuran, coklat, dan kacang, juga terdapat pada minuman seperti teh, kopi, anggur dan susu kedelai. Flavonoid dapat menurunkan kadar glukosa darah, kolesterol dan trigliserida plasma secara bermakna dan meningkatkan aktivitas glukokinase hepar dengan meningkatkan pelepasan insulin dari sel beta pankreas. Flavonoid mengatur pencernaan karbohidrat, deposisi jaringan adiposa, pelepasan insulin, dan ambilan glukosa dalam jaringan yang merespon terhadap insulin melalui beberapa jalur signaling sel. Flavonoid terdiri dari isoflavon, flavanol, flavanon, flavonol, flavon, dan antosiani telah dikaji mulai dari uji pre klinik sampai klinik. Namun, tidak semua penelitian yang dilakukan menunjukkan hasil yang sesuai. Salah satu flavonoid yang mungkin memberi harapan untuk penelitian masa depan adalah isoflavon. Penelitian tentang suplementasi isoflavon pada hewan dan manusia dalam menurunkan kadar glukosa darah masih terbatas. Suplementasi isoflavon jangka pendek tidak memperbaiki kadar glukosa darah pada wanita postmenopausal, sedangkan penelitian lain menunjukkan bahwa suplementasi isoflavon jangka panjang dapat menurunkan kadar glukosa darah wanita po...

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O-prenylated flavonoid, an antidiabetes constituent in Melicope lunu-ankenda

Cited by 18 publications

References 32 publications

Biochemical characterization and 1H NMR based metabolomics revealed Melicope lunu-ankenda leaf extract a potent anti-diabetic agent in rats

Biochemical characterization and 1H NMR based metabolomics revealed Melicope lunu-ankenda leaf extract a potent anti-diabetic agent in rats

Phytochemical Constituents and Biological Activities of Melicope lunu-ankenda

The role of isoflavon in reducing blood glucose levels

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