Delay aversion but preference for large and rare rewards in two choice tasks: implications for the measurement of self-control parameters

Adriani, Walter; Laviola, Giovanni

doi:10.1186/1471-2202-7-52

Cited by 61 publications

(53 citation statements)

References 46 publications

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“…However, there is evidence that these types of decisions may, in fact, be dissociable. Intact rats differentially alter their preference for larger rewards associated with increasing delays or risk (Adriani and Laviola, 2006). After extended training, rats shift to choosing a small/immediate reward vs a larger/ delayed reward as the delay increases.…”

Section: Mechanisms Underlying Changes In Risky Choice Induced By Da mentioning

confidence: 99%

Dopaminergic Modulation of Risk-Based Decision Making

Onge

Floresco

2008

Neuropsychopharmacol

306

299

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Psychopharmacological studies have implicated the mesolimbic dopamine (DA) system in the mediation of cost/benefit evaluations about delay or effort-related costs associated with larger rewards. However, the role of DA in risk-based decision making remains relatively unexplored. The present study investigated the effects of systemic manipulations of DA transmission on risky choice using a probabilistic discounting task. Over discrete trials, rats chose between two levers; a press on the 'small/certain' lever always delivered one reward pellet, whereas a press on the other, 'large/risky' lever delivered four pellets, but the probability of receiving reward decreased across the four trial blocks (100, 50, 25, 12.5%). In separate groups of well-trained rats we assessed the effects of the DA releaser amphetamine, as well as receptor selective agonists and antagonists. Amphetamine consistently increased preference for the large/risky lever; an effect that was blocked or attenuated by co-administration of either D 1 (SCH23390) or D 2 (eticlopride) receptor antagonists. Blockade of either of these receptors alone induced risk aversion. Conversely, stimulation of D 1 (SKF81297) or D 2 (bromocriptine) receptors also increased risky choice. In contrast, activation of D 3 receptors with PD128,907 reduced choice of the large/risky lever. Likewise, D 3 antagonism with nafadotride potentiated the amphetamine-induced increase in risky choice. Blockade or stimulation of D 4 receptors did not reliably alter behavior. These findings indicate that DA has a critical role in mediating risk-based decision making, with increased activation of D 1 and D 2 receptors biasing choice toward larger, probabilistic rewards, whereas D 3 receptors appear to exert opposing effects on this form of decision making.

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Section: Mechanisms Underlying Changes In Risky Choice Induced By Da mentioning

confidence: 99%

Dopaminergic Modulation of Risk-Based Decision Making

Onge

Floresco

2008

Neuropsychopharmacol

306

299

View full text Add to dashboard Cite

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“…However, recent studies have cast a doubt on the hypothetical equivalence of a decrease in probability to an increase in delay; specifically, several studies reported that parameters in delay and probability discounting functions are not so strongly correlated as originally supposed [13,20], and some studies have reported that neurobiological/psychopharmacological manipulation distinctly impacts delay and probability discounting [3,21]. Additionally, a recent study by Bickel's group has proposed an analytical strategy combining delay and probability [22].…”

Section: Introductionmentioning

confidence: 99%

Comparison of probabilistic choice models in humans

2007

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“…standing over the partner lying with its back on the floor. Laviola, 2006). Hence, animals had to make a choice between a small/sure (SS) or a large/luck-linked (LLL) reward (session length 25 min ; timeout 15 s ; see Supplementary Material for more details).…”

Section: Expt 1 : Social-interaction Testmentioning

confidence: 99%

“…Rats underwent a Probabilistic-delivery operant task, specifically tailored to induce a kind of 'temptation ' to gamble on the possibility of a rare but bigger prize over the certainty of a lower one (Adriani & Laviola, 2006). Control and Sil rats shifted to the latter option, as expected (Adriani et al 2009).…”

Section: Repertoire Of Gambling-like Traitsmentioning

confidence: 99%

Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens

Adriani

Boyer

Leo

et al. 2010

International Journal of Neuropsychopharmacology

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Dysfunction of brain dopamine transporter (DAT) has been associated with sensation seeking and impulse-control disorders. We recently generated a new animal model by stereotaxical inoculation of lentiviral vectors, which allowed localized intra-accumbal delivery of modulators for DAT gene: GFP (green fluorescent protein) control, silencers (Sil), a regulatable enhancer (DAT+), or both (DAT+Sil). Wistar male rats were followed both for socio-emotional profiles and for propensity to seek risky, uncertain rewards. Elevated anxiety and affiliation towards an unfamiliar partner emerged in Sil rats. Interestingly, in DAT+Sil rats (and Sil rats to a lesser extent) levels of playful social interaction were markedly reduced compared to controls. These DAT+Sil rats displayed a marked 'gambling-like' profile (i.e. preference for a large/uncertain over a small/sure reward), which disappeared upon doxycycline-induced switch-off onto DAT enhancer, but consistently reappeared with doxycycline removal. MRI-guided 1H-MRS (at 4.7 T) examinations in vivo (under anaesthesia) revealed changes in the bioenergetic metabolites (phosphocreatine and total creatine) for DAT+Sil rats, indicating a functional up-regulation of dorsal striatum (Str) and conversely a down-regulation of ventral striatum (i.e. nucleus accumbens, NAc). A combined profile of (1) enhanced proneness to gambling and (2) strong social withdrawal is thus associated with altered DAT-induced balance within forebrain dopamine systems. In fact, risk of developing a gambling-prone, social-avoidant psychopathology might be associated with (1) dominant semi-automatic strategies and/or habits, developed within Str circuits, and (2) reduced NAc function, with poorer feedback adjustment on decisions by aversive experiences.

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Delay aversion but preference for large and rare rewards in two choice tasks: implications for the measurement of self-control parameters

Cited by 61 publications

References 46 publications

Dopaminergic Modulation of Risk-Based Decision Making

Dopaminergic Modulation of Risk-Based Decision Making

Comparison of probabilistic choice models in humans

Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens

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