Delay-Dependent Response in Weakly Electric Fish under Closed-Loop Pulse Stimulation

Forlim, Caroline Garcia; Pinto, Reynaldo D.; Varona, Pablo; Rodrı́guez, Francisco

doi:10.1371/journal.pone.0141007

Cited by 13 publications

(16 citation statements)

References 40 publications

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“…Beyond dynamical-clamp protocols, other stimulation and detection techniques that can improve their performance by using real-time technology are fMRI (Rana et al, 2016), optogenetics (Krook-Magnuson et al, 2013;Prsa et al, 2017), EEG setups (Arrouët et al, 2005;Sitaram et al, 2016), neuroprosthesess , or any kind of activity-dependent stimulation experiment, such as the ones that use simultaneous electrophysiological and video tracking (Muñiz et al, 2011), acute mechanical stimulation (Muñiz et al, 2008), electric signalling during behavior (Forlim et al, 2015;Lareo et al, 2016) or drug microinjection (Chamorro et al, 2009(Chamorro et al, , 2012.…”

Section: Introductionmentioning

confidence: 99%

RTHybrid: a standardized and open-source real-time software model library for experimental neuroscience

Amaducci

Reyes-Sanchez

Elices

et al. 2018

Preprint

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Closed-loop technologies provide novel ways of online observation, control and bidirectional interaction with the nervous system, which help to study complex non-linear and partially observable neural dynamics. These protocols are often difficult to implement due to the temporal precision required when interacting with biological components, which in many cases can only be achieved using real-time technology. In this paper we introduce RTHybrid (www.github.com/GNB-UAM/RTHybrid), a free and open-source software that includes a neuron and synapse model library to build hybrid circuits with living neurons in a wide variety of experimental contexts. In an effort to encourage the standardization of real-time software technology in neuroscience research, we compared different open-source real-time operating system patches, RTAI, Xenomai 3 and Preempt-RT, according to their performance and usability. RTHybrid has been developed to run over Linux operating systems supporting both Xenomai 3 and Preempt-RT real-time patches, and thus allowing an easy implementation in any laboratory. We report a set of validation tests and latency benchmarks for the construction of hybrid circuits using this library. With this work we want to promote the dissemination of standardized, userfriendly and open-source software tools developed for open-and closed-loop experimental neuroscience.

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Section: Introductionmentioning

confidence: 99%

RTHybrid: a standardized and open-source real-time software model library for experimental neuroscience

Amaducci

Reyes-Sanchez

Elices

et al. 2018

Preprint

Self Cite

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“…We used a phase-locked playback approach inspired by the early works of Heiligenberg and Altes (1978), and more recently Forlim et al (2015). Playback EODws were generated through the sound card as an "electrical echo" on a fixed 25 ms delay relative to the receiver's self-generated EOD.…”

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confidence: 99%

Waveform discrimination in a pair of pulse‐generating electric fishes

Waddell

Caputi

2020

Journal of Fish Biology

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Studies of pulse‐type gymnotiform electric fishes have suggested that electric organ discharge waveforms (EODw) allow individuals to discriminate between conspecific and allospecific signals, but few have approached this experimentally. Here we implement a phase‐locked playback technique for a syntopic species pair, Brachyhypopomus gauderio and Gymnotus omarorum. Both species respond to changes in stimulus waveform with a transitory reduction in the interpulse interval of their self‐generated discharge, providing strong evidence of discrimination. We also document sustained rate changes in response to different EODws, which may suggest recognition of natural waveforms.

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“…The implemented model and its computational efficiency also enables 318 closer-to-natural stimulation to perform more realistic closed-loop experiments with the 319 real system (as pulse mormyrids have been previously used in several closed-loop studies 320 where stimulation is guided by the fish own activity [13,14,20]). In this context, we can 321 expect these experiments to benefit from a more realistic stimulator based in the 322 described model [20].…”

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confidence: 99%

Modeling the variability of the electromotor command system of pulse electric fish

Fernández

Varona

Rodríguez

2020

Preprint

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The electromotor neural system in weakly electric fish is a network responsible for active electroreception and electrolocation. This system controls the timing of pulse generation in the electrical signals used by these fish for extracting information from the environment and communicating with other specimens. Ethological studies related to fish mating, exploratory, submissive or aggressive behaviors have described distinct sequences of pulse intervals (SPIs). Accelerations, scallops, rasps, and cessations are four patterns of SPIs reported in pulse mormyrids, each showing characteristic temporal structures and large variability both in timing and duration. This paper presents a biologically plausible computational model of the electromotor command circuit that reproduces these four SPI patterns as a function of the input to the model while keeping the same internal parameter configuration. The topology of the model is based on a simplified representation of the network as described by morphological and electrophysiological studies. An initial ad hoc tuned configuration (S-T) was build to reproduce all four SPI patterns. Then, starting from S-T, a genetic algorithm (GA) was developed to automatically find the parameters of the model connectivity. Two different configurations obtained from the GA are presented here: one optimized to a set of synthetic examples of SPI patterns based on experimental observations in mormyrids (S-GA), and another configuration adjusted to patterns recorded from freely-behaving Gnathonemus Petersii specimens (R-GA). A robustness analysis to input variability of these model configurations was performed to discard overfitting and assess validity. Results showed that the four SPI patterns are consistently reproduced, both with synthetic (S-GA) data and with signals recorded from behaving animals (R-GA). This new model can be used as a tool to analyze the electromotor command chain during electrogeneration and assess the role of temporal structure in electroreception. Author summaryWeakly electric fish are a convenient system to study information processing in the nervous system. These fish have a remarkable sense of active electroreception, which allows them to generate and detect electrical fields for locating objects and communicating with other specimens in their surroundings. The electrical signal generated by these fish can be easily monitored noninvasively in freely-behaving animals. Activity patterns in this signal have been associated to different fish behaviors, like aggression or mating, for some species of the mormyridae family. In this work we use discharge patterns recorded from specimens of the Gnathonemus Petersii species along 1/20 with synthetic data to develop a model of the electromotor command network. The model network is based on morphological and physiological studies in this type of weakly electric fish. The parameters of this model were tuned using a genetic algorithm to fit both synthetic and recorded activity patterns. This computational model allows to simula...

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Delay-Dependent Response in Weakly Electric Fish under Closed-Loop Pulse Stimulation

Cited by 13 publications

References 40 publications

RTHybrid: a standardized and open-source real-time software model library for experimental neuroscience

RTHybrid: a standardized and open-source real-time software model library for experimental neuroscience

Waveform discrimination in a pair of pulse‐generating electric fishes

Modeling the variability of the electromotor command system of pulse electric fish

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