Delayed axonal pruning in the ant brain: A study of developmental trajectories

Seid, Marc A.

doi:10.1002/dneu.20709

Cited by 33 publications

(33 citation statements)

References 62 publications

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“…Alternatively, an increased neuropil volume may result from greater sensory load. The detection and discrimination of many flower compounds during foraging would induce high activity in the olfactory pathway, thereby triggering the growth of neuronal elements in the lips (Farris et al, 2001;Jones et al, 2009;Seid and Wehner, 2009).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Memory Leads to Synaptic Reorganization in the Mushroom Bodies: A Memory Trace in the Insect Brain?

Hourcade

Muenz²,

Sandoz³

et al. 2010

J. Neurosci.

175

169

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The insect mushroom bodies (MBs) are paired brain centers which, like the mammalian hippocampus, have a prominent function in learning and memory. Despite convergent evidence for their crucial role in the formation and storage of associative memories, little is known about the mechanisms underlying such storage. In mammals and other species, the consolidation of stable memories is accompanied by structural plasticity involving variations in synapse number and/or size. Here, we address the question of whether the formation of olfactory long-term memory (LTM) could be associated with changes in the synaptic architecture of the MB networks. For this, we took advantage of the modular architecture of the honeybee MB neuropil, where synaptic contacts between olfactory input and MB neurons are segregated into discrete units (microglomeruli) which can be easily visualized and counted. We show that the density in microglomeruli increases as a specific olfactory LTM is formed, while the volume of the neuropil remains constant. Such variation is reproducible and is clearly correlated with memory consolidation, as it requires gene transcription. Thus stable structural synaptic rearrangements, including the growth of new synapses, seem to be a common property of insect and mammalian brain networks involved in the storage of stable memory traces.

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Section: Discussionmentioning

confidence: 99%

Long-Term Memory Leads to Synaptic Reorganization in the Mushroom Bodies: A Memory Trace in the Insect Brain?

Hourcade

Muenz²,

Sandoz³

et al. 2010

J. Neurosci.

175

169

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show abstract

“…CaMKII may also be in a good position to mediate structural plasticity related to stable late long-term memory in MB calyx MG as shown by Hourcade et al (2010). It may well be important to mediate changes in the MB calyx volume as most likely induced by massive dendritic outgrowth in the honeybee (Farris et al, 2001) and in the ant (Seid and Wehner, 2009;Stieb et al, 2010).…”

Section: Cellular and Subcellular Localization Of Pcamkiimentioning

confidence: 99%

CaMKII is differentially localized in synaptic regions of kenyon cells within the mushroom bodies of the honeybee brain

Pasch

Muenz

Rößler

2011

J of Comparative Neurology

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Calcium/calmodulin-dependent protein kinase II (CaMKII) has been linked to neuronal plasticity associated with long-term potentiation as well as structural synaptic plasticity. Previous work in adult honeybees has shown that a single CaMKII gene is strongly expressed in the mushroom bodies (MBs), brain centers associated with sensory integration, and learning and memory formation. To study a potential role of CaMKII in synaptic plasticity, the cellular and subcellular distribution of activated (phosphorylated) pCaMKII protein was investigated at various life stages of the honeybee using immunocytochemistry, confocal microscopy, and western blot analyses. Whereas at pupal stages 3-4 most parts of the brain showed high levels of pCaMKII immunoreactivity, the protein was predominantly concentrated in the MBs in the adult brain. The results show that pCaMKII is present in a specific subpopulation of Kenyon cells, the noncompact cells. Within the olfactory (lip) and visual (collar) subregion of the MB calyx neuropil pCaMKII was colocalized with f-actin in postsynaptic compartments of microglomeruli, indicating that it is enriched in Kenyon cell dendritic spines. This suggests a potential role of CaMKII in Kenyon cell dendritic plasticity. Interestingly, pCaMKII protein was absent in two other types of Kenyon cells, the inner compact cells associated with the multimodal basal ring and the outer compact cells. During adult behavioral maturation from nurse bees to foragers, pCaMKII distribution remained essentially similar at the qualitative level, suggesting a potential role in dendritic plasticity of Kenyon cells throughout the entire life span of a worker bee.

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“…The central complex is involved in visual signal processing and locomotion (and its spatial control) and has additional functions in spatial memory and place learning; its origin is linked to the evolution of compound eyes and walking legs [Pfeiffer and Homberg, 2014]. Variation in these macroscopic and cellular aspects of brain organization is predicted to reflect sociobiological and ecological differences within [Giraldo et al, 2013;Groh et al, 2014;Kelber et al, 2010;Kuebler et al, 2010;Seid and Wehner, 2009;Stieb et al, 2010] and among ant species [Kelber et al, 2009;Muscedere et al, 2014;Stieb et al, 2011;Sulger et al, 2014].…”

Section: Introductionmentioning

confidence: 99%

Neuroanatomical and Morphological Trait Clusters in the Ant Genus <b><i>Pheidole:</i></b> Evidence for Modularity and Integration in Brain Structure

2015

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A central question in brain evolution concerns how selection has structured neuromorphological variation to generate adaptive behavior. In social insects, brain structures differ between reproductive and sterile castes, and worker behavioral specializations related to morphology, age, and ecology are associated with intra- and interspecific variation in investment in functionally different brain compartments. Workers in the hyperdiverse ant genus Pheidole are morphologically and behaviorally differentiated into minor and major subcastes that exhibit distinct species-typical patterns of brain compartment size variation. We examined integration and modularity in brain organization and its developmental patterning in three ecotypical Pheidole species by analyzing intra- and interspecific morphological and neuroanatomical covariation. Our results identified two trait clusters, the first involving olfaction and social information processing and the second composed of brain regions regulating nonolfactory sensorimotor functions. Patterns of size covariation between brain compartments within subcastes were consistent with levels of behavioral differentiation between minor and major workers. Globally, brains of mature workers were more heterogeneous than brains of newly eclosed workers, suggesting diversified developmental trajectories underscore species- and subcaste-typical brain organization. Variation in brain structure associated with the striking worker polyphenism in our sample of Pheidole appears to originate from initially differentiated brain templates that further diverge through species- and subcaste-specific processes of maturation and behavioral development.

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Delayed axonal pruning in the ant brain: A study of developmental trajectories

Cited by 33 publications

References 62 publications

Long-Term Memory Leads to Synaptic Reorganization in the Mushroom Bodies: A Memory Trace in the Insect Brain?

Long-Term Memory Leads to Synaptic Reorganization in the Mushroom Bodies: A Memory Trace in the Insect Brain?

CaMKII is differentially localized in synaptic regions of kenyon cells within the mushroom bodies of the honeybee brain

Neuroanatomical and Morphological Trait Clusters in the Ant Genus <b><i>Pheidole:</i></b> Evidence for Modularity and Integration in Brain Structure

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