Delayed Dissolution and Small Molecule Release from Atomic Layer Deposition Coated Electrospun Nanofibers

Vogel, Nancy A.; Williams, Philip S.; Brozena, Alexandra H.; Sen, Dilara; Atanasov, Sarah E.; Parsons, Gregory N.; Khan, Saad A.

doi:10.1002/admi.201500229

Cited by 12 publications

(11 citation statements)

References 60 publications

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“…cumulative dissolution, thus suggesting a total dissolution over several days. Such a dramatic retardation of dissolution by Al 2 O 3 coatings has also been shown by Vogel et al 35 cycle-coated one. Since the dissolution rates scale with the number of cycles, or in other words with the coating thickness, it is likely that water accesses the nanofiber through defects or bulk transport through the ALD coating.…”

Section: Evaluation Of Surface Modified Lactose On Functional Propertsupporting

confidence: 74%

Nanoengineering of Crystal and Amorphous Surfaces of Pharmaceutical Particles for Biomedical Applications

Zhang

Zara

Quayle

et al. 2019

ACS Appl. Bio Mater.

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The morphology, size and surface properties of pharmaceutical particles form an essential role in the therapeutic performance of active pharmaceutical ingredients (APIs) and excipients as constituents in various drug delivery systems and clinical applications. Recent advances in methods for surface modification, however, rely heavily on liquid-phase based modification processes and afford limited control over the thickness and conformality of the coating. Atomic layer deposition (ALD), on the other hand, enables the formation of conformal nanoscale films on complex structures with thickness control on the molecular level, whilst maintaining the substrate particle size and morphology. Moreover, this enables nanoengineering of surfaces of pharmaceutical particles also in the dry state. Successful nano-engineeering of crystal and amorphous surfaces of pharmaceutical particles is demonstrated in this study whereby functional properties, such as dissolution and dispersability, were tailored for drug delivery applications. This expands on our initial work on ALD of alumina on pharmaceutical particles within the lower micro-to higher nano-size ranges to here probe both crystalline and amorphous lactose substrate surfaces (d 50 3.5 and 21 um). In addition, both water and ozone coreactants were evaluated; the latter having not been evaluated previously for pharmaceutical particles.

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Section: Evaluation Of Surface Modified Lactose On Functional Propertsupporting

confidence: 74%

Nanoengineering of Crystal and Amorphous Surfaces of Pharmaceutical Particles for Biomedical Applications

Zhang

Zara

Quayle

et al. 2019

ACS Appl. Bio Mater.

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“…Vogel et al demonstrated that ALD can be utilized to slow the mat degradation in both humid and aqueous conditions, from several minutes to multiple weeks, just by controlling the thickness of the deposited Al 2 O 3 coating on electrospun poly (vinyl alcohol) nanofibers through increased ALD cycles [ 212 ]. Thus, changing the rate at which nanofibers dissolve modulates the release of embedded small molecules (ketoprofen) within the polymer matrix from minutes to weeks while reducing the “burst” effect [ 212 ].…”

Section: Deposition Techniques For Polymeric Thin Films Fabricationmentioning

confidence: 99%

Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review

2021

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The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery, the factors affecting degradation mechanism, testing methods while offering a retrospective on the evolution of the controlled release of biodegradable polymeric coatings. A literature survey on stability and degradation of different polymeric coatings, which were thoroughly evaluated by different techniques, e.g., polymer mass loss measurements, surface, structural and chemical analysis, was completed. Moreover, we analyzed some shortcomings of the degradation behavior of biopolymers in form of coatings and briefly proposed some solving directions to the main existing problems (e.g., improving measuring techniques resolution, elucidation of complete mathematical analysis of the different degradation mechanisms). Deep studies are still necessary on the dynamic changes which occur to biodegradable polymeric coatings which can help to envisage the future performance of synthesized films designed to be used as medical devices with application in drug delivery.

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“…Due to the diffusive and self‐limiting nature of its growth mechanism, this technique allows for sub‐atomic control of layer thickness, in this being superior to the other vapor‐phase methods. Vogel et al reported the treatment of poly(vinyl alcohol) (PVA) electrospun nanofibers loaded with a small molecule drug, ketoprofen, with ALD Al 2 O 3 . The morphology and drug release were monitored as a function of the ALD Al 2 O 3 thickness, ranging from 2 cycles to 200 cycles (Figure ).…”

Section: Strategies For Drug Encapsulation and Controlled Deliverymentioning

confidence: 98%

“…Next to polymer encapsulation, very recently vapor‐phase deposited metal‐oxides have been adopted as drug release barriers, either directly deposited on the drug crystals or on drug loaded polymers …”

Section: Strategies For Drug Encapsulation and Controlled Deliverymentioning

confidence: 99%

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Strategies for Drug Encapsulation and Controlled Delivery Based on Vapor‐Phase Deposited Thin Films

2017

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Vapor-phase deposition methods allow the synthesis and engineering of organic and inorganic thin films, with high control on the chemical composition, physical properties, and conformality. In this review, the recent applications of vapor-phase deposition methods such as initiated chemical vapor deposition (iCVD), plasma enhanced chemical vapor deposition (PE-CVD), and atomic layer deposition (ALD), for the encapsulation of active pharmaceutical drugs are reported. The strategies and emergent routes for the application of vapor-deposited thin films on the drug controlled release and for the engineering of advanced release nanostructured devices are presented.

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Delayed Dissolution and Small Molecule Release from Atomic Layer Deposition Coated Electrospun Nanofibers

Abstract: nanofi ber coating technique shows great potential as a method to tune shelflife, mat degradation, and small molecule release from highly water-soluble polymers, hitherto unexplored, in a wide range of fi elds, including biomedical, agricultural, and packaging.

Cited by 12 publications

References 60 publications

Nanoengineering of Crystal and Amorphous Surfaces of Pharmaceutical Particles for Biomedical Applications

Nanoengineering of Crystal and Amorphous Surfaces of Pharmaceutical Particles for Biomedical Applications

Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review

Strategies for Drug Encapsulation and Controlled Delivery Based on Vapor‐Phase Deposited Thin Films

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