Delayed Eating Schedule Raises Mean Glucose Levels in Young Adult Males: a Randomized Controlled Cross-Over Trial

Hatamoto, Yoichi; Tanoue, Yukiya; Yoshimura, Eiichi; Matsumoto, Mai; Hayashi, Takanori; Ogata, Hiroyasu; Tanaka, Shigeho; Tanaka, Hiroaki; Higaki, Yasuki

doi:10.1016/j.tjnut.2022.12.024

Cited by 3 publications

(5 citation statements)

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“…A meal frequency of less than three were 3.3 times more likely to have poor glycemic control as compared to their counterparts having a meal frequency of three and more than two snacks. The findings of this study are consistent with research carried out in Japan, which stated that those with low meal frequency increases the mean 24 h interstitial glucose concentration among young diabetic population [ 37 ]; this finding also supported by the study done in Germany [ 38 ] and USA [ 39 , 40 ]. The frequency of diet among T1DM may differ from that of healthy individuals due to disease-related factors that may affect the course of diabetes; waiting too long between meals and/or eating one big meal can rise blood sugar level [ 37 ]; furthermore, skiping meal frequently can lower metabolism, making it actually harder to manage blood glucose [ 41 ].…”

Section: Discussionsupporting

confidence: 92%

“…The findings of this study are consistent with research carried out in Japan, which stated that those with low meal frequency increases the mean 24 h interstitial glucose concentration among young diabetic population [ 37 ]; this finding also supported by the study done in Germany [ 38 ] and USA [ 39 , 40 ]. The frequency of diet among T1DM may differ from that of healthy individuals due to disease-related factors that may affect the course of diabetes; waiting too long between meals and/or eating one big meal can rise blood sugar level [ 37 ]; furthermore, skiping meal frequently can lower metabolism, making it actually harder to manage blood glucose [ 41 ]. This insight will have an important implication in determining mealing approach to individuals with diabetes; recent evidence suggests that both meal frequency and daily energy distribution can influence glycaemic control [ 41 , 42 ].…”

Section: Discussionsupporting

confidence: 92%

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Poor glycemic control and its associated factors among children with type 1 diabetes mellitus in Harar, eastern Ethiopia: A cross-sectional study

Habteyohans,

Hailu,

Meseret

et al. 2023

BMC Endocr Disord

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Background Poor glycemic control increases the risk of acute metabolic derangements and long-term consequences, which are the main causes of morbidity and mortality. Maintaining adequate glycemic control is challenging for children with diabetes, particularly in resource-limited settings. There is a paucity of data on the magnitude of poor glycemic control and its predisposing factors in Ethiopian particularly in this study setting. Hence, we aimed to assess the magnitude of poor glycemic control and its associated factors among children and adolescents with type 1 diabetic mellitus in Jugol and Hiwot Fana Compressive Specialized University Hospitals in Harar, eastern Ethiopia. Methods A facility-based cross-sectional study was conducted among 231 children and adolescents with type 1 diabetes mellitus in Jugol and Hiwot Fana Compressive Specialized University Hospitals. Participants were included consecutively in the follow-up clinic from November 15, 2022 to January 15, 2023. Data were collected through an interviewer-administered structured questionnaire and a review of medical records. A binary logistic regression model with an adjusted odds ratio (aOR) and a 95% confidence interval (CI) was used to identify the factors associated with poor glycemic control. Statistical significance was set at p < 0.05. Result A total of 231 children and adolescents with type 1 diabetes mellitus were included. The magnitude of poor glycemic control was 166 (71.9%) with 95% CI 66.0–77.7%). In multivariable analysis, the age of the child (aOR = 0.19, 95% CI: 0.05–0.83), education of the caregiver (aOR = 4.13;95% CI: 1.82–9.46), meal frequency less than three (aOR = 3.28; 95% CI: 1.25–8.62), and consumption of forbidden foods (aOR = 3.17; 95% CI: 1.21–8.29) were factors significantly associated with poor glycemic control. Conclusion Two-thirds of participants had poor glycemic control. There was a statistically significant association between the age of the child, education of the caregiver, meal frequency, and forbidden foods with poor glycemic control. To improve glycemic control, diabetes education on meal use and selection should be conducted during follow-up along with parent education.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Poor glycemic control and its associated factors among children with type 1 diabetes mellitus in Harar, eastern Ethiopia: A cross-sectional study

Habteyohans,

Hailu,

Meseret

et al. 2023

BMC Endocr Disord

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“…In addition, a later first meal (after 9 a.m.) is associated with a higher risk of type 2 diabetes 130 . In controlled laboratory conditions, a delayed eating schedule increased mean glucose levels as measured with continuous glucose monitoring 131 . In a recent 2021 crossover randomized‐controlled trial in healthy humans, the authors investigated the metabolic effects of 8 weeks of delayed eating (12:00–23:00) versus 8 weeks of early eating (08:00–19:00).…”

Section: Circadian Desynchrony Disturbs Glucose Metabolismmentioning

confidence: 99%

Circadian desynchrony and glucose metabolism

Speksnijder,

Bisschop,

Siegelaar

et al. 2024

Journal of Pineal Research

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The circadian timing system controls glucose metabolism in a time‐of‐day dependent manner. In mammals, the circadian timing system consists of the main central clock in the bilateral suprachiasmatic nucleus (SCN) of the anterior hypothalamus and subordinate clocks in peripheral tissues. The oscillations produced by these different clocks with a period of approximately 24‐h are generated by the transcriptional‐translational feedback loops of a set of core clock genes. Glucose homeostasis is one of the daily rhythms controlled by this circadian timing system. The central pacemaker in the SCN controls glucose homeostasis through its neural projections to hypothalamic hubs that are in control of feeding behavior and energy metabolism. Using hormones such as adrenal glucocorticoids and melatonin and the autonomic nervous system, the SCN modulates critical processes such as glucose production and insulin sensitivity. Peripheral clocks in tissues, such as the liver, muscle, and adipose tissue serve to enhance and sustain these SCN signals. In the optimal situation all these clocks are synchronized and aligned with behavior and the environmental light/dark cycle. A negative impact on glucose metabolism becomes apparent when the internal timing system becomes disturbed, also known as circadian desynchrony or circadian misalignment. Circadian desynchrony may occur at several levels, as the mistiming of light exposure or sleep will especially affect the central clock, whereas mistiming of food intake or physical activity will especially involve the peripheral clocks. In this review, we will summarize the literature investigating the impact of circadian desynchrony on glucose metabolism and how it may result in the development of insulin resistance. In addition, we will discuss potential strategies aimed at reinstating circadian synchrony to improve insulin sensitivity and contribute to the prevention of type 2 diabetes.

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“…Eating dinner late reportedly promotes insulin resistance and weight gain [ 116 ]. In an experimental study on young Japanese adults, a late eating schedule (12:00 PM, 5:00 PM, and 11:00 PM) increased the mean glucose concentration estimated using a continuous glucose monitor [ 117 ]. Kwak et al [ 118 ] showed that individuals fasting nightly for greater than 12 hours or eating the last meal before 9:00 PM had lower odds of developing T2DM.…”

Section: Disruptive Circadian Rhythms and T2dmmentioning

confidence: 99%

“…Fast-feeding rhythms, consisting of the timing, frequency, and regularity of dietary intake, are among the main components of circadian rhythms. Various studies have demonstrated the impact of diet timing, the so-called chrononutrition, on glucose metabolism [116][117][118][119][120].…”

Section: Disruption In Fasting-feeding Rhythmsmentioning

confidence: 99%

Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes

Lee,

Jung,

Park

et al. 2024

Diabetes Metab J

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Novel strategies are required to reduce the risk of developing diabetes and/or clinical outcomes and complications of diabetes. In this regard, the role of the circadian system may be a potential candidate for the prevention of diabetes. We reviewed evidence from animal, clinical, and epidemiological studies linking the circadian system to various aspects of the pathophysiology and clinical outcomes of diabetes. The circadian clock governs genetic, metabolic, hormonal, and behavioral signals in anticipation of cyclic 24-hour events through interactions between a “central clock” in the suprachiasmatic nucleus and “peripheral clocks” in the whole body. Currently, circadian rhythmicity in humans can be subjectively or objectively assessed by measuring melatonin and glucocorticoid levels, core body temperature, peripheral blood, oral mucosa, hair follicles, rest-activity cycles, sleep diaries, and circadian chronotypes. In this review, we summarized various circadian misalignments, such as altered light-dark, sleep-wake, rest-activity, fasting-feeding, shift work, evening chronotype, and social jetlag, as well as mutations in clock genes that could contribute to the development of diabetes and poor glycemic status in patients with diabetes. Targeting critical components of the circadian system could deliver potential candidates for the treatment and prevention of type 2 diabetes mellitus in the future.

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Delayed Eating Schedule Raises Mean Glucose Levels in Young Adult Males: a Randomized Controlled Cross-Over Trial

Cited by 3 publications

References 44 publications

Poor glycemic control and its associated factors among children with type 1 diabetes mellitus in Harar, eastern Ethiopia: A cross-sectional study

Poor glycemic control and its associated factors among children with type 1 diabetes mellitus in Harar, eastern Ethiopia: A cross-sectional study

Circadian desynchrony and glucose metabolism

Attention to Innate Circadian Rhythm and the Impact of Its Disruption on Diabetes

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