Delayed hypersensitivity reaction to paracetamol (acetaminophen)

Abstract

We are reporting three patients who experienced delayed cutaneous reactions after treatment with paracetamol (acetaminophen). These reactions were confirmed in controlled challenge tests. Patch tests with paracetamol were positive in all patients. A biopsy performed of the case 1 patch test confirmed that the lesion was compatible with delayed hypersensitivity reaction-type allergic contact dermatitis.

Acetaminophen‐Induced Toxic Epidermal Necrolysis in a Child

“…Therefore it is often unclear if acetaminophen is the causative agent. Hypersensitivity reactions to acetaminophen are rare, but there are a few reports in the literature of patients with skin manifestations (9,12,13). Recently there was a report of TEN elicited by acetaminophen in a 7‐year‐old girl (14).…”